Class information for:
Level 1: GRAMICIDIN S//TYROCIDINE//HIGH ANTIBIOTIC ACTIVITY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23674 338 28.2 55%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
5 4 CHEMISTRY, ORGANIC//CHEMISTRY, INORGANIC & NUCLEAR//CHEMISTRY, MULTIDISCIPLINARY 1745167
534 3       PYRIMIDINOPHANES//SOLID PHASE SYNTHESIS//INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 19564
1200 2             PEPTAIBOL//FOLDAMERS//PEPTOIDS 9232
23674 1                   GRAMICIDIN S//TYROCIDINE//HIGH ANTIBIOTIC ACTIVITY 338

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GRAMICIDIN S authKW 1648981 11% 49% 37
2 TYROCIDINE authKW 464607 2% 86% 6
3 HIGH ANTIBIOTIC ACTIVITY authKW 451703 1% 100% 5
4 LOW HEMOLYTIC ACTIVITY authKW 451703 1% 100% 5
5 BIOPEP PEPTIDE GRP address 316185 2% 50% 7
6 SOLVENT MEDIATOR authKW 289089 1% 80% 4
7 CYCLIC ANTIMICROBIAL PEPTIDES authKW 271022 1% 100% 3
8 GRAMICIDIN S ANALOGS authKW 271022 1% 100% 3
9 GRATISIN authKW 271022 1% 100% 3
10 LOLOATIN C authKW 271022 1% 100% 3

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Chemistry, Medicinal 514 12% 0% 41
2 Biochemistry & Molecular Biology 429 32% 0% 108
3 Chemistry, Multidisciplinary 406 24% 0% 82
4 Biophysics 382 13% 0% 44
5 Chemistry, Analytical 283 14% 0% 46
6 Chemistry, Organic 237 13% 0% 45
7 Pharmacology & Pharmacy 71 11% 0% 37
8 Biochemical Research Methods 59 5% 0% 18
9 Microbiology 39 6% 0% 20
10 Crystallography 13 2% 0% 8

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 BIOPEP PEPTIDE GRP 316185 2% 50% 7
2 UNIDAD DIFRACC RAYOS X RIAIDT 271022 1% 100% 3
3 BIOMED MED PHYS 180681 1% 100% 2
4 INTEGRAL DINAM ESTRUCT BIOMOL JOSE R CARRAC 180673 2% 33% 6
5 UNIDAD RAYOS X RIAIDT 101630 1% 38% 3
6 BIOENGN MEASUREMENTS 90341 0% 100% 1
7 BUSISNESS UNIT BIOL CHEM PROTECT 90341 0% 100% 1
8 PEPTIDE LIPID INTERACT PEPTIDE TRANSPORT GRP 90341 0% 100% 1
9 PL CHEM ENGN TOBATA KU 90341 0% 100% 1
10 RS INFECT DIS 90341 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH 7055 4% 1% 14
2 BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 6497 11% 0% 36
3 JOURNAL OF PEPTIDE RESEARCH 4819 2% 1% 7
4 JAPANESE JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH 2793 1% 1% 4
5 BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES 2071 4% 0% 12
6 ANALYTICAL SCIENCES 996 3% 0% 9
7 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-PHYSICAL SCIENCES 935 1% 1% 2
8 ANTIBIOTIKI I MEDITSINSKAYA BIOTEKHNOLOGIYA 932 1% 1% 2
9 LETTERS IN PEPTIDE SCIENCE 726 1% 0% 2
10 BIOPOLYMERS 671 2% 0% 7

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 GRAMICIDIN S 1648981 11% 49% 37 Search GRAMICIDIN+S Search GRAMICIDIN+S
2 TYROCIDINE 464607 2% 86% 6 Search TYROCIDINE Search TYROCIDINE
3 HIGH ANTIBIOTIC ACTIVITY 451703 1% 100% 5 Search HIGH+ANTIBIOTIC+ACTIVITY Search HIGH+ANTIBIOTIC+ACTIVITY
4 LOW HEMOLYTIC ACTIVITY 451703 1% 100% 5 Search LOW+HEMOLYTIC+ACTIVITY Search LOW+HEMOLYTIC+ACTIVITY
5 SOLVENT MEDIATOR 289089 1% 80% 4 Search SOLVENT+MEDIATOR Search SOLVENT+MEDIATOR
6 CYCLIC ANTIMICROBIAL PEPTIDES 271022 1% 100% 3 Search CYCLIC+ANTIMICROBIAL+PEPTIDES Search CYCLIC+ANTIMICROBIAL+PEPTIDES
7 GRAMICIDIN S ANALOGS 271022 1% 100% 3 Search GRAMICIDIN+S+ANALOGS Search GRAMICIDIN+S+ANALOGS
8 GRATISIN 271022 1% 100% 3 Search GRATISIN Search GRATISIN
9 LOLOATIN C 271022 1% 100% 3 Search LOLOATIN+C Search LOLOATIN+C
10 AMPHIPHILIC BETA STRUCTURAL PEPTIDE 180681 1% 100% 2 Search AMPHIPHILIC+BETA+STRUCTURAL+PEPTIDE Search AMPHIPHILIC+BETA+STRUCTURAL+PEPTIDE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 YAMADA, K , KODAIRA, M , SHINODA, S , KOMAGOE, K , OKU, H , KATAKAI, R , KATSU, T , MATSUO, I , (2011) STRUCTURE-ACTIVITY RELATIONSHIPS OF GRAMICIDIN S ANALOGS CONTAINING (BETA-3-PYRIDYL)-ALPHA,BETA-DEHYDROALANINE RESIDUES ON MEMBRANE PERMEABILITY.MEDCHEMCOMM. VOL. 2. ISSUE 7. P. 644 -649 31 67% 3
2 KAPOERCHAN, VV , KNIJNENBURG, AD , KEIZER, P , SPALBURG, E , DE NEELING, AJ , MARS-GROENENDIJK, RH , NOORT, D , OTERO, JM , LLAMAS-SAIZ, AL , VAN RAAIJ, MJ , ET AL (2012) 'INVERTED' ANALOGS OF THE ANTIBIOTIC GRAMICIDIN S WITH AN IMPROVED BIOLOGICAL PROFILE.BIOORGANIC & MEDICINAL CHEMISTRY. VOL. 20. ISSUE 20. P. 6059 -6062 23 82% 1
3 SATO, K , YAMAGUCHI, Y , NAGAI, U , (2013) DESIGN AND SYNTHESIS OF GRAMICIDIN S ANALOGS WITH HIGH ANTIBIOTIC ACTIVITY.BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN. VOL. 86. ISSUE 1. P. 112 -120 19 95% 1
4 KAPOERCHAN, VV , KNIJNENBURG, AD , NIAMAT, M , SPALBURG, E , DE NEELING, AJ , NIBBERING, PH , MARS-GROENENDIJK, RH , NOORT, D , OTERO, JM , LLAMAS-SAIZ, AL , ET AL (2010) AN ADAMANTYL AMINO ACID CONTAINING GRAMICIDIN S ANALOGUE WITH BROAD SPECTRUM ANTIBACTERIAL ACTIVITY AND REDUCED HEMOLYTIC ACTIVITY.CHEMISTRY-A EUROPEAN JOURNAL. VOL. 16. ISSUE 40. P. 12174 -12181 30 63% 10
5 WADHWANI, P , AFONIN, S , IEROMINO, M , BUERCK, J , ULRICH, AS , (2006) OPTIMIZED PROTOCOL FOR SYNTHESIS OF CYCLIC GRAMICIDIN S: STARTING AMINO ACID IS KEY TO HIGH YIELD.JOURNAL OF ORGANIC CHEMISTRY. VOL. 71. ISSUE 1. P. 55 -61 37 52% 47
6 SOLANAS, C , DE LA TORRE, BG , FERNANDEZ-REYES, M , SANTIVERI, CM , JIMENEZ, MA , RIVAS, L , JIMENEZ, AI , ANDREU, D , CATIVIELA, C , (2009) THERAPEUTIC INDEX OF GRAMICIDIN S IS STRONGLY MODULATED BY D-PHENYLALANINE ANALOGUES AT THE BETA-TURN.JOURNAL OF MEDICINAL CHEMISTRY. VOL. 52. ISSUE 3. P. 664 -674 28 55% 26
7 VAN DER KNAAP, M , LAGEVEEN, LT , BUSSCHER, HJ , MARS-GROENENDIJK, R , NOORT, D , OTERO, JM , LLAMAS-SAIZ, AL , VAN RAAIJ, MJ , VAN DER MAREL, GA , OVERKLEEFT, HS , ET AL (2011) EVALUATION OF READILY ACCESSIBLE AZOLES AS MIMICS OF THE AROMATIC RING OF D-PHENYLALANINE IN THE TURN REGION OF GRAMICIDIN S.CHEMMEDCHEM. VOL. 6. ISSUE 5. P. 840 -847 23 66% 5
8 ABRAHAM, T , MARWAHA, S , KOBEWKA, DM , LEWIS, RNAH , PRENNER, EJ , HODGES, RS , MCELHANEY, RN , (2007) THE RELATIONSHIP BETWEEN THE BINDING TO AND PERMEABILIZATION OF PHOSPHOLIPID BILAYER MEMBRANES BY GS14DK(4), A DESIGNED ANALOG OF THE ANTIMICROBIAL PEPTIDE GRAMICIDIN S.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. VOL. 1768. ISSUE 9. P. 2089-2098 19 79% 14
9 ABRAHAM, T , PRENNER, EJ , LEWIS, RNAH , MANT, CT , KELLER, S , HODGES, RS , MCELHANEY, RN , (2014) STRUCTURE-ACTIVITY RELATIONSHIPS OF THE ANTIMICROBIAL PEPTIDE GRAMICIDIN S AND ITS ANALOGS: AQUEOUS SOLUBILITY, SELF-ASSOCIATION, CONFORMATION, ANTIMICROBIAL ACTIVITY AND INTERACTION WITH MODEL LIPID MEMBRANES.BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. VOL. 1838. ISSUE 5. P. 1420-1429 21 55% 4
10 KNIJNENBURG, AD , SPALBURG, E , DE NEELING, AJ , MARS-GROENENDIJK, RH , NOORT, D , GROTENBREG, GM , VAN DER MAREL, GA , OVERKLEEFT, HS , OVERHAND, M , (2012) RING-EXTENDED GRAMICIDIN S ANALOGS CONTAINING CIS D-SUGAR AMINO ACID TURN MIMETICS WITH VARYING RING SIZE.HELVETICA CHIMICA ACTA. VOL. 95. ISSUE 12. P. 2544 -2561 22 55% 2

Classes with closest relation at Level 1


Rank Class id link
1 29163 BIOLOGICAL BASED AGENT//ENZYMATIC TURNOVER NUMBER//ENZYME DIRECTED PEPTIDE SYNTHESIS MODEL
2 18790 SUGAR AMINO ACIDS//CARBOHYDRATE AMINO ACIDS//CARBOHYDRATE SCAFFOLDS
3 15801 DEHYDROPHENYLALANINE//DEHYDROAMINO ACIDS//ALPHA BETA DEHYDROAMINO ACIDS
4 210 ANTIMICROBIAL PEPTIDE//FROG SKIN//TEMPORIN
5 36772 PENCLOMEDINE//BOETIUS THERMOMICROSCOPY//THERMOTROP LIQUID CRYSTAL
6 16665 MELITTIN//MELITTEN//ALA 14MELITTIN
7 19202 VACCARIA SEGETALIS//CYCLOPEPTIDE//DIANTHUS SUPERBUS
8 19781 HELMINTHOSPORIUM CARBONUM//BIPOLARIS ZEICOLA//HC TOXIN
9 10577 ION-SELECTIVE ELECTRODE REVIEWS//DISSOLUTION RELEASE//INSITU S ALKYLISOTHIOURONIUM SALT GENERATION
10 6167 INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH//PHARMACEUT SCI SAKYO KU//MED SAKYO KU

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