Mammaliecellteknologi

The course teaches theory and methodology in the field of cell technology applied to animal cells.

Theoretical concepts included

• basic techniques for animal cell culture in shake flasks and small-scale bioreactors
• description and use of stable expression systems (cell lines)
• overview of animal cell metabolism during cultivation, and its application in process design
• aspects concerning commercial production such as patient safety and regulatory compliance
• cells as products
• application of knowledge from the course to develop and design culture processes

The student also receives practical training in

• developing a process flow chart and strategy for cell culturing
• choosing an appropriate cell line and expression system
• developing a culture process for industrial application (scale-up constraints)
• understanding the concept of "Good Manufacturing Practice" (GMP)
• deciding on patient safety level and from that design a suitable process

Upon completion of the course, the course participant is expected to be able to
- demonstrate knowledge of key theoretical concepts and basic methodology regarding the cultivation process of animal cells, as well as skills in communicating, reviewing, analyzing, and discussing the course topics (ÖVN1)
- demonstrate the ability to use acquired knowledge to independently design, motivate and present strategies for animal cell culture process in order to manufacture a therapeutic biologics (PRO1)
- demonstrate a basic understanding of the possibilities and limitations of the application of animal cell-culture techniques for the development of therapeutic biologics, and reflect on their use in a sustainable and ethical perspective (PRO1)