Class information for:
Level 1: EMBRYONIC STEM CELL TEST//WHOLE EMBRYO CULTURE//EMBRYOTOXICITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
8796 1216 35.0 50%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
547 3       ACETAMINOPHEN//CARBON MONOXIDE POISONING//POISONING 18371
2640 2             EMBRYONIC STEM CELL TEST//GLYCOL ETHERS//2 BUTOXYETHANOL 3504
8796 1                   EMBRYONIC STEM CELL TEST//WHOLE EMBRYO CULTURE//EMBRYOTOXICITY 1216

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 EMBRYONIC STEM CELL TEST authKW 1255465 5% 83% 60
2 WHOLE EMBRYO CULTURE authKW 327910 4% 28% 46
3 EMBRYOTOXICITY authKW 293054 6% 16% 74
4 TERATOLOGY journal 216262 11% 7% 129
5 HLTH RISK ANAL TOXICOL GRAT address 193147 1% 77% 10
6 ALTERNATIVE TEST METHOD authKW 189885 1% 69% 11
7 TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS journal 155535 6% 9% 69
8 VISCERAL YOLK SAC authKW 141437 1% 43% 13
9 EMBRYONIC STEM CELL TEST EST authKW 136705 1% 78% 7
10 DEVELOPMENTAL TOXICITY authKW 118896 5% 7% 66

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 48339 59% 0% 719
2 Developmental Biology 10545 19% 0% 230
3 Reproductive Biology 2677 9% 0% 115
4 Anatomy & Morphology 1419 5% 0% 59
5 Pharmacology & Pharmacy 603 15% 0% 185
6 Genetics & Heredity 498 10% 0% 118
7 Oncology 205 9% 0% 107
8 Medicine, Research & Experimental 61 4% 0% 47
9 Obstetrics & Gynecology 56 3% 0% 35
10 Integrative & Complementary Medicine 38 1% 0% 10

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 HLTH RISK ANAL TOXICOL GRAT 193147 1% 77% 10
2 ZEBET 98669 1% 30% 13
3 DOCUMENTAT EVALUAT ALTERNAT METHODS ANIM EX 66957 0% 67% 4
4 HLTH PROTECT 55019 3% 6% 37
5 GERMAN FED RISK ASSESSMENT BFR 50219 0% 100% 2
6 KTL FINLAND 50219 0% 100% 2
7 ECVAM 36435 1% 9% 17
8 ABT NICHTKLIN ARZNEIMITTELSICHERHEIT 25110 0% 100% 1
9 ALTERNAT ANIM TESTING ZEBET 25110 0% 100% 1
10 BIOL DEV EXPT TOXICOL 25110 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TERATOLOGY 216262 11% 7% 129
2 TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS 155535 6% 9% 69
3 REPRODUCTIVE TOXICOLOGY 56216 6% 3% 75
4 TOXICOLOGY IN VITRO 45962 7% 2% 89
5 BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY 19389 2% 4% 20
6 ATLA-ALTERNATIVES TO LABORATORY ANIMALS 15391 2% 2% 29
7 FUNDAMENTAL AND APPLIED TOXICOLOGY 6814 2% 1% 24
8 ARCHIVES OF TOXICOLOGY 6243 3% 1% 33
9 TOXICOLOGY AND APPLIED PHARMACOLOGY 5834 4% 0% 48
10 JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY 5293 1% 2% 14

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 EMBRYONIC STEM CELL TEST 1255465 5% 83% 60 Search EMBRYONIC+STEM+CELL+TEST Search EMBRYONIC+STEM+CELL+TEST
2 WHOLE EMBRYO CULTURE 327910 4% 28% 46 Search WHOLE+EMBRYO+CULTURE Search WHOLE+EMBRYO+CULTURE
3 EMBRYOTOXICITY 293054 6% 16% 74 Search EMBRYOTOXICITY Search EMBRYOTOXICITY
4 ALTERNATIVE TEST METHOD 189885 1% 69% 11 Search ALTERNATIVE+TEST+METHOD Search ALTERNATIVE+TEST+METHOD
5 VISCERAL YOLK SAC 141437 1% 43% 13 Search VISCERAL+YOLK+SAC Search VISCERAL+YOLK+SAC
6 EMBRYONIC STEM CELL TEST EST 136705 1% 78% 7 Search EMBRYONIC+STEM+CELL+TEST+EST Search EMBRYONIC+STEM+CELL+TEST+EST
7 DEVELOPMENTAL TOXICITY 118896 5% 7% 66 Search DEVELOPMENTAL+TOXICITY Search DEVELOPMENTAL+TOXICITY
8 HISTIOTROPHIC NUTRITION 104622 0% 83% 5 Search HISTIOTROPHIC+NUTRITION Search HISTIOTROPHIC+NUTRITION
9 EMBRYOTOXIC POTENTIAL 75329 0% 100% 3 Search EMBRYOTOXIC+POTENTIAL Search EMBRYOTOXIC+POTENTIAL
10 IN VITRO EMBRYOTOXICITY TEST 75329 0% 100% 3 Search IN+VITRO+EMBRYOTOXICITY+TEST Search IN+VITRO+EMBRYOTOXICITY+TEST

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 FLICK, B , KLUG, S , (2006) WHOLE EMBRYO CULTURE: AN IMPORTANT TOOL IN DEVELOPMENTAL TOXICOLOGY TODAY.CURRENT PHARMACEUTICAL DESIGN. VOL. 12. ISSUE 12. P. 1467 -1488 88 49% 19
2 LOUISSE, J , VERWEI, M , WOUTERSEN, RA , BLAAUBOER, BJ , RIETJENS, IMCM , (2012) TOWARD IN VITRO BIOMARKERS FOR DEVELOPMENTAL TOXICITY AND THEIR EXTRAPOLATION TO THE IN VIVO SITUATION.EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY. VOL. 8. ISSUE 1. P. 11 -27 56 57% 8
3 LEE, HY , INSELMAN, AL , KANUNGO, J , HANSEN, DK , (2012) ALTERNATIVE MODELS IN DEVELOPMENTAL TOXICOLOGY.SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE. VOL. 58. ISSUE 1. P. 10 -22 42 59% 14
4 THEUNISSEN, PT , PIERSMA, AH , (2012) INNOVATIVE APPROACHES IN THE EMBRYONIC STEM CELL TEST (EST).FRONTIERS IN BIOSCIENCE-LANDMARK. VOL. 17. ISSUE . P. 1965 -1975 37 67% 3
5 FAUSTMAN, EM , (1988) SHORT-TERM TESTS FOR TERATOGENS.MUTATION RESEARCH. VOL. 205. ISSUE 1-4. P. 355-384 79 56% 26
6 MARSHALL, VA , JOHNSON, KJ , MOORE, NP , RASOULPOUR, RJ , TORNESI, B , CARNEY, EW , (2015) COMPARATIVE RESPONSE OF RAT AND RABBIT CONCEPTUSES IN VITRO TO INHIBITORS OF HISTIOTROPHIC NUTRITION.BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. VOL. 104. ISSUE 1. P. 1 -10 23 79% 0
7 THOMSON, J , JOHNSON, K , CHAPIN, R , STEDMAN, D , KUMPF, S , OZOLINS, TRS , (2011) NOT A WALK IN THE PARK: THE ECVAM WHOLE EMBRYO CULTURE MODEL CHALLENGED WITH PHARMACEUTICALS AND ATTEMPTED IMPROVEMENTS WITH RANDOM FOREST DESIGN.BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY. VOL. 92. ISSUE 2. P. 111 -121 19 95% 7
8 ROMERO, AC , DEL RIO, E , VILANOVA, E , SOGORB, MA , (2015) RNA TRANSCRIPTS FOR THE QUANTIFICATION OF DIFFERENTIATION ALLOW MARKED IMPROVEMENTS IN THE PERFORMANCE OF EMBRYONIC STEM CELL TEST (EST).TOXICOLOGY LETTERS. VOL. 238. ISSUE 3. P. 60 -69 19 86% 0
9 SEILER, AEM , SPIELMANN, H , (2011) THE VALIDATED EMBRYONIC STEM CELL TEST TO PREDICT EMBRYOTOXICITY IN VITRO.NATURE PROTOCOLS. VOL. 6. ISSUE 7. P. 961 -978 23 61% 78
10 SOGORB, MA , PAMIES, D , DE LAPUENTE, J , ESTEVAN, C , ESTEVEZ, J , VILANOVA, E , (2014) AN INTEGRATED APPROACH FOR DETECTING EMBRYOTOXICITY AND DEVELOPMENTAL TOXICITY OF ENVIRONMENTAL CONTAMINANTS USING IN VITRO ALTERNATIVE METHODS.TOXICOLOGY LETTERS. VOL. 230. ISSUE 2. P. 356 -367 30 46% 15

Classes with closest relation at Level 1


Rank Class id link
1 21691 EXPT TERATOL UNIT//WAVY RIBS//GREY ZONE ANOMALIES
2 32955 EMBRYOL TERATOL//MATERNAL IMMUNE STIMULATION//FETOMATERNAL IMMUNOREACTIVITY
3 32822 AGING LESIONS//BIOCERANNICS//BIOCHEM CHOCIMSKA 5
4 37631 MICROAEROPHILIC//JOURNAL OF CLINICAL CHEMISTRY AND CLINICAL BIOCHEMISTRY//IMMUNOPHARMACOLOGY
5 14023 COMPUTAT TOXICOL//ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION//CAAT
6 25392 SUICIDE ATTEMPT DURING PREGNANCY//HUMAN GENET TERATOL//PREGNANCY AGE
7 34433 CONGENITAL MIDLINE CERVICAL CLEFT//MIDLINE CERVICAL CLEFT//BENDIOCARB
8 14141 GLYCOL ETHERS//2 BUTOXYETHANOL//BUTOXYACETIC ACID
9 4849 ANTIEPILEPTIC DRUGS//TERATOGENICITY//KERALA REGISTRY EPILEPSY PREGNANCY
10 34542 THIABENDAZOLE//2 PARA SUBSTITUTED PHENYLTHIAZOLES//4 CHLORO O PHENYLENE DIAMINE

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