Publications by Veronique Chotteau

Peer reviewed

Articles

[1]

Y. Wang et al., "Iterative learning robust optimization - with application to medium optimization of CHO cell cultivation in continuous monoclonal antibody production," Journal of Process Control, vol. 137, 2024.

[2]

I. F. Pinto, V. Chotteau and A. Russom, "Microfluidic Cartridge for Bead-Based Affinity Assays," Methods in Molecular Biology, vol. 2804, pp. 127-138, 2024.

[3]

L. Dewasme, M. Mäkinen and V. Chotteau, "Multivariable robust tube-based nonlinear model predictive control of mammalian cell cultures," Computers and Chemical Engineering, vol. 183, 2024.

[4]

H. Schwarz et al., "Optimization of medium with perfusion microbioreactors for high density CHO cell cultures at very low renewal rate aided by design of experiments," Biotechnology and Bioengineering, vol. 120, no. 9, pp. 2523-2541, 2023.

[5]

L. Dewasme, M. Mäkinen and V. Chotteau, "Practical data-driven modeling and robust predictive control of mammalian cell fed-batch process," Computers and Chemical Engineering, vol. 171, 2023.

[6]

M. Pappenreiter et al., "Product sieving of mAb and its high molecular weight species in different modes of ATF and TFF perfusion cell cultures," Journal of chemical technology and biotechnology (1986), vol. 98, no. 7, pp. 1658-1672, 2023.

[7]

N. Ihling et al., "Scale‐down of CHO cell cultivation from shake flasks based on oxygen mass transfer allows application of parallelized, non‐invasive, and time‐resolved monitoring of the oxygen transfer rate in 48‐well microtiter plates," Biotechnology Journal, vol. 18, no. 11, 2023.

[8]

M. Moradi et al., "Autophagy and intracellular product degradation genes identified by systems biology analysis reduce aggregation of bispecific antibody in CHO cells," New Biotechnology, vol. 68, pp. 68-76, 2022.

[9]

S. Mikkonen et al., "Capillary and microchip electrophoresis method development for amino acid monitoring during biopharmaceutical cultivation," Biotechnology Journal, 2022.

[10]

J. Scheffel et al., "Design of an integrated continuous downstream process for acid-sensitive monoclonal antibodies based on a calcium-dependent Protein A ligand," Journal of Chromatography A, vol. 1664, pp. 462806-462806, 2022.

[11]

A. Yousefi-Darani et al., "Generic Chemometric Models for Metabolite Concentration Prediction Based on Raman Spectra," Sensors, vol. 22, no. 15, 2022.

[12]

M. Malm et al., "Harnessing secretory pathway differences between HEK293 and CHO to rescue production of difficult to express proteins," Metabolic engineering, vol. 72, pp. 171-187, 2022.

[13]

H. Schwarz et al., "Integrated continuous biomanufacturing on pilot scale for acid-sensitive monoclonal antibodies," Biotechnology and Bioengineering, 2022.

[14]

D. van der Burg et al., "Method development for mono- and disaccharides monitoring in cell culture medium by capillary and microchip electrophoresis," Electrophoresis, vol. 43, no. 9-10, pp. 922-929, 2022.

[15]

H. Schwarz et al., "Monitoring of amino acids and antibody N-glycosylation in high cell density perfusion culture based on Raman spectroscopy," Biochemical engineering journal, vol. 182, pp. 108426, 2022.

[16]

B. Ladd et al., "Proof-of-Concept of Continuous Transfection for Adeno-Associated Virus Production in Microcarrier-Based Culture," Processes, vol. 10, no. 3, 2022.

[17]

N. A. Brechmann et al., "Proof-of-Concept of a Novel Cell Separation Technology Using Magnetic Agarose-Based Beads," MAGNETOCHEMISTRY, vol. 8, no. 3, pp. 34, 2022.

[18]

R. Saghaleyni et al., "Report Enhanced metabolism and negative regulation of ER stress support higher erythropoietin production in HEK293 cells," Cell Reports, vol. 39, no. 11, pp. 110936, 2022.

[19]

D. Rodrigues et al., "An Integrated Approach for Modeling and Identification of Perfusion Bioreactors via Basis Flux Modes," Computers and Chemical Engineering, vol. 149, 2021.

[20]

N. A. Brechmann et al., "Antibody capture process based on magnetic beads from very high cell density suspension," Biotechnology and Bioengineering, vol. 118, no. 9, pp. 3499-3510, 2021.

[21]

L. Zhang et al., "Control of IgG glycosylation in CHO cell perfusion cultures by GReBA mathematical model supported by a novel targeted feed, TAFE," Metabolic engineering, vol. 65, pp. 135-145, 2021.

[22]

I. F. Pinto et al., "Knowing more from less: miniaturization of ligand-binding assays and electrophoresis as new paradigms for at-line monitoring and control of mammalian cell bioprocesses," Current Opinion in Biotechnology, vol. 71, pp. 55-64, 2021.

[23]

G. Bastin, V. Chotteau and A. Vande Wouwer, "Metabolic flux analysis of VERO cells under various culture conditions," Processes, vol. 9, no. 12, 2021.

[24]

I. F. Pinto et al., "Multiplexed Microfluidic Cartridge for At-Line Protein Monitoring in Mammalian Cell Culture Processes for Biopharmaceutical Production," ACS Sensors, vol. 6, no. 3, pp. 842-851, 2021.

[25]

L. Zhang et al., "Probabilistic model by Bayesian network for the prediction of antibody glycosylation in perfusion and fed-batch cell cultures," Biotechnology and Bioengineering, vol. 118, no. 9, pp. 3447-3459, 2021.

[26]

S. Särnlund, Y. Jiang and V. Chotteau, "Process intensification to produce a difficult-to-express therapeutic enzyme by high cell density perfusion or enhanced fed-batch," Biotechnology and Bioengineering, vol. 118, no. 9, pp. 3533-3544, 2021.

[27]

C. Åstrand et al., "Assembly of FN-silk with laminin-521 to integrate hPSCs into a three-dimensional culture for neural differentiation," Biomaterials Science, vol. 8, no. 9, pp. 2514-2525, 2020.

[28]

M. Malm et al., "Evolution from adherent to suspension : systems biology of HEK293 cell line development," Scientific Reports, vol. 10, no. 1, 2020.

[29]

L. Zhang et al., "Glycan Residues Balance Analysis : A novel model for the N-linked glycosylation of IgG produced by CHO cells.," Metabolic engineering, vol. 57, pp. 118-128, 2020.

[30]

M. Wang et al., "Identification of nonlinear kinetics of macroscopic bio-reactions using multilinear Gaussian processes," Computers and Chemical Engineering, vol. 133, 2020.

[31]

C. Zhan et al., "Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells," iScience, vol. 23, no. 11, 2020.

[32]

J. Gomis-Fons et al., "Model-based design and control of a small-scale integrated continuous end-to-end mAb platform," Biotechnology progress (Print), 2020.

[33]

H. Schwarz et al., "Small-scale bioreactor supports high density HEK293 cell perfusion culture for the production of recombinant Erythropoietin," Journal of Biotechnology, vol. 309, pp. 44-52, 2020.

[34]

L. Zhang et al., "Combined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells," Journal of Biotechnology, vol. 289, pp. 71-79, 2019.

[35]

E. Hagrot et al., "Novel column generation-based optimization approach for poly-pathway kinetic model applied to CHO cell culture," Metabolic Engineering Communications, vol. 8, 2019.

[36]

N. A. Brechmann et al., "Pilot-scale process for magnetic bead purification of antibodies directly from non-clarified CHO cell culture," Biotechnology progress (Print), 2019.

[37]

C. Zhan et al., "Study of hydrodynamics in wave bioreactors by computational fluid dynamics reveals a resonance phenomenon," Chemical Engineering Science, vol. 193, pp. 53-65, 2019.

[38]

L. Zamani et al., "High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome," Biotechnology Journal, vol. 13, no. 10, 2018.

[39]

M. Leino et al., "Human embryonic stem cell dispersion in electrospun PCL fiber scaffolds by coating with laminin-521 and E-cadherin-Fc," Journal of Biomedical Materials Research. Part B - Applied biomaterials, vol. 106, no. 3, pp. 1226-1236, 2018.

[40]

E. Hagrot et al., "Retraction notice to “Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model – Application to amino acid depletion in CHO cell culture” (Journal of Biotechnology (2016) 228 (37–39)(S0168165616301213)(10.1016/j.jbiotec.2016.03.015))," Journal of Biotechnology, vol. 265, 2018.

[41]

R. Ravichandran et al., "Intelligent ECM mimetic injectable scaffolds based on functional collagen building blocks for tissue engineering and biomedical applications," RSC Advances, vol. 7, no. 34, pp. 21068-21078, 2017.

[42]

E. Hagrot et al., "Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model-Application to amino acid depletion in CHO cell culture," Journal of Biotechnology, vol. 259, pp. 235-247, 2017.

[43]

L. Al-Khalili et al., "Characterization of Human CD133+Cells in Biocompatible Poly(l-lactic acid) Electrospun Nano-Fiber Scaffolds," Journal of Biomaterials and Tissue Engineering, vol. 6, no. 12, pp. 959-966, 2016.

[44]

E. Hagrot et al., "RETRACTED: Poly-pathway model, a novel approach to simulate multiple metabolic states by reaction network-based model - Application to amino acid depletion in CHO cell culture," Journal of Biotechnology, vol. 228, pp. 37-49, 2016.

[45]

H. A. Oddsdottir et al., "Robustness analysis of elementary flux modes generated by column generation," Mathematical Biosciences, vol. 273, pp. 45-56, 2016.

[46]

Y. Zhang and V. Chotteau, "Observation of Chinese Hamster Ovary Cells retained inside the non-woven fiber matrix of the CellTank bioreactor," Data in Brief, vol. 5, pp. 586-588, 2015.

[47]

Y. Zhang et al., "Very high cell density perfusion of CHO cells anchored in a non-woven matrix-based bioreactor," Journal of Biotechnology, vol. 213, pp. 28-41, 2015.

[48]

H. Æ. Oddsdóttir et al., "On dynamically generating relevant elementary flux modes in a metabolic network using optimization," Journal of Mathematical Biology, 2014.

[49]

M.-F. Clincke et al., "Very high density of CHO cells in perfusion by ATF or TFF in WAVE bioreactor. Part I. Effect of the cell density on the process," Biotechnology progress (Print), vol. 29, no. 3, pp. 754-767, 2013.

[50]

M.-F. Clincke et al., "Very high density of Chinese hamster ovary cells in perfusion by alternating tangential flow or tangential flow filtration in WAVE bioreactorpart II : Applications for antibody production and cryopreservation," Biotechnology progress (Print), vol. 29, no. 3, pp. 768-777, 2013.

Conference papers

[51]

Y. Wang et al., "Model-based Medium Optimization Methodologies in High-cell Density Perfusion Culture," in Cell Culture Engineering XVIII, Cancun, Mexico, April 23-28 2023, 2023.

[52]

M. Pasquini et al., "A Lyapunov based heuristic to speed up convergence of a feedback optimization framework with experiment batches-application to bioprocess manufacturing," in IFAC PAPERSONLINE, 2022, pp. 135-140.

[53]

K. Colin, H. Hjalmarsson and V. Chotteau, "Gaussian process modeling of macroscopic kinetics : a better-tailored kernel for Monod-type kinetics," in 10th Vienna International Conference on Mathematical Modelling MATHMOD 2022 Vienna Austria, 27–29 July 2022, 2022, pp. 397-402.

[54]

Y. Wang et al., "Robust optimization with optimal experiment design - with application to continuous biopharmaceutical production," in IFAC PAPERSONLINE, 2022, pp. 234-241.

[55]

M. Wang et al., "Estimation of Heteroscedastic Multilinear Systems," in Proceedings of the IEEE Conference on Decision and Control, 2020, pp. 2875-2880.

[56]

M. Wang et al., "Unscented Bayes Methods for Hierarchical Gaussian Processes," in 2020 Australian and New Zealand control conference (ANZCC 2020), 2020, pp. 137-142.

[57]

M. Wang et al., "A multi-step least-squares method for nonlinear rational models," in Proceedings of the American Control Conference, 2019, pp. 4509-4514.

[58]

V. Chotteau and A. Lindqvist, "Study of the effect of high pH and alkali addition in a cultivation of Chinese Hamster Ovary cell," in Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), 2012, pp. 323-326.

[59]

V. Chotteau and H. Hjalmarsson, "Tuning of dissolved oxygen and pH PID control parameters in large scale bioreactor by lag control," in Proceedings of the 21st Annual Meeting of the European Society for Animal Cell Technology (ESACT), 2012, pp. 327-330.

[60]

M.-F. Clincke et al., "Study of a recombinant CHO cell line producing a monoclonal antibody by ATF or TFF external filter perfusion in a WAVE Bioreactor™," in BMC Proceedings, 2011, Volume 5, Supplement 8, P105, 2011, p. 105.

[61]

V. Chotteau and H. Hjalmarsson, "Tuning of dissolved oxygen and pH PID control parameters in large scale bioreactor by lag control," in Proceedings of the Cell Culture Engineering XI Conference, 2008.

Chapters in books

[62]

V. Chotteau, "Perfusion Processes," in Animal Cell Culture, Mohamed Al-Rubeai Ed., Switzerland Springer : Springer, 2015, pp. 407-443.

Non-peer reviewed

Articles

[63]

B. Ladd and V. Chotteau, "Suspension Like Scalability of AAV9 Production in Adherent Cells," Molecular Therapy, vol. 31, no. 4, pp. 721-721, 2023.

[64]

B. Ladd and V. Chotteau, "The Effect of Cell Density on the Plasmid Utilization for the Production of Adeno-Associated Virus via the Triple-Transfection Method," Molecular Therapy, vol. 31, no. 4, pp. 719-720, 2023.

[65]

M. Malm et al., "Improving targeting and yield of AAV by capsid and cell engineering," Human Gene Therapy, vol. 32, no. 19-20, pp. A119-A120, 2021.

[66]

A. Karadagi et al., "Human Hepatocyte Spheroids Show Plasticity-enabling Extended Culture and Pretransplant Conditioning," Transplantation, vol. 103, no. 9, pp. S5-S5, 2019.

[67]

J. G. Fons et al., "Small scale end-to-end mAb platform with a continuous, integrated and compact process," Abstracts of Papers of the American Chemical Society, vol. 257, 2019.

[68]

A. Castan et al., "Cultivation process intensification utilizing a WAVE Bioreactor (TM) for perfusion cell cultures," Abstracts of Papers of the American Chemical Society, vol. 245, 2013.

Conference papers

[69]

M.-F. Clincke et al., "Perfusion of an IgG producing CHO cell line at very high cell density by ATF or by TFF in WAVE Bioreactor™," in Bioprocessing Summit, Boston, MA, USA, Aug. 22-25, 2011 - Optimizing Cell Culture Technology, 2011.

[70]

M.-F. Clincke et al., "Perfusion of an IgG producing CHO cell line at very high cell density by ATF or by TFF in WAVE Bioreactor™," in HansonWade Conference Optimizing Cell Line Performance, July, 26-28, 2011, London, UK, 2011.

[71]

V. Chotteau et al., "Comparison of cultivation in Techne spinner, Bellco spinner, shake flask and T-flask of human embryonic stem cells," in Proceedings of the SBE's Second International Conference on Stem Cell Engineering, 2010.

[72]

V. Chotteau et al., "Development of a fed-batch process for the production of a recombinant protein X in CHO-GS system : Case study from the cell to reactor process ready for pilot scale cultivation," in Cells and Culture : Proceedings of the 20^th ESACT, 2010, pp. 723-725.

[73]

Y. Jiang, E. Svensson and V. Chotteau, "Improvement of a CHO Fed-Batch Process by Fortifying with Plant Peptones," in Cells and Culture : ESACT Proceedings, 2010, Volume 4, Part 3, 2010, pp. 281-284.

[74]

V. Chotteau et al., "Study of Alternating Tangential Flow filtration for perfusion and harvest in Chinese Hamster Ovary cells cultivation," in Proceedings of the Cell Culture Engineering Conference XII, April 25-30, 2010, Banff, Canada, 2010.

[75]

V. Chotteau, C. Wåhlgren and H. Pettersson, "Effect of Peptones and Study of Feeding Strategies in a CHO Based Fed-batch Process for the Production of a Human Monoclonal Antibody," in Cell Technology for Cell Products : Proceedings of the 19th ESACT Meeting, Harrogate, UK, June 5-8, 2005, 2007, pp. 371-374.