Class information for:
Level 1: ACRIVASTINE//METHAPYRILENE//ACRIVASTINE DETERMINATION

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
27473 229 24.0 55%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
686 3       HISTAMINE//HISTAMINE H 3 RECEPTOR//THIOPERAMIDE 8239
3951 2             NEFOPAM//ACRIVASTINE//METHAPYRILENE 757
27473 1                   ACRIVASTINE//METHAPYRILENE//ACRIVASTINE DETERMINATION 229

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ACRIVASTINE authKW 701485 5% 48% 11
2 METHAPYRILENE authKW 490931 4% 41% 9
3 ACRIVASTINE DETERMINATION authKW 266684 1% 100% 2
4 ASTEMIZOLE DETERMINATION authKW 266684 1% 100% 2
5 METHAPYRILENE HYDROCHLORIDE authKW 266684 1% 100% 2
6 ASTEMIZOLE authKW 229925 6% 13% 13
7 MEQUITAZINE authKW 192004 3% 24% 6
8 2 6 DICHLOROQUINONE 4 CHLOROIMIDE GIBBS REAGENT authKW 133342 0% 100% 1
9 3 METHYL 2 BENZO THIAZOLINONE authKW 133342 0% 100% 1
10 ANTIHISTAMINE ACRIVASTINE authKW 133342 0% 100% 1

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Toxicology 3697 38% 0% 87
2 Chemistry, Analytical 727 25% 0% 57
3 Pharmacology & Pharmacy 715 34% 0% 77
4 Spectroscopy 78 6% 0% 13
5 Chemistry, Medicinal 64 6% 0% 13
6 Oncology 62 10% 0% 24
7 Microscopy 52 2% 0% 4
8 Genetics & Heredity 35 7% 0% 15
9 Medicine, Legal 29 1% 0% 3
10 Biochemical Research Methods 18 4% 0% 9

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 CHEM CATALYSIS SUR E SCI 133342 0% 100% 1
2 ILLINOIS RACING BOARD 133342 0% 100% 1
3 PREDICT TOXICOL SCREENS EMERGING TECHNOL 133342 0% 100% 1
4 NONCLIN SAFETY NCS 66670 0% 50% 1
5 CONSUMER CARE EUROPE 44446 0% 33% 1
6 STRATEG TECHNOL DEV 44446 0% 33% 1
7 XINJIANG BINGTUAN GREEN PROC CHEM ENGN 44446 0% 33% 1
8 FOODS DRUGS S 41025 1% 15% 2
9 MICROSTRUCT STUDIES UNIT 33334 0% 25% 1
10 GEN PL TOXICOL 22222 0% 17% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 JOURNAL OF THE AMERICAN COLLEGE OF TOXICOLOGY 21487 4% 2% 10
2 CONNAISSANCE DES ARTS 6059 0% 5% 1
3 XENOBIOTICA 4158 5% 0% 11
4 FUNDAMENTAL AND APPLIED TOXICOLOGY 4032 3% 0% 8
5 JOURNAL OF ANALYTICAL TOXICOLOGY 3994 4% 0% 10
6 BIOMEDICAL AND ENVIRONMENTAL MASS SPECTROMETRY 2927 2% 1% 4
7 JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 1463 5% 0% 11
8 MUTATION RESEARCH 1320 4% 0% 9
9 AUSTRALIAN JOURNAL OF BIOLOGICAL SCIENCES 1112 1% 0% 2
10 CARCINOGENESIS 725 3% 0% 8

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ACRIVASTINE 701485 5% 48% 11 Search ACRIVASTINE Search ACRIVASTINE
2 METHAPYRILENE 490931 4% 41% 9 Search METHAPYRILENE Search METHAPYRILENE
3 ACRIVASTINE DETERMINATION 266684 1% 100% 2 Search ACRIVASTINE+DETERMINATION Search ACRIVASTINE+DETERMINATION
4 ASTEMIZOLE DETERMINATION 266684 1% 100% 2 Search ASTEMIZOLE+DETERMINATION Search ASTEMIZOLE+DETERMINATION
5 METHAPYRILENE HYDROCHLORIDE 266684 1% 100% 2 Search METHAPYRILENE+HYDROCHLORIDE Search METHAPYRILENE+HYDROCHLORIDE
6 ASTEMIZOLE 229925 6% 13% 13 Search ASTEMIZOLE Search ASTEMIZOLE
7 MEQUITAZINE 192004 3% 24% 6 Search MEQUITAZINE Search MEQUITAZINE
8 2 6 DICHLOROQUINONE 4 CHLOROIMIDE GIBBS REAGENT 133342 0% 100% 1 Search 2+6+DICHLOROQUINONE+4+CHLOROIMIDE+GIBBS+REAGENT Search 2+6+DICHLOROQUINONE+4+CHLOROIMIDE+GIBBS+REAGENT
9 3 METHYL 2 BENZO THIAZOLINONE 133342 0% 100% 1 Search 3+METHYL+2+BENZO+THIAZOLINONE Search 3+METHYL+2+BENZO+THIAZOLINONE
10 ANTIHISTAMINE ACRIVASTINE 133342 0% 100% 1 Search ANTIHISTAMINE+ACRIVASTINE Search ANTIHISTAMINE+ACRIVASTINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 KELLY, DW , HOLDER, CL , KORFMACHER, WA , GETEK, TA , LAY, JO , CASCIANO, DA , SHADDOCK, JG , DUHART, HM , SLIKKER, W , (1992) METABOLISM OF METHAPYRILENE BY FISCHER-344 RAT AND B6C3F1 MOUSE HEPATOCYTES.XENOBIOTICA. VOL. 22. ISSUE 12. P. 1367-1381 26 93% 11
2 HAMADEH, HK , KNIGHT, BL , HAUGEN, AC , SIEBER, S , AMIN, RP , BUSHEL, PR , STOLL, R , BLANCHARD, K , JAYADEV, S , TENNANT, RW , ET AL (2002) METHAPYRILENE TOXICITY: ANCHORAGE OF PATHOLOGIC OBSERVATIONS TO GENE EXPRESSION ALTERATIONS.TOXICOLOGIC PATHOLOGY. VOL. 30. ISSUE 4. P. 470-482 28 50% 73
3 BRAMBILLA, G , MATTIOLI, F , ROBBIANO, L , MARTELLI, A , (2011) GENOTOXICITY AND CARCINOGENICITY STUDIES OF ANTIHISTAMINES.ARCHIVES OF TOXICOLOGY. VOL. 85. ISSUE 10. P. 1173-1187 23 44% 4
4 KELLY, DW , HOLDER, CL , KORFMACHER, WA , SLIKKER, W , (1990) PLASMA ELIMINATION AND URINARY-EXCRETION OF METHAPYRILENE IN THE RAT.DRUG METABOLISM AND DISPOSITION. VOL. 18. ISSUE 6. P. 1018-1024 22 88% 5
5 ZHAO, F , (2013) FLOW INJECTION POST-CHEMILUMINESCENCE REACTION OF ASTEMIZOLE IN N-BROMOSUCCINIMIDE-CALCEIN SYSTEM AND ITS APPLICATION.ANALYTICAL LETTERS. VOL. 46. ISSUE 11. P. 1793 -1803 14 58% 2
6 GRAHAM, EE , WALSH, RJ , HIRST, CM , MAGGS, JL , MARTIN, S , WILD, MJ , WILSON, ID , HARDING, JR , KENNA, JG , PETER, RM , ET AL (2008) IDENTIFICATION OF THE THIOPHENE RING OF METHAPYRILENE AS A NOVEL BIOACTIVATION-DEPENDENT HEPATIC TOXICOPHORE.JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. VOL. 326. ISSUE 2. P. 657 -671 18 50% 14
7 KUMAR, A , DEVINENI, SR , DUBEY, SK , KUMAR, P , SRIVASTAVA, V , AMBULGEKAR, G , JAIN, M , GUPTA, DK , SINGH, G , KUMAR, R , ET AL (2017) IDENTIFICATION, SYNTHESIS AND STRUCTURAL CHARACTERIZATION OF PROCESS RELATED AND DEGRADATION IMPURITIES OF ACRIVASTINE AND VALIDATION OF HPLC METHOD.JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. VOL. 133. ISSUE . P. 15 -26 13 57% 0
8 ALGHAMDI, AH , (2008) SQUARE-WAVE ADSORPTIVE STRIPPING VOLTAMMETRIC DETERMINATION OF AN ANTIHISTAMINE DRUG ASTEMIZOLE.CHEMICAL PAPERS. VOL. 62. ISSUE 4. P. 339 -344 11 79% 4
9 KAMMERER, RC , SCHMITZ, DA , (1988) A COMPARATIVE INVITRO METABOLIC STUDY OF METHAPHENILENE AND PYRIBENZAMINE.XENOBIOTICA. VOL. 18. ISSUE 9. P. 1085-1096 20 91% 5
10 PRIESTLEY, CC , REGAN, S , PARK, BK , WILLIAMS, DP , (2011) THE GENOTOXIC POTENTIAL OF METHAPYRILENE USING THE ALKALINE COMET ASSAY IN VITRO AND IN VIVO.TOXICOLOGY. VOL. 290. ISSUE 2-3. P. 249-257 15 50% 4

Classes with closest relation at Level 1


Rank Class id link
1 27231 ANTIHISTAMINERGIC EFFECT//ATARAXIC//CA2 GATED K CHANNEL
2 14486 TOXICOGENOMICS//CELLULAR MOL TOXICOL//TOXICOGENOM INFORMAT PROJECT
3 21666 NON MITOCHONDRIAL PATHWAY//5HT3 AND 5HT4 RECEPTORS//AGONIST AND ANTAGONISTS
4 22120 CUNNINGHAMELLA BLAKESLEEANA//CUNNINGHAMELLA//PENICILLIUM CHERMESINUM
5 24491 DINITROSOPIPERAZINE DNPZ//N NITROSOGUANIDINIUM COMPOUNDS//SIMULATED GASTRIC JUICE SGJ
6 27122 BOUCHE VISAGE ENFANT//HOP UNIV NECKER 149//PCGS
7 15462 IN VITRO MITOGENIC STIMULATION//UMR 0938//URIDINE UPTAKE ASSAY
8 28024 DENAVERINE//N MONODEMETHYL DENAVERINE//ORPHENADRINE
9 12248 HYPEREMESIS GRAVIDARUM//NAUSEA AND VOMITING OF PREGNANCY//MORNING SICKNESS
10 2501 ANTIHISTAMINES//CETIRIZINE//LEVOCETIRIZINE

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