Class information for:
Level 1: GATA4//NKX25//HOLT ORAM SYNDROME

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
7832 1322 45.2 89%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
27 3       DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2 109777
2233 2             HEART DEVELOPMENT//NKX25//CARDIAC DEVELOPMENT 4768
7832 1                   GATA4//NKX25//HOLT ORAM SYNDROME 1322

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GATA4 authKW 1123795 9% 41% 119
2 NKX25 authKW 862011 7% 41% 90
3 HOLT ORAM SYNDROME authKW 754327 3% 73% 45
4 GATA6 authKW 540584 4% 44% 53
5 TBX5 authKW 293231 3% 32% 40
6 CSX NKX25 authKW 184770 1% 100% 8
7 DEV DIFFERENCIAT CARDIAQUES address 164967 1% 71% 10
8 CARDIAC DEV DIFFERENTIAT address 141463 1% 88% 7
9 HAND1 authKW 130094 1% 43% 13
10 LRRC10 authKW 118779 0% 86% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Developmental Biology 8823 17% 0% 220
2 Genetics & Heredity 3778 23% 0% 304
3 Cardiac & Cardiovascular System 2243 17% 0% 226
4 Cell Biology 1517 19% 0% 248
5 Biochemistry & Molecular Biology 971 26% 0% 339
6 Anatomy & Morphology 403 3% 0% 34
7 Pediatrics 261 6% 0% 77
8 Medicine, Research & Experimental 243 6% 0% 82
9 Peripheral Vascular Diseases 171 4% 0% 54
10 Biophysics 92 4% 0% 55

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DEV DIFFERENCIAT CARDIAQUES 164967 1% 71% 10
2 CARDIAC DEV DIFFERENTIAT 141463 1% 88% 7
3 PUBL CENT 105576 1% 57% 8
4 CHARLIE E MIDT MED 102878 1% 64% 7
5 DEV DIFFERENCIAT CARDIAQ 73906 0% 80% 4
6 PROGRAM DEV REPROD BIOL 70201 1% 20% 15
7 SHANGHAI CHEST HOSP 62906 3% 6% 43
8 BEIJING PAEDIAT 46192 0% 100% 2
9 EXTRACORPORAL CIRCULAT 46192 0% 100% 2
10 UNIT CARDIAC GROWTH DIFFERENTIAT 46192 0% 100% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CIRCULATION-CARDIOVASCULAR GENETICS 5149 1% 2% 12
2 DEVELOPMENTAL BIOLOGY 5023 4% 0% 55
3 PEDIATRIC CARDIOLOGY 3459 2% 1% 25
4 DEVELOPMENTAL DYNAMICS 3066 2% 1% 25
5 DEVELOPMENT 2718 3% 0% 39
6 AMERICAN JOURNAL OF MEDICAL GENETICS PART A 2666 2% 0% 26
7 EUROPEAN JOURNAL OF MEDICAL GENETICS 1629 1% 1% 9
8 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 1493 1% 0% 19
9 TRENDS IN CARDIOVASCULAR MEDICINE 1452 1% 1% 9
10 MOLECULAR AND CELLULAR BIOLOGY 1364 3% 0% 37

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GATA4 1123795 9% 41% 119 Search GATA4 Search GATA4
2 NKX25 862011 7% 41% 90 Search NKX25 Search NKX25
3 HOLT ORAM SYNDROME 754327 3% 73% 45 Search HOLT+ORAM+SYNDROME Search HOLT+ORAM+SYNDROME
4 GATA6 540584 4% 44% 53 Search GATA6 Search GATA6
5 TBX5 293231 3% 32% 40 Search TBX5 Search TBX5
6 CSX NKX25 184770 1% 100% 8 Search CSX+NKX25 Search CSX+NKX25
7 HAND1 130094 1% 43% 13 Search HAND1 Search HAND1
8 LRRC10 118779 0% 86% 6 Search LRRC10 Search LRRC10
9 HEART DEVELOPMENT 117258 5% 8% 63 Search HEART+DEVELOPMENT Search HEART+DEVELOPMENT
10 EHAND 103930 0% 75% 6 Search EHAND Search EHAND

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 MCCULLEY, DJ , BLACK, BL , (2012) TRANSCRIPTION FACTOR PATHWAYS AND CONGENITAL HEART DISEASE.HEART DEVELOPMENT. VOL. 100. ISSUE . P. 253-277 89 47% 95
2 PRENDIVILLE, T , JAY, PY , PU, WT , (2014) INSIGHTS INTO THE GENETIC STRUCTURE OF CONGENITAL HEART DISEASE FROM HUMAN AND MURINE STUDIES ON MONOGENIC DISORDERS.COLD SPRING HARBOR PERSPECTIVES IN MEDICINE. VOL. 4. ISSUE 10. P. - 68 77% 1
3 AKAZAWA, H , KOMURO, I , (2005) CARDIAC TRANSCRIPTION FACTOR CSX/NKX2-5: ITS ROLE IN CARDIAC DEVELOPMENT AND DISEASES.PHARMACOLOGY & THERAPEUTICS. VOL. 107. ISSUE 2. P. 252-268 92 61% 102
4 PENG, T , WANG, L , ZHOU, SF , LI, XT , (2010) MUTATIONS OF THE GATA4 AND NKX2.5 GENES IN CHINESE PEDIATRIC PATIENTS WITH NON-FAMILIAL CONGENITAL HEART DISEASE.GENETICA. VOL. 138. ISSUE 11-12. P. 1231 -1240 54 87% 25
5 YUAN, F , QIU, XB , LI, RG , QU, XK , WANG, J , XU, YJ , LIU, X , FANG, WY , YANG, YQ , LIAO, DN , (2015) A NOVEL NKX2-5 LOSS-OF-FUNCTION MUTATION PREDISPOSES TO FAMILIAL DILATED CARDIOMYOPATHY AND ARRHYTHMIAS.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. VOL. 35. ISSUE 2. P. 478 -486 53 66% 7
6 PETERKIN, T , GIBSON, A , LOOSE, M , PATIENT, R , (2005) THE ROLES OF GATA-4,-5 AND-6 IN VERTEBRATE HEART DEVELOPMENT.SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. VOL. 16. ISSUE 1. P. 83-94 60 69% 100
7 PIKKARAINEN, S , TOKOLA, H , KERKELA, R , RUSKOAHO, H , (2004) GATA TRANSCRIPTION FACTORS IN THE DEVELOPING AND ADULT HEART.CARDIOVASCULAR RESEARCH. VOL. 63. ISSUE 2. P. 196-207 72 51% 189
8 MOLKENTIN, JD , (2000) THE ZINC FINGER-CONTAINING TRANSCRIPTION FACTORS GATA-4,-5, AND-6 - UBIQUITOUSLY EXPRESSED REGULATORS OF TISSUE-SPECIFIC GENE EXPRESSION.JOURNAL OF BIOLOGICAL CHEMISTRY. VOL. 275. ISSUE 50. P. 38949 -38952 53 61% 528
9 QIN, XY , XING, QN , MA, LM , MENG, HH , LIU, YM , PANG, SC , YAN, B , (2012) GENETIC ANALYSIS OF AN ENHANCER OF THE NKX2-5 GENE IN VENTRICULAR SEPTAL DEFECTS.GENE. VOL. 508. ISSUE 1. P. 106-109 45 79% 5
10 WANG, J , FANG, M , LIU, XY , XIN, YF , LIU, ZM , CHEN, XZ , WANG, XZ , FANG, WY , LIU, X , YANG, YQ , (2011) A NOVEL GATA4 MUTATION RESPONSIBLE FOR CONGENITAL VENTRICULAR SEPTAL DEFECTS.INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. VOL. 28. ISSUE 4. P. 557-564 42 82% 9

Classes with closest relation at Level 1


Rank Class id link
1 1801 HEART DEVELOPMENT//EPICARDIUM//SECOND HEART FIELD
2 14203 GATA 1//GATA2//EDAG
3 23280 TBX3//TBX2//BRACHYURY
4 10986 TINMAN//MYOBLAST FUSION//DORSAL VESSEL
5 16802 MEF2C//MEF2//MEF2D
6 33061 CITED2//CITED//MELANOCYTE SPECIFIC GENE MSG1
7 31526 ARID3B//JUMONJI//AT RICH INTERACTION DOMAIN
8 7460 CARDIOMYOCYTES//CARDIAC DIFFERENTIATION//STEM CELL REGENERAT MED CONSORTIUM
9 11071 LEFT RIGHT ASYMMETRY//LEFT RIGHT PATTERNING//NODAL
10 8526 CARDIAC HYPERTROPHY//HYPERTROPHY//CARDIAC MED SECT

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