Class information for:
Level 1: CRTH2//PROSTAGLANDIN D 2//MOL BEHAV BIOL

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
10896 1027 36.1 78%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
275 3       NSAIDS//CYCLOOXYGENASE//CYCLOOXYGENASE 2 43399
1311 2             PROSTAGLANDIN D 2//CRTH2//MOL BEHAV BIOL 8520
10896 1                   CRTH2//PROSTAGLANDIN D 2//MOL BEHAV BIOL 1027

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CRTH2 authKW 1756114 8% 76% 78
2 PROSTAGLANDIN D 2 authKW 1709080 14% 39% 148
3 MOL BEHAV BIOL address 1560164 11% 46% 115
4 PROSTAGLANDIN D SYNTHASE authKW 656451 4% 60% 37
5 PGD2 authKW 635221 5% 43% 50
6 DP RECEPTOR authKW 611603 2% 86% 24
7 LIPOCALIN TYPE PROSTAGLANDIN D SYNTHASE authKW 502197 2% 68% 25
8 BETA TRACE authKW 412794 2% 73% 19
9 CRTH2 ANTAGONIST authKW 390550 2% 77% 17
10 DP2 authKW 295555 1% 76% 13

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Allergy 1409 6% 0% 58
2 Biochemistry & Molecular Biology 1037 29% 0% 299
3 Chemistry, Medicinal 1013 10% 0% 102
4 Pharmacology & Pharmacy 831 19% 0% 191
5 Immunology 609 13% 0% 136
6 Neurosciences 316 13% 0% 129
7 Cell Biology 233 10% 0% 99
8 Endocrinology & Metabolism 173 6% 0% 64
9 Biophysics 156 6% 0% 57
10 Respiratory System 146 4% 0% 38

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL BEHAV BIOL 1560164 11% 46% 115
2 HUMAN GENE SCI 141042 2% 22% 22
3 ADV MED DEV 122306 1% 34% 12
4 OSAKA BIOSCI 85687 1% 41% 7
5 ANIM RADIOL 59454 1% 33% 6
6 MENTAL HLTH ENVIRONM EFFECTS 47565 0% 40% 4
7 ABENO KU MED 29731 0% 100% 1
8 ANTIBACT IMMUNOL CANC 29731 0% 100% 1
9 BIOL BEHAV MOL 29731 0% 100% 1
10 BIOQUIM CLININFIBIOC PROT 29731 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PROSTAGLANDINS & OTHER LIPID MEDIATORS 13811 3% 2% 29
2 ADVANCES IN PROSTAGLANDIN THROMBOXANE AND LEUKOTRIENE RESEARCH 4521 1% 1% 11
3 PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS 3783 2% 1% 20
4 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2123 4% 0% 43
5 JOURNAL OF LIPID MEDIATORS 1735 0% 1% 4
6 PROSTAGLANDINS 1623 1% 1% 9
7 EXPERT OPINION ON THERAPEUTIC PATENTS 1066 1% 0% 9
8 JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 984 2% 0% 19
9 JOURNAL OF LIPID MEDIATORS AND CELL SIGNALLING 960 0% 1% 3
10 BRITISH JOURNAL OF PHARMACOLOGY 776 2% 0% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 CRTH2 1756114 8% 76% 78 Search CRTH2 Search CRTH2
2 PROSTAGLANDIN D 2 1709080 14% 39% 148 Search PROSTAGLANDIN+D+2 Search PROSTAGLANDIN+D+2
3 PROSTAGLANDIN D SYNTHASE 656451 4% 60% 37 Search PROSTAGLANDIN+D+SYNTHASE Search PROSTAGLANDIN+D+SYNTHASE
4 PGD2 635221 5% 43% 50 Search PGD2 Search PGD2
5 DP RECEPTOR 611603 2% 86% 24 Search DP+RECEPTOR Search DP+RECEPTOR
6 LIPOCALIN TYPE PROSTAGLANDIN D SYNTHASE 502197 2% 68% 25 Search LIPOCALIN+TYPE+PROSTAGLANDIN+D+SYNTHASE Search LIPOCALIN+TYPE+PROSTAGLANDIN+D+SYNTHASE
7 BETA TRACE 412794 2% 73% 19 Search BETA+TRACE Search BETA+TRACE
8 CRTH2 ANTAGONIST 390550 2% 77% 17 Search CRTH2+ANTAGONIST Search CRTH2+ANTAGONIST
9 DP2 295555 1% 76% 13 Search DP2 Search DP2
10 L PGDS 228378 1% 59% 13 Search L+PGDS Search L+PGDS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 SCHULIGOI, R , STURM, E , LUSCHNIG, P , KONYA, V , PHILIPOSE, S , SEDEJ, M , WALDHOER, M , PESKAR, BA , HEINEMANN, A , (2010) CRTH2 AND D-TYPE PROSTANOID RECEPTOR ANTAGONISTS AS NOVEL THERAPEUTIC AGENTS FOR INFLAMMATORY DISEASES.PHARMACOLOGY. VOL. 85. ISSUE 6. P. 372-382 88 63% 53
2 SANTINI, G , MORES, N , MALERBA, M , MONDINO, C , MACIS, G , MONTUSCHI, P , (2016) INVESTIGATIONAL PROSTAGLANDIN D-2 RECEPTOR ANTAGONISTS FOR AIRWAY INFLAMMATION.EXPERT OPINION ON INVESTIGATIONAL DRUGS. VOL. 25. ISSUE 6. P. 639 -652 55 79% 2
3 ULVEN, T , KOSTENIS, E , (2010) NOVEL CRTH2 ANTAGONISTS: A REVIEW OF PATENTS FROM 2006 TO 2009.EXPERT OPINION ON THERAPEUTIC PATENTS. VOL. 20. ISSUE 11. P. 1505-1530 53 93% 34
4 PETTIPHER, R , HANSEL, TT , ARMER, R , (2007) ANTAGONISM OF THE PROSTAGLANDIN D-2 RECEPTORS DP1 AND CRTH2 AS AN APPROACH TO TREAT ALLERGIC DISEASES.NATURE REVIEWS DRUG DISCOVERY. VOL. 6. ISSUE 4. P. 313 -325 65 65% 149
5 PETTIPHER, R , WHITTAKER, M , (2012) UPDATE ON THE DEVELOPMENT OF ANTAGONISTS OF CHEMOATTRACTANT RECEPTOR-HOMOLOGOUS MOLECULE EXPRESSED ON TH2 CELLS (CRTH2). FROM LEAD OPTIMIZATION TO CLINICAL PROOF-OF-CONCEPT IN ASTHMA AND ALLERGIC RHINITIS.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 55. ISSUE 7. P. 2915-2931 54 76% 38
6 URADE, Y , HAYAISHI, O , (2000) BIOCHEMICAL, STRUCTURAL, GENETIC, PHYSIOLOGICAL, AND PATHOPHYSIOLOGICAL FEATURES OF LIPOCALIN-TYPE PROSTAGLANDIN D SYNTHASE.BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY. VOL. 1482. ISSUE 1-2. P. 259 -271 70 74% 200
7 ULVEN, T , KOSTENIS, E , (2006) TARGETING THE PROSTAGLANDIN D-2 RECEPTORS DP AND CRTH2 FOR TREATMENT OF INFLAMMATION.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 6. ISSUE 13. P. 1427 -1444 69 77% 26
8 URADE, Y , HAYAISHI, O , (2000) PROSTAGLANDIN D SYNTHASE: STRUCTURE AND FUNCTION.VITAMINS AND HORMONES - ADVANCES IN RESEARCH AND APPLICATIONS, VOL 58. VOL. 58. ISSUE . P. 89 -120 90 58% 167
9 PETTIPHER, R , (2008) THE ROLES OF THE PROSTAGLANDIN D-2 RECEPTORS DP1 AND CRTH2 IN PROMOTING ALLERGIC RESPONSES.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 153. ISSUE . P. S191 -S199 56 62% 81
10 CROSIGNANI, S , PRETRE, A , JORAND-LEBRUN, C , FRABOULET, G , SEENISAMY, J , AUGUSTINE, JK , MISSOTTEN, M , HUMBERT, Y , CLEVA, C , ABLA, N , ET AL (2011) DISCOVERY OF POTENT, SELECTIVE, AND ORALLY BIOAVAILABLE ALKYNYLPHENOXYACETIC ACID CRTH2 (DP2) RECEPTOR ANTAGONISTS FOR THE TREATMENT OF ALLERGIC INFLAMMATORY DISEASES.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 54. ISSUE 20. P. 7299 -7317 40 89% 16

Classes with closest relation at Level 1


Rank Class id link
1 5984 PROSTANOID RECEPTORS//EP3 RECEPTOR//IP RECEPTOR
2 5985 15D PGJ2//15 DEOXY DELTA12 14 PROSTAGLANDIN J2//CYCLOPENTENONE PROSTAGLANDINS
3 13000 ARACHIDONIC ACID//LEUKOTRIENE C 4 SYNTHESIS DEFICIENCY//5 8 1 14 EICOSATETRAYNOIC ACID
4 26020 ADRENOMEDULLARY OUTFLOW//SYMPATHO ADRENOMEDULLARY OUTFLOW//CENTRAL ADRENOMEDULLARY OUTFLOW
5 19756 MPGES 1//PROSTAGLANDIN E SYNTHASE//MPGES 1 INHIBITORS
6 3898 THROMBOXANE A2 RECEPTOR//THROMBOXANE A2//THROMBOXANE RECEPTOR
7 12400 MED BIOCHEM KURAMOTO CHO//PHARMACEUT S KITA KU//IMMUNOADSORPTION COLUMN
8 32609 ANGIOTENSIN IMMUNOREACTIVITY//CAROTID OCCLUSION RESPONSES//CAT SOLEUS MUSCLE
9 22658 BETA CASOMORPHIN//BETA CASOMORPHIN 7//ALPHA CASOZEPINE
10 11008 LATE PHASE RESPONSE//TYB 2285//LATE ASTHMATIC RESPONSE

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