Anna Månberg

During the past ten years, Nilsson lab has developed and applied a bead-based affinity proteomics method allowing for both high-throughput and multiplex protein analysis in human body fluids. Using this, we now design project-specific protein panels and we can make use of the method’s full capacity in terms of multiplexing through a close collaboration with the Human Protein Atlas project providing antibodies to the majority of the human proteome. Collaborations with national and international clinicians and researchers who have aligned research interests allow access to large and well-characterised sample cohorts.

The overall aim of my research is to find proteins and protein profiles that can help us understand disease pathology with potential for clinical applications and patient stratification. The main focus is currently on amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Alzheimer’s disease (AD) but we also have ongoing studies and collaborations in the context of other neurological disorders. Subsequent data analysis is focused on finding associations of protein levels within and across these diseases making use of available information such as diagnosis and clinical phenotypes. We also apply a more data-driven approach where we move beyond the current clinically defined phenotypes in the search for novel patient subgroups.

Besides our efforts on neuroproteomics, I'm also involved in some of the ongoing research on autoimmunity and serology profiling in Nilsson lab utilising our in-house produced antigen microarrays.

Group members:
Sofia Bergström, researcher
August Jernbom Falk, researcher
Jennie Olofsson, research engineer
Sára Mravinacová, PhD student

Affiliation:
Div of Affinity Proteomics
Dept of Protein Science
School of Engineering Sciences in Chemistry, Biotechnology and Health (CBH)
KTH Royal Institute of Technology
SciLifeLab

Selected publications:

• Sára Mravinacová, Vilma Alanko, Sofia Bergström, Claire Bridel, Yolande Pijnenburg, Göran Hagman, Miia Kivipelto, Charlotte Teunissen, Peter Nilsson, Anna Matton, Anna Månberg (2024)CSF protein ratios with enhanced potential to reflect Alzheimer's disease pathology and neurodegeneration. Molecular neurodegeneration 19:  1.  Feb.
• Ulf Kläppe, Stefan Sennfält, Anikó Lovik, Anja Finn, Ulrika Bofaisal, Henrik Zetterberg, Kaj Blennow, Fredrik Piehl, Ivan Kmezic, Rayomand Press, Kristin Samuelsson, Anna Månberg, Fang Fang, Caroline Ingre (2024)Neurodegenerative biomarkers outperform neuroinflammatory biomarkers in amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis & frontotemporal degeneration 25:  1-2.  150-161 Feb.
• Sofia Bergström, Linn Öijerstedt, Julia Remnestål, Jennie Olofsson, Abbe Ullgren, Harro Seelaar, John C van Swieten, Matthis Synofzik, Raquel Sanchez-Valle, Fermin Moreno, Elizabeth Finger, Mario Masellis, Carmela Tartaglia, Rik Vandenberghe, Robert Laforce, Daniela Galimberti, Barbara Borroni, Chris R Butler, Alexander Gerhard, Simon Ducharme, Jonathan D Rohrer, Anna Månberg, Caroline Graff, Peter Nilsson (2021)A panel of CSF proteins separates genetic frontotemporal dementia from presymptomatic mutation carriers: a GENFI study. Molecular neurodegeneration 16:  1.  11.
• Anna Månberg, Nathan Skene, Folkert Sanders, Marta Trusohamn, Julia Remnestål, Anna Szczepińska, Inci Sevval Aksoylu, Peter Lönnerberg, Lwaki Ebarasi, Stefan Wouters, Manuela Lehmann, Jennie Olofsson, Inti von von Antequera, Aylin Domaniku, Maxim De Schaepdryver, Joke De Vocht, Koen Poesen, Mathias Uhlén, Jasper Anink, Caroline Mijnsbergen, Hermieneke Vergunst-Bosch, Annemarie Hübers, Ulf Kläppe, Elena Rodriguez-Vieitez, Jonathan D Gilthorpe, Eva Hedlund, Robert A Harris, Eleonora Aronica, Philip Van Damme, Albert Ludolph, Jan Veldink, Caroline Ingre, Peter Nilsson, Sebastian A Lewandowski (2021)Altered perivascular fibroblast activity precedes ALS disease onset. Nature medicine 27:  4.  640-646 04.
• Julia Remnestål, Sofia Bergström, Jennie Olofsson, Evelina Sjöstedt, Mathias Uhlén, Kaj Blennow, Henrik Zetterberg, Anna Zettergren, Silke Kern, Ingmar Skoog, Peter Nilsson, Anna Månberg (2021)Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.Alzheimer's research & therapy 13:  1.  03.
• Elisa Pin, Ronald Sjöberg, Eni Andersson, Cecilia Hellström, Jennie Olofsson, August Jernbom Falk, Sofia Bergström, Julia Remnestål, David Just, Peter Nilsson, Anna Månberg (2019)Array-Based Profiling of Proteins and Autoantibody Repertoires in CSF.Methods in molecular biology (Clifton, N.J.) 2044:  303-318.

With funding from:

• Börje Salmings ALS stiftelse
• Ulla-Carin Lindquists stiftelse för ALS-forskning
• Multi‐omics Interdisciplinary Research Integration to Address DEmentia diagnosis (MIRIADE) The European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860197.
• Demensfonden
• Alzheimerfonden
• Hjärnfonden
• Åhlénstiftelsen