Jonas Adler: AlphaFold 3

Abstract

AlphaFold 3 is a substantially updated model which is capable of joint structure prediction of complexes including proteins, nucleic acids, small molecules, ions, and modified residues. The new AlphaFold model demonstrates improved accuracy over many previous specialised tools: greater accuracy on protein-ligand interactions than state of the art docking tools, higher accuracy on protein-nucleic acid interactions than nucleic-acid-specific predictors, and significantly higher antibody-antigen prediction accuracy than AlphaFold-Multimer. I'll describe the new diffusion-based architecture in depth and discuss progress that made it possible to model a much wider range of structural biology.