Class information for:
Level 1: FAMILIAL HYPERCHOLESTEROLEMIA//FAMILIAL HYPERCHOLESTEROLAEMIA//LOW DENSITY LIPOPROTEIN RECEPTOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3640 1939 33.3 75%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
171 3       MONASCUS//CITRININ//MONASCUS PURPUREUS 58457
1649 2             LIPOPROTEINA//FAMILIAL HYPERCHOLESTEROLEMIA//APOLIPOPROTEINA 6893
3640 1                   FAMILIAL HYPERCHOLESTEROLEMIA//FAMILIAL HYPERCHOLESTEROLAEMIA//LOW DENSITY LIPOPROTEIN RECEPTOR 1939

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 FAMILIAL HYPERCHOLESTEROLEMIA authKW 4156495 27% 50% 527
2 FAMILIAL HYPERCHOLESTEROLAEMIA authKW 1340126 7% 61% 139
3 LOW DENSITY LIPOPROTEIN RECEPTOR authKW 394959 6% 23% 111
4 LDL RECEPTOR GENE authKW 383005 2% 81% 30
5 FAMILIAL DEFECTIVE APOLIPOPROTEIN B 100 authKW 367045 1% 90% 26
6 MIPOMERSEN authKW 330931 2% 62% 34
7 LDL RECEPTOR MUTATIONS authKW 320370 1% 88% 23
8 LOW DENSITY LIPOPROTEIN RECEPTOR GENE authKW 320370 1% 88% 23
9 LDL RECEPTOR authKW 313032 6% 16% 121
10 LOMITAPIDE authKW 281735 1% 62% 29

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Peripheral Vascular Diseases 9521 21% 0% 406
2 Cardiac & Cardiovascular System 8094 26% 0% 504
3 Genetics & Heredity 3787 19% 0% 374
4 Medical Laboratory Technology 2218 6% 0% 113
5 Medicine, General & Internal 938 12% 0% 225
6 Biochemistry & Molecular Biology 504 17% 0% 339
7 Medicine, Research & Experimental 297 6% 0% 112
8 Endocrinology & Metabolism 215 5% 0% 103
9 Hematology 59 3% 0% 49
10 Pharmacology & Pharmacy 41 6% 0% 107

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LIPID DISORDERS CLIN 190488 2% 37% 33
2 CARDIOMETAB SERV 156530 1% 76% 13
3 LIPID CLIN 118013 3% 12% 64
4 GRP INVEST CARDIOVASC 115946 0% 82% 9
5 UNIDADE ID 111971 0% 89% 8
6 BRITISH HEART FDN S 91359 2% 17% 35
7 LIPID CLIN HEART INCOR 82374 1% 35% 15
8 CARDIOVASC GENET 76009 4% 7% 73
9 INVEST MOL 68924 1% 26% 17
10 MRCC E HEART GRP 62985 0% 100% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF CLINICAL LIPIDOLOGY 90031 3% 9% 61
2 ATHEROSCLEROSIS 56986 10% 2% 196
3 ATHEROSCLEROSIS SUPPLEMENTS 18384 1% 6% 18
4 CLINICAL GENETICS 15959 4% 1% 72
5 CURRENT OPINION IN LIPIDOLOGY 12116 2% 2% 32
6 ARTERIOSCLEROSIS AND THROMBOSIS 11709 1% 3% 25
7 CLINICAL LIPIDOLOGY 10522 1% 4% 16
8 HUMAN MUTATION 8698 2% 1% 47
9 HUMAN GENETICS 7036 3% 1% 60
10 JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS 5610 1% 2% 20

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 FAMILIAL HYPERCHOLESTEROLEMIA 4156495 27% 50% 527 Search FAMILIAL+HYPERCHOLESTEROLEMIA Search FAMILIAL+HYPERCHOLESTEROLEMIA
2 FAMILIAL HYPERCHOLESTEROLAEMIA 1340126 7% 61% 139 Search FAMILIAL+HYPERCHOLESTEROLAEMIA Search FAMILIAL+HYPERCHOLESTEROLAEMIA
3 LOW DENSITY LIPOPROTEIN RECEPTOR 394959 6% 23% 111 Search LOW+DENSITY+LIPOPROTEIN+RECEPTOR Search LOW+DENSITY+LIPOPROTEIN+RECEPTOR
4 LDL RECEPTOR GENE 383005 2% 81% 30 Search LDL+RECEPTOR+GENE Search LDL+RECEPTOR+GENE
5 FAMILIAL DEFECTIVE APOLIPOPROTEIN B 100 367045 1% 90% 26 Search FAMILIAL+DEFECTIVE+APOLIPOPROTEIN+B+100 Search FAMILIAL+DEFECTIVE+APOLIPOPROTEIN+B+100
6 MIPOMERSEN 330931 2% 62% 34 Search MIPOMERSEN Search MIPOMERSEN
7 LDL RECEPTOR MUTATIONS 320370 1% 88% 23 Search LDL+RECEPTOR+MUTATIONS Search LDL+RECEPTOR+MUTATIONS
8 LOW DENSITY LIPOPROTEIN RECEPTOR GENE 320370 1% 88% 23 Search LOW+DENSITY+LIPOPROTEIN+RECEPTOR+GENE Search LOW+DENSITY+LIPOPROTEIN+RECEPTOR+GENE
9 LDL RECEPTOR 313032 6% 16% 121 Search LDL+RECEPTOR Search LDL+RECEPTOR
10 LOMITAPIDE 281735 1% 62% 29 Search LOMITAPIDE Search LOMITAPIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 JENSEN, HK , (2002) THE MOLECULAR GENETIC BASIS AND DIAGNOSIS OF FAMILIAL HYPERCHOLESTEROLEMIA IN DENMARK.DANISH MEDICAL BULLETIN. VOL. 49. ISSUE 4. P. 318-345 233 67% 21
2 AUSTIN, MA , HUTTER, CM , ZIMMERN, RL , HUMPHRIES, SE , (2004) GENETIC CAUSES OF MONOGENIC HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA: A HUGE PREVALENCE REVIEW.AMERICAN JOURNAL OF EPIDEMIOLOGY. VOL. 160. ISSUE 5. P. 407 -420 87 87% 185
3 DEDOUSSIS, GVZ , SCHMIDT, H , GENSCHEL, J , (2004) LDL-RECEPTOR MUTATIONS IN EUROPE.HUMAN MUTATION. VOL. 24. ISSUE 6. P. 443 -459 107 81% 40
4 MEHTA, R , ZUBIRAN, R , MARTAGON, AJ , VAZQUEZ-CARDENAS, A , SEGURA-KATO, Y , TUSIE-LUNA, MT , AGUILAR-SALINAS, CA , (2016) THE PANORAMA OF FAMILIAL HYPERCHOLESTEROLEMIA IN LATIN AMERICA: A SYSTEMATIC REVIEW.JOURNAL OF LIPID RESEARCH. VOL. 57. ISSUE 12. P. 2115 -2129 71 83% 0
5 PANG, J , LANSBERG, PJ , WATTS, GF , (2016) INTERNATIONAL DEVELOPMENTS IN THE CARE OF FAMILIAL HYPERCHOLESTEROLEMIA: WHERE NOW AND WHERE TO NEXT?.JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS. VOL. 23. ISSUE 5. P. 505 -519 68 86% 0
6 FOODY, JM , VISHWANATH, R , (2016) FAMILIAL HYPERCHOLESTEROLEMIA/AUTOSOMAL DOMINANT HYPERCHOLESTEROLEMIA: MOLECULAR DEFECTS, THE LDL-C CONTINUUM, AND GRADIENTS OF PHENOTYPIC SEVERITY.JOURNAL OF CLINICAL LIPIDOLOGY. VOL. 10. ISSUE 4. P. 970 -986 64 77% 1
7 SANTOS, RD , FRAUCHES, TS , CHACRA, APM , (2015) CASCADE SCREENING IN FAMILIAL HYPERCHOLESTEROLEMIA: ADVANCING FORWARD.JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS. VOL. 22. ISSUE 9. P. 869 -880 60 81% 3
8 WATTS, GF , GIDDING, S , WIERZBICKI, AS , TOTH, PP , ALONSO, R , BROWN, WV , BRUCKERT, E , DEFESCHE, J , LIN, KK , LIVINGSTON, M , ET AL (2014) INTEGRATED GUIDANCE ON THE CARE OF FAMILIAL HYPERCHOLESTEROLAEMIA FROM THE INTERNATIONAL FH FOUNDATION.INTERNATIONAL JOURNAL OF CARDIOLOGY. VOL. 171. ISSUE 3. P. 309 -325 79 48% 44
9 SOUTAR, AK , NAOUMOVA, RP , (2007) MECHANISMS OF DISEASE: GENETIC CAUSES OF FAMILIAL HYPERCHOLESTEROLEMIA.NATURE CLINICAL PRACTICE CARDIOVASCULAR MEDICINE. VOL. 4. ISSUE 4. P. 214-225 55 73% 232
10 ANDERSEN, LH , MISEREZ, AR , AHMAD, Z , ANDERSEN, RL , (2016) FAMILIAL DEFECTIVE APOLIPOPROTEIN B-100: A REVIEW.JOURNAL OF CLINICAL LIPIDOLOGY. VOL. 10. ISSUE 6. P. 1297 -1302 49 94% 0

Classes with closest relation at Level 1


Rank Class id link
1 9366 PCSK9//PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9//ALIROCUMAB
2 28605 PARTIAL ILEAL BYPASS//COMBINED HEART LIVER TRANSPLANT//HEART LIVER TRANSPLANTATION
3 21910 APOLIPOPROTEIN B GENE//APOB GENE//APOLIPOPROTEIN B
4 11649 LDL APHERESIS//LOW DENSITY LIPOPROTEIN APHERESIS//LIPOPROTEIN APHERESIS
5 35878 CHOLESTEROL CONTENT MODIFICATION//ELIMINATION OF HIV 1 INFECTED CELLS//HIGH ALTITUDE PHYSIOL EXPT PATHOL
6 17284 WHHL RABBIT//WHHLMI RABBIT//PATHOPHARMACOL UNIT
7 33824 MATERNAL HYPERCHOLESTEROLEMIA//GLC OXLDL//MTF 110
8 5586 CHOLESTEROL SCREENING//PL PREVENT CARDIOVASC MED//ATHEROSCLEROSIS IN YOUTH
9 10830 LRP1//LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN//VLDL RECEPTOR
10 24822 LIPOPROT UNIT//LIPOPROTEIN KINETICS//USC INRA NUTR ENDOCRINOL

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