Class information for:
Level 1: IRAK 4//TIR DOMAIN//IRAK

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13288 848 46.1 95%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
449 3       FAMILIAL MEDITERRANEAN FEVER//TOLL LIKE RECEPTORS//INFLAMMASOME 25887
543 2             TOLL LIKE RECEPTORS//INNATE IMMUNITY//CPG ODN 14712
13288 1                   IRAK 4//TIR DOMAIN//IRAK 848

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IRAK 4 authKW 832219 4% 66% 35
2 TIR DOMAIN authKW 576092 3% 57% 28
3 IRAK authKW 441257 3% 51% 24
4 PELLINO authKW 324065 1% 100% 9
5 INNATE IMMUN INFLAMMAT address 304252 2% 65% 13
6 TOLLIP authKW 297335 2% 52% 16
7 IRAK1 authKW 250597 3% 30% 23
8 MYD88 authKW 232871 7% 11% 59
9 TIRAP authKW 217315 2% 46% 13
10 MYDDOSOME authKW 180036 1% 100% 5

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Immunology 5667 40% 0% 335
2 Biochemistry & Molecular Biology 1789 40% 0% 336
3 Cell Biology 1193 21% 0% 174
4 Biophysics 236 7% 0% 60
5 Medicine, Research & Experimental 98 5% 0% 44
6 Microbiology 50 5% 0% 40
7 Hematology 50 3% 0% 27
8 Infectious Diseases 44 3% 0% 25
9 Chemistry, Medicinal 40 3% 0% 24
10 Fisheries 37 2% 0% 14

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INNATE IMMUN INFLAMMAT 304252 2% 65% 13
2 MOL PHARMAKOL OE 5320 72014 0% 100% 2
3 PROT SIGNALING DOMAINS 68216 1% 32% 6
4 METAB CARE GASTROINTESTINAL SURG 64811 0% 60% 3
5 FRENCH CHINESE GENET LIFE SCI 40504 0% 38% 3
6 ABT PHARMAZEUT CHEM 2 36007 0% 100% 1
7 AFFILIATED PATHOL 36007 0% 100% 1
8 BIOCOMM SQUARED 36007 0% 100% 1
9 BIOLUPUS NETWORK 36007 0% 100% 1
10 BIOMOL MAGNET ONANCE IL 36007 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NATURE IMMUNOLOGY 4692 2% 1% 17
2 JOURNAL OF ENDOTOXIN RESEARCH 4167 1% 1% 8
3 JOURNAL OF IMMUNOLOGY 2775 8% 0% 65
4 JOURNAL OF BIOLOGICAL CHEMISTRY 2229 12% 0% 99
5 JOURNAL OF INNATE IMMUNITY 1909 1% 1% 5
6 MOLECULAR IMMUNOLOGY 1630 2% 0% 18
7 TRENDS IN IMMUNOLOGY 1355 1% 1% 7
8 DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY 1202 1% 0% 11
9 FISH & SHELLFISH IMMUNOLOGY 1155 1% 0% 12
10 INNATE IMMUNITY 1120 0% 1% 4

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 IRAK 4 832219 4% 66% 35 Search IRAK+4 Search IRAK+4
2 TIR DOMAIN 576092 3% 57% 28 Search TIR+DOMAIN Search TIR+DOMAIN
3 IRAK 441257 3% 51% 24 Search IRAK Search IRAK
4 PELLINO 324065 1% 100% 9 Search PELLINO Search PELLINO
5 TOLLIP 297335 2% 52% 16 Search TOLLIP Search TOLLIP
6 IRAK1 250597 3% 30% 23 Search IRAK1 Search IRAK1
7 MYD88 232871 7% 11% 59 Search MYD88 Search MYD88
8 TIRAP 217315 2% 46% 13 Search TIRAP Search TIRAP
9 MYDDOSOME 180036 1% 100% 5 Search MYDDOSOME Search MYDDOSOME
10 PELLINO 1 176431 1% 70% 7 Search PELLINO+1 Search PELLINO+1

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FLANNERY, S , BOWIE, AG , (2010) THE INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES: CRITICAL REGULATORS OF INNATE IMMUNE SIGNALLING.BIOCHEMICAL PHARMACOLOGY. VOL. 80. ISSUE 12. P. 1981-1991 58 62% 93
2 PATRA, MC , CHOI, S , (2016) RECENT PROGRESS IN THE MOLECULAR RECOGNITION AND THERAPEUTIC IMPORTANCE OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4.MOLECULES. VOL. 21. ISSUE 11. P. - 49 74% 0
3 VE, T , GAY, NJ , MANSELL, A , KOBE, B , KELLIE, S , (2012) ADAPTORS IN TOLL-LIKE RECEPTOR SIGNALING AND THEIR POTENTIAL AS THERAPEUTIC TARGETS.CURRENT DRUG TARGETS. VOL. 13. ISSUE 11. P. 1360-1374 81 44% 15
4 DELLA MINA, E , BORGHESI, A , ZHOU, H , BOUGARN, S , BOUGHORBEL, S , ISRAEL, L , MELONI, I , CHRABIEH, M , LING, Y , ITAN, Y , ET AL (2017) INHERITED HUMAN IRAK-1 DEFICIENCY SELECTIVELY IMPAIRS TLR SIGNALING IN FIBROBLASTS.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 114. ISSUE 4. P. E514 -E523 57 57% 0
5 GOTTIPATI, S , RAO, NL , FUNG-LEUNG, WP , (2008) IRAK1: A CRITICAL SIGNALING MEDIATOR OF INNATE IMMUNITY.CELLULAR SIGNALLING. VOL. 20. ISSUE 2. P. 269-276 46 65% 116
6 SNYDER, GA , SUNDBERG, EJ , (2014) MOLECULAR INTERACTIONS IN INTERLEUKIN AND TOLL-LIKE RECEPTOR SIGNALING PATHWAYS.CURRENT PHARMACEUTICAL DESIGN. VOL. 20. ISSUE 8. P. 1244-1258 76 40% 0
7 VYNCKE, L , BOVIJN, C , PAUWELS, E , VAN ACKER, T , RUYSSINCK, E , BURG, E , TAVERNIER, J , PEELMAN, F , (2016) RECONSTRUCTING THE TIR SIDE OF THE MYDDOSOME: A PARADIGM FOR TIR-TIR INTERACTIONS.STRUCTURE. VOL. 24. ISSUE 3. P. 437 -447 38 70% 1
8 SNYDER, GA , CIRL, C , JIANG, JS , CHEN, K , WALDHUBER, A , SMITH, P , ROMMLER, F , SNYDER, N , FRESQUEZ, T , DURR, S , ET AL (2013) MOLECULAR MECHANISMS FOR THE SUBVERSION OF MYD88 SIGNALING BY TCPC FROM VIRULENT UROPATHOGENIC ESCHERICHIA COLI.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. VOL. 110. ISSUE 17. P. 6985 -6990 38 68% 27
9 CHAUDHARY, D , ROBINSON, S , ROMERO, DL , (2015) RECENT ADVANCES IN THE DISCOVERY OF SMALL MOLECULE INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE 4 (IRAK4) AS A THERAPEUTIC TARGET FOR INFLAMMATION AND ONCOLOGY DISORDERS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 58. ISSUE 1. P. 96 -110 39 57% 17
10 KAWAGOE, T , SATO, S , MATSUSHITA, K , KATO, H , MATSUI, K , KUMAGAI, Y , SAITOH, T , KAWAI, T , TAKEUCHI, O , AKIRA, S , (2008) SEQUENTIAL CONTROL OF TOLL-LIKE RECEPTOR-DEPENDENT RESPONSES BY IRAK1 AND IRAK2.NATURE IMMUNOLOGY. VOL. 9. ISSUE 6. P. 684-691 34 71% 173

Classes with closest relation at Level 1


Rank Class id link
1 4753 TOLL LIKE RECEPTORS//TLR7//TOLL LIKE RECEPTOR 7
2 16857 ENDOTOXIN TOLERANCE//LPS TOLERANCE//IRAK M
3 14603 TOLL LIKE RECEPTORS//TLR6//TOLL LIKE RECEPTOR 4
4 24258 TAK1//TAB1//TGF BETA ACTIVATED KINASE 1
5 17952 TRAF4//TRAF6//TRAF2
6 2033 RIG I//MAVS//MDA5
7 2866 CD14//MD 2//LIPOPOLYSACCHARIDE BINDING PROTEIN
8 23666 IL 37//INTERLEUKIN 37//IL 36
9 36251 CELL RECOGNIT PONSE//I KAPPA B ZETA//I KAPPA B XI
10 12109 TOLL LIKE RECEPTORS//TOLL LIKE RECEPTOR 4//TOLL LIKE RECEPTOR 2

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