Class information for:
Level 1: OPIOID INDUCED CONSTIPATION//METHYLNALTREXONE//OPIOID INDUCED BOWEL DYSFUNCTION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
11538 975 32.4 60%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
337 3       IRRITABLE BOWEL SYNDROME//CONSTIPATION//ENTERIC NERVOUS SYSTEM 37464
111 2             IRRITABLE BOWEL SYNDROME//NEUROGASTROENTEROLOGY AND MOTILITY//FUNCTIONAL DYSPEPSIA 25141
11538 1                   OPIOID INDUCED CONSTIPATION//METHYLNALTREXONE//OPIOID INDUCED BOWEL DYSFUNCTION 975

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 OPIOID INDUCED CONSTIPATION authKW 1609982 6% 92% 56
2 METHYLNALTREXONE authKW 1313385 6% 71% 59
3 OPIOID INDUCED BOWEL DYSFUNCTION authKW 971768 3% 97% 32
4 NALOXEGOL authKW 688970 2% 100% 22
5 CONSTIPATION authKW 333651 17% 6% 165
6 ALVIMOPAN authKW 255728 2% 39% 21
7 OXYCODONE NALOXONE authKW 184208 1% 59% 10
8 LAXATIVES authKW 147634 4% 11% 42
9 PERIPHERAL OPIOID ANTAGONIST authKW 125267 0% 100% 4
10 PERIPHERALLY RESTRICTED OPIOID RECEPTOR ANTAGONISTS authKW 125267 0% 100% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Pharmacology & Pharmacy 5427 44% 0% 428
2 Gastroenterology & Hepatology 2249 15% 0% 147
3 Health Care Sciences & Services 1674 9% 0% 90
4 Anesthesiology 742 6% 0% 54
5 Medicine, General & Internal 511 12% 0% 117
6 Medicine, Research & Experimental 335 8% 0% 78
7 Clinical Neurology 320 9% 0% 91
8 Physiology 204 6% 0% 58
9 Neurosciences 100 9% 0% 83
10 Primary Health Care 67 1% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FUNDESALUD 62634 0% 100% 2
2 REG OBSERV PALLIAT CARE EXTREMADURA 62634 0% 100% 2
3 PRACT PHARM PHARMACEUT CARE 41754 0% 67% 2
4 CHAIR PALLIAT MED 41462 1% 19% 7
5 PALLIAT CARE SUPPORT TEAM 38538 0% 31% 4
6 CLIN PALLIAT MED 35228 0% 38% 3
7 ADV PAIN 31317 0% 100% 1
8 AMER PAIN MED 31317 0% 100% 1
9 AMER PAIN MED FDN 31317 0% 100% 1
10 ANAESTHESIOL INTENS CARE PAIN THER Y PALL 31317 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF PAIN AND SYMPTOM MANAGEMENT 10155 3% 1% 33
2 EUROPEAN JOURNAL OF PHARMACOLOGY 3948 6% 0% 60
3 LIFE SCIENCES 3229 5% 0% 46
4 JOURNAL OF PALLIATIVE MEDICINE 2762 1% 1% 12
5 NEUROGASTROENTEROLOGY AND MOTILITY 2708 2% 1% 15
6 JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2446 4% 0% 41
7 PHARMACOLOGY 2418 2% 0% 16
8 THERAPEUTIC ADVANCES IN GASTROENTEROLOGY 2367 0% 2% 4
9 ARCHIVES INTERNATIONALES DE PHARMACODYNAMIE ET DE THERAPIE 1977 1% 1% 12
10 SCHMERZ 1800 1% 1% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 OPIOID INDUCED CONSTIPATION 1609982 6% 92% 56 Search OPIOID+INDUCED+CONSTIPATION Search OPIOID+INDUCED+CONSTIPATION
2 METHYLNALTREXONE 1313385 6% 71% 59 Search METHYLNALTREXONE Search METHYLNALTREXONE
3 OPIOID INDUCED BOWEL DYSFUNCTION 971768 3% 97% 32 Search OPIOID+INDUCED+BOWEL+DYSFUNCTION Search OPIOID+INDUCED+BOWEL+DYSFUNCTION
4 NALOXEGOL 688970 2% 100% 22 Search NALOXEGOL Search NALOXEGOL
5 CONSTIPATION 333651 17% 6% 165 Search CONSTIPATION Search CONSTIPATION
6 ALVIMOPAN 255728 2% 39% 21 Search ALVIMOPAN Search ALVIMOPAN
7 OXYCODONE NALOXONE 184208 1% 59% 10 Search OXYCODONE+NALOXONE Search OXYCODONE+NALOXONE
8 LAXATIVES 147634 4% 11% 42 Search LAXATIVES Search LAXATIVES
9 PERIPHERAL OPIOID ANTAGONIST 125267 0% 100% 4 Search PERIPHERAL+OPIOID+ANTAGONIST Search PERIPHERAL+OPIOID+ANTAGONIST
10 PERIPHERALLY RESTRICTED OPIOID RECEPTOR ANTAGONISTS 125267 0% 100% 4 Search PERIPHERALLY+RESTRICTED+OPIOID+RECEPTOR+ANTAGONISTS Search PERIPHERALLY+RESTRICTED+OPIOID+RECEPTOR+ANTAGONISTS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HOLZER, P , (2012) NON-ANALGESIC EFFECTS OF OPIOIDS: MANAGEMENT OF OPIOID-INDUCED CONSTIPATION BY PERIPHERAL OPIOID RECEPTOR ANTAGONISTS: PREVENTION OR WITHDRAWAL?.CURRENT PHARMACEUTICAL DESIGN. VOL. 18. ISSUE 37. P. 6010 -6020 71 76% 15
2 LEPPERT, W , (2015) EMERGING THERAPIES FOR PATIENTS WITH SYMPTOMS OF OPIOID-INDUCED BOWEL DYSFUNCTION.DRUG DESIGN DEVELOPMENT AND THERAPY. VOL. 9. ISSUE . P. 2215 -2231 67 70% 8
3 GAERTNER, J , SIEMENS, W , CAMILLERI, M , DAVIES, A , DROSSMAN, DA , WEBSTER, LR , BECKER, G , (2015) DEFINITIONS AND OUTCOME MEASURES OF CLINICAL TRIALS REGARDING OPIOID-INDUCED CONSTIPATION A SYSTEMATIC REVIEW.JOURNAL OF CLINICAL GASTROENTEROLOGY. VOL. 49. ISSUE 1. P. 9 -16 41 84% 13
4 BECKER, G , BADER, S , DURK, T , (2013) METHYLNALTREXONE FOR THE TREATMENT OF OPIOID-INDUCED CONSTIPATION.EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY. VOL. 7. ISSUE 1. P. 13 -26 59 64% 11
5 HOLZER, P , (2009) OPIOID RECEPTORS IN THE GASTROINTESTINAL TRACT.REGULATORY PEPTIDES. VOL. 155. ISSUE 1-3. P. 11 -17 45 74% 108
6 PERGOLIZZI, JV , RAFFA, RB , PAPPAGALLO, M , FLEISCHER, C , PERGOLIZZI, J , ZAMPOGNA, G , DUVAL, E , HISHMEH, J , LEQUANG, JA , TAYLOR, R , (2017) PERIPHERALLY ACTING MU-OPIOID RECEPTOR ANTAGONISTS AS TREATMENT OPTIONS FOR CONSTIPATION IN NONCANCER PAIN PATIENTS ON CHRONIC OPIOID THERAPY.PATIENT PREFERENCE AND ADHERENCE. VOL. 11. ISSUE . P. - 40 82% 0
7 SIEMENS, W , GAERTNER, J , BECKER, G , (2015) ADVANCES IN PHARMACOTHERAPY FOR OPIOID-INDUCED CONSTIPATION - A SYSTEMATIC REVIEW.EXPERT OPINION ON PHARMACOTHERAPY. VOL. 16. ISSUE 4. P. 515 -532 34 87% 6
8 POULSEN, JL , BROCK, C , OLESEN, AE , NILSSON, M , DREWES, AM , (2015) EVOLVING PARADIGMS IN THE TREATMENT OF OPIOID-INDUCED BOWEL DYSFUNCTION.THERAPEUTIC ADVANCES IN GASTROENTEROLOGY. VOL. 8. ISSUE 6. P. 360 -372 50 59% 5
9 ARGOFF, CE , BRENNAN, MJ , CAMILLERI, M , DAVIES, A , FUDIN, J , GALLUZZI, KE , GUDIN, J , LEMBO, A , STANOS, SP , WEBSTER, LR , (2015) CONSENSUS RECOMMENDATIONS ON INITIATING PRESCRIPTION THERAPIES FOR OPIOID-INDUCED CONSTIPATION.PAIN MEDICINE. VOL. 16. ISSUE 12. P. 2324 -2337 38 75% 5
10 LEPPERT, W , WORON, J , (2016) THE ROLE OF NALOXEGOL IN THE MANAGEMENT OF OPIOID-INDUCED BOWEL DYSFUNCTION.THERAPEUTIC ADVANCES IN GASTROENTEROLOGY. VOL. 9. ISSUE 5. P. 736 -746 30 97% 0

Classes with closest relation at Level 1


Rank Class id link
1 31784 TRIMEBUTINE//CAS 39133 31 8//CAS 34140 59 5
2 28259 METHYLFLAVONOLAMINE//MUSCARINIC AUTOINHIBITION//CERVICAL SMOOTH MUSCLE
3 2457 CONSTIPATION//SLOW TRANSIT CONSTIPATION//CHRONIC CONSTIPATION
4 5760 INTESTINAL SECRETION//SORBIN//E COLI STA
5 3821 DYNORPHIN//DYNORPHIN A//KAPPA OPIOID RECEPTOR
6 4608 POSTOPERATIVE ILEUS//FAST TRACK SURGERY//ENHANCED RECOVERY AFTER SURGERY
7 37593 LOPERAMIDE//LOPERAMIDE HYDROCHLORIDE//DESMETHYLLOPERAMIDE
8 1629 ENDOMORPHIN//DELTA OPIOID RECEPTOR//ENDOMORPHIN 2
9 20188 GLUCAGON AND INSULIN//OPIUM SMOKING//OPIOID MU RECEPTORS
10 15086 RX 77368//THYROTROPIN RELEASING HORMONE//VAGUS

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