Class information for:
Level 1: DYRK1A//DYRK2//MINIBRAIN

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
23594 341 44.9 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
196 3       GENETICS & HEREDITY//FRAGILE X SYNDROME//AMERICAN JOURNAL OF MEDICAL GENETICS 53756
2731 2             DOWN SYNDROME//DYRK1A//TS65DN 3262
23594 1                   DYRK1A//DYRK2//MINIBRAIN 341

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 DYRK1A authKW 4213571 23% 61% 77
2 DYRK2 authKW 756654 4% 65% 13
3 MINIBRAIN authKW 746212 3% 83% 10
4 DYRK authKW 601939 3% 61% 11
5 MIRK DYRK1B authKW 460520 2% 86% 6
6 DYRK1B authKW 365640 2% 58% 7
7 DYRK1 authKW 358184 1% 100% 4
8 UNIT FUNCT AD TAT BIOL BFA address 286545 1% 80% 4
9 LEUCETTINES authKW 268638 1% 100% 3
10 BRAIN SCI TECHNOL address 225713 3% 23% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 915 44% 0% 150
2 Chemistry, Medicinal 621 13% 0% 45
3 Cell Biology 364 18% 0% 62
4 Neurosciences 180 16% 0% 53
5 Genetics & Heredity 149 10% 0% 34
6 Biophysics 84 7% 0% 23
7 Oncology 52 9% 0% 29
8 Developmental Biology 43 3% 0% 9
9 Integrative & Complementary Medicine 13 1% 0% 3
10 Chemistry, Organic 12 4% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 UNIT FUNCT AD TAT BIOL BFA 286545 1% 80% 4
2 BRAIN SCI TECHNOL 225713 3% 23% 11
3 LCBSN 179092 1% 100% 2
4 PROT PHOSPHORYLAT HUMAN DIS GRP 165809 3% 19% 10
5 GRP INGN CHIM MOL VIVANT ICMV 139909 1% 31% 5
6 CHIM BIOORGAN SUBST NAT LCBOSN 119393 1% 67% 2
7 GRP ICMV 119393 1% 67% 2
8 IMPACCELL PLATFORM 119393 1% 67% 2
9 PERHARIDY 95374 2% 15% 7
10 ALTA TECNOL IAT CRC CORP SANITARIA 89546 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 NEUROBIOLOGY OF DISEASE 1555 2% 0% 8
2 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 948 3% 0% 10
3 FEBS JOURNAL 591 2% 0% 6
4 JOURNAL OF BIOLOGICAL CHEMISTRY 530 9% 0% 31
5 JOURNAL OF NEURAL TRANSMISSION-SUPPLEMENT 449 1% 0% 2
6 MEDICINAL CHEMISTRY RESEARCH 444 1% 0% 4
7 BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 414 3% 0% 11
8 ACS CHEMICAL NEUROSCIENCE 390 1% 0% 2
9 NEUROSIGNALS 312 0% 0% 1
10 EUROPEAN JOURNAL OF MEDICAL GENETICS 311 1% 0% 2

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 DYRK1A 4213571 23% 61% 77 Search DYRK1A Search DYRK1A
2 DYRK2 756654 4% 65% 13 Search DYRK2 Search DYRK2
3 MINIBRAIN 746212 3% 83% 10 Search MINIBRAIN Search MINIBRAIN
4 DYRK 601939 3% 61% 11 Search DYRK Search DYRK
5 MIRK DYRK1B 460520 2% 86% 6 Search MIRK+DYRK1B Search MIRK+DYRK1B
6 DYRK1B 365640 2% 58% 7 Search DYRK1B Search DYRK1B
7 DYRK1 358184 1% 100% 4 Search DYRK1 Search DYRK1
8 LEUCETTINES 268638 1% 100% 3 Search LEUCETTINES Search LEUCETTINES
9 WDR68 201477 1% 75% 3 Search WDR68 Search WDR68
10 5 ARYLIDENE RHODANINE 179092 1% 100% 2 Search 5+ARYLIDENE+RHODANINE Search 5+ARYLIDENE+RHODANINE

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 TEJEDOR, FJ , HAMMERLE, B , (2011) MNB/DYRK1A AS A MULTIPLE REGULATOR OF NEURONAL DEVELOPMENT.FEBS JOURNAL. VOL. 278. ISSUE 2. P. 223 -235 62 68% 63
2 DUCHON, A , HERAULT, Y , (2016) DYRK1A, A DOSAGE-SENSITIVE GENE INVOLVED IN NEURODEVELOPMENTAL DISORDERS, IS A TARGET FOR DRUG DEVELOPMENT IN DOWN SYNDROME.FRONTIERS IN BEHAVIORAL NEUROSCIENCE. VOL. 10. ISSUE . P. - 98 46% 0
3 ARANDA, S , LAGUNA, A , DE LA LUNA, S , (2011) DYRK FAMILY OF PROTEIN KINASES: EVOLUTIONARY RELATIONSHIPS, BIOCHEMICAL PROPERTIES, AND FUNCTIONAL ROLES.FASEB JOURNAL. VOL. 25. ISSUE 2. P. 449 -462 61 62% 89
4 ABBASSI, R , JOHNS, TG , KASSIOU, M , MUNOZ, L , (2015) DYRK1A IN NEURODEGENERATION AND CANCER: MOLECULAR BASIS AND CLINICAL IMPLICATIONS.PHARMACOLOGY & THERAPEUTICS. VOL. 151. ISSUE . P. 87 -98 57 57% 12
5 BECKER, W , SOPPA, U , TEJEDOR, FJ , (2014) DYRK1A: A POTENTIAL DRUG TARGET FOR MULTIPLE DOWN SYNDROME NEUROPATHOLOGIES.CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS. VOL. 13. ISSUE 1. P. 26-33 56 58% 22
6 DIERSSEN, M , DE LAGRAN, MM , (2006) DYRK1A (DUAL-SPECIFICITY TYROSINE-PHOSPHORYLATED AND -REGULATED KINASE 1A): A GENE WITH DOSAGE EFFECT DURING DEVELOPMENT AND NEUROGENESIS.THESCIENTIFICWORLDJOURNAL. VOL. 6. ISSUE . P. 1911-1922 45 80% 49
7 YOSHIDA, K , (2008) ROLE FOR DYRK FAMILY KINASES ON REGULATION OF APOPTOSIS.BIOCHEMICAL PHARMACOLOGY. VOL. 76. ISSUE 11. P. 1389 -1394 41 76% 33
8 SOUNDARARAJAN, M , ROOS, AK , SAVITSKY, P , FILIPPAKOPOULOS, P , KETTENBACH, AN , OLSEN, JV , GERBER, SA , ESWARAN, J , KNAPP, S , ELKINS, JM , (2013) STRUCTURES OF DOWN SYNDROME KINASES, DYRKS, REVEAL MECHANISMS OF KINASE ACTIVATION AND SUBSTRATE RECOGNITION.STRUCTURE. VOL. 21. ISSUE 6. P. 986-996 39 66% 23
9 SCHMITT, C , KAIL, D , MARIANO, M , EMPTING, M , WEBER, N , PAUL, T , HARTMANN, RW , ENGEL, M , (2014) DESIGN AND SYNTHESIS OF A LIBRARY OF LEAD-LIKE 2,4-BISHETEROCYCLIC SUBSTITUTED THIOPHENES AS SELECTIVE DYRK/CLK INHIBITORS.PLOS ONE. VOL. 9. ISSUE 3. P. - 48 49% 12
10 CHUNG, KC , PARK, J , SONG, WJ , (2009) FUNCTION AND REGULATION OF DYRK1A: TOWARDS UNDERSTANDING DOWN SYNDROME.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 66. ISSUE 20. P. 3235 -3240 39 62% 79

Classes with closest relation at Level 1


Rank Class id link
1 3268 DOWN SYNDROME//TS65DN//TS65DN MICE
2 25325 MICROWAVE ASSISTED CHEMISTRY//GRP CHIM ORGAN//IMINO 1 2 3 DITHIAZOLES
3 23684 HIPK2//SIAH2//SIAH1
4 20700 MERIDIANINS//APLYSINOPSIN//NORTOPSENTIN
5 31511 RANBPM//RANBP9//IMMUNEREGULAT
6 23744 SPROUTY//SPROUTY2//SPRED
7 36779 CDK11P58//PITSLRE//CDK11
8 19181 NRSF//REST NRSF//NRSF REST
9 8632 BETA CARBOLINE//HARMINE//NORHARMAN
10 12551 CALCINEURIN//RCAN1//DSCR1

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