Class information for:
Level 1: NOTCH1//NOTCH//GAMMA SECRETASE INHIBITOR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
3243 2030 50.2 95%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
27 3       DEVELOPMENTAL BIOLOGY//DEVELOPMENT//AGR2 109777
2542 2             CADASIL//NOTCH3//NOTCH 3755
3243 1                   NOTCH1//NOTCH//GAMMA SECRETASE INHIBITOR 2030

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NOTCH1 authKW 1204750 11% 35% 231
2 NOTCH authKW 777374 20% 13% 398
3 GAMMA SECRETASE INHIBITOR authKW 507806 4% 41% 83
4 NOTCH SIGNALING authKW 394404 7% 19% 140
5 JAGGED1 authKW 221118 3% 28% 53
6 NOTCH3 authKW 180466 3% 23% 53
7 NOTCH INHIBITOR authKW 133771 1% 68% 13
8 RO4929097 authKW 121824 0% 90% 9
9 NOTCH SIGNALING PATHWAY authKW 113340 1% 27% 28
10 NOTCH LIGANDS authKW 104044 1% 43% 16

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 12687 41% 0% 838
2 Cell Biology 3887 24% 0% 478
3 Hematology 2352 11% 0% 224
4 Immunology 1708 15% 0% 312
5 Medicine, Research & Experimental 735 8% 0% 166
6 Pathology 494 5% 0% 103
7 Cell & Tissue Engineering 458 1% 0% 30
8 Biochemistry & Molecular Biology 383 16% 0% 319
9 Developmental Biology 189 2% 0% 47
10 Genetics & Heredity 136 5% 0% 99

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MED GENET DEV BIOL 58669 1% 18% 22
2 FDN CA GRANDA IRCCS POLICLIN 33839 0% 75% 3
3 PROGRAM STEM CELL DEV BIOL 33839 0% 75% 3
4 CARDINAL BERNARDIN CANC 31024 1% 7% 29
5 KARL LANDSTEINER CYTOKINE TUMOUR MICROENVI 30081 0% 100% 2
6 ABRAMSON FAMILY CANC 25146 2% 3% 48
7 RADIOTHER Y MAASTRO GROW 22557 0% 50% 3
8 IMMUNOL PARASITOL 22328 1% 7% 20
9 LAUSANNE BRANCH 20581 1% 6% 24
10 USTER TRANSPLANTAT 20052 0% 67% 2

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 IMMUNITY 3643 1% 1% 29
2 BLOOD 3193 4% 0% 87
3 ONCOTARGET 2199 2% 0% 43
4 CANCER CELL 2188 1% 1% 15
5 ONCOLOGY REPORTS 2017 2% 0% 37
6 ONCOGENE 2004 2% 0% 50
7 CANCER RESEARCH 2001 4% 0% 74
8 JOURNAL OF IMMUNOLOGY 1468 4% 0% 75
9 LEUKEMIA 1407 1% 0% 27
10 ONCOLOGY LETTERS 1301 1% 0% 22

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 NOTCH1 1204750 11% 35% 231 Search NOTCH1 Search NOTCH1
2 NOTCH 777374 20% 13% 398 Search NOTCH Search NOTCH
3 GAMMA SECRETASE INHIBITOR 507806 4% 41% 83 Search GAMMA+SECRETASE+INHIBITOR Search GAMMA+SECRETASE+INHIBITOR
4 NOTCH SIGNALING 394404 7% 19% 140 Search NOTCH+SIGNALING Search NOTCH+SIGNALING
5 JAGGED1 221118 3% 28% 53 Search JAGGED1 Search JAGGED1
6 NOTCH3 180466 3% 23% 53 Search NOTCH3 Search NOTCH3
7 NOTCH INHIBITOR 133771 1% 68% 13 Search NOTCH+INHIBITOR Search NOTCH+INHIBITOR
8 RO4929097 121824 0% 90% 9 Search RO4929097 Search RO4929097
9 NOTCH SIGNALING PATHWAY 113340 1% 27% 28 Search NOTCH+SIGNALING+PATHWAY Search NOTCH+SIGNALING+PATHWAY
10 NOTCH LIGANDS 104044 1% 43% 16 Search NOTCH+LIGANDS Search NOTCH+LIGANDS

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 LEONG, KG , KARSAN, A , (2006) RECENT INSIGHTS INTO THE ROLE OF NOTCH SIGNALING IN TUMORIGENESIS.BLOOD. VOL. 107. ISSUE 6. P. 2223-2233 96 69% 296
2 RADTKE, F , FASNACHT, N , MACDONALD, HR , (2010) NOTCH SIGNALING IN THE IMMUNE SYSTEM.IMMUNITY. VOL. 32. ISSUE 1. P. 14-27 80 65% 198
3 SHANG, YL , SMITH, S , HU, XY , (2016) ROLE OF NOTCH SIGNALING IN REGULATING INNATE IMMUNITY AND INFLAMMATION IN HEALTH AND DISEASE.PROTEIN & CELL. VOL. 7. ISSUE 3. P. 159 -174 80 68% 3
4 NTZIACHRISTOS, P , LIM, JS , SAGE, J , AIFANTIS, I , (2014) FROM FLY WINGS TO TARGETED CANCER THERAPIES: A CENTENNIAL FOR NOTCH SIGNALING.CANCER CELL. VOL. 25. ISSUE 3. P. 318 -334 96 44% 83
5 ESPINOZA, I , MIELE, L , (2013) NOTCH INHIBITORS FOR CANCER TREATMENT.PHARMACOLOGY & THERAPEUTICS. VOL. 139. ISSUE 2. P. 95-110 113 45% 63
6 HUANG, TT , ZHOU, YH , CHENG, ASL , YU, J , TO, KF , KANG, W , (2016) NOTCH RECEPTORS IN GASTRIC AND OTHER GASTROINTESTINAL CANCERS: ONCOGENES OR TUMOR SUPPRESSORS?.MOLECULAR CANCER. VOL. 15. ISSUE . P. - 97 65% 0
7 SANDY, AR , MAILLARD, I , (2009) NOTCH SIGNALING IN THE HEMATOPOIETIC SYSTEM.EXPERT OPINION ON BIOLOGICAL THERAPY. VOL. 9. ISSUE 11. P. 1383 -1398 101 68% 28
8 GU, YS , MASIERO, M , BANHAM, AH , (2016) NOTCH SIGNALING: ITS ROLES AND THERAPEUTIC POTENTIAL IN HEMATOLOGICAL MALIGNANCIES.ONCOTARGET. VOL. 7. ISSUE 20. P. 29804 -29823 87 58% 3
9 YUAN, X , WU, H , XU, HX , XIONG, HH , CHU, Q , YU, SY , WU, GS , WU, KM , (2015) NOTCH SIGNALING: AN EMERGING THERAPEUTIC TARGET FOR CANCER TREATMENT.CANCER LETTERS. VOL. 369. ISSUE 1. P. 20 -27 63 74% 15
10 OLSAUSKAS-KUPRYS, R , ZLOBIN, A , OSIPO, C , (2013) GAMMA SECRETASE INHIBITORS OF NOTCH SIGNALING.ONCOTARGETS AND THERAPY. VOL. 6. ISSUE . P. 943 -955 78 62% 35

Classes with closest relation at Level 1


Rank Class id link
1 3238 NOTCH//NEUROGENIC GENES//SUPPRESSOR OF HAIRLESS
2 11708 DLL4//VASC PATTERNING//DELTA LIKE LIGAND 4
3 30013 ENDOCRINE SURG S//HASH1//CLIN SCI H4 750
4 26933 HAJDU CHENEY SYNDROME//ACROOSTEOLYSIS//SERPENTINE FIBULA POLYCYSTIC KIDNEY SYNDROME
5 9379 PAX5//EBF//LINEAGE COMMITMENT
6 10949 IKAROS//IKZF1//HOX11
7 24146 LYMPHOCYTE DEV UNIT//JIANPI BUSHEN PRESCRIPTION//SYDNEY CORD MARROW TRANSPLANT IL
8 160 CANCER STEM CELLS//CD133//SIDE POPULATION
9 19492 FBXW7//FBW7//FBXO7
10 23462 DLK1//CALLIPYGE//PREF 1

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