Class information for:
Level 1: TRKA//TRKB//P75NTR

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
18168 563 41.5 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
268 3       NEUROTROPHINS//BRAIN DERIVED NEUROTROPHIC FACTOR//BDNF 44049
879 2             NEUROTROPHINS//BRAIN DERIVED NEUROTROPHIC FACTOR//BDNF 11456
18168 1                   TRKA//TRKB//P75NTR 563

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TRKA authKW 325402 10% 10% 59
2 TRKB authKW 284309 11% 8% 62
3 P75NTR authKW 207528 7% 10% 40
4 AZ64 authKW 162707 1% 100% 3
5 TROPOMYOSIN RECEPTOR KINASES authKW 162707 1% 100% 3
6 TRK INHIBITOR authKW 108471 0% 100% 2
7 TRK INHIBITORS authKW 108471 0% 100% 2
8 TRKA INHIBITOR authKW 108471 0% 100% 2
9 TRKA KINASE authKW 108471 0% 100% 2
10 TRKB NTRK2 authKW 108471 0% 100% 2

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Oncology 5022 49% 0% 275
2 Cell Biology 815 21% 0% 117
3 Biochemistry & Molecular Biology 272 22% 0% 123
4 Pathology 219 6% 0% 35
5 Chemistry, Medicinal 105 5% 0% 27
6 Genetics & Heredity 75 6% 0% 35
7 Medicine, Research & Experimental 38 4% 0% 24
8 Endocrinology & Metabolism 33 4% 0% 24
9 CYTOLOGY & HISTOLOGY 25 0% 0% 2
10 Hematology 20 3% 0% 15

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 U GROWTH TOR SIGNALING BREAST CANC CELLS FUNCT 108471 0% 100% 2
2 VINCENT T LOMBARDI COMPREHENS CANC 96843 1% 36% 5
3 MOL DIS CELL REGULAT 78883 1% 36% 4
4 CELL MOL BIOL SECT 78106 2% 13% 11
5 CANC NEUROBIOL 69728 1% 43% 3
6 CLIN HOSP CPE HCPA 69728 1% 43% 3
7 ABRAHAMSON 916 54236 0% 100% 1
8 AFFILIATED PLA CLIN 54236 0% 100% 1
9 AFLAC CANC BLOOD SERV 54236 0% 100% 1
10 ALLIED HLTH PROFESS MIDWIFEIY 54236 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ONCOGENE 1846 4% 0% 25
2 GROWTH FACTORS 1698 1% 1% 5
3 CLINICAL CANCER RESEARCH 1159 3% 0% 18
4 CELL GROWTH & DIFFERENTIATION 954 1% 0% 5
5 ONCOLOGY REPORTS 905 2% 0% 13
6 CANCER RESEARCH 641 4% 0% 22
7 PROSTATE 573 1% 0% 7
8 CANCER MEDICINE 543 1% 0% 3
9 BIOSCIENCE TRENDS 466 0% 0% 2
10 CANCER LETTERS 432 2% 0% 10

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TRKA 325402 10% 10% 59 Search TRKA Search TRKA
2 TRKB 284309 11% 8% 62 Search TRKB Search TRKB
3 P75NTR 207528 7% 10% 40 Search P75NTR Search P75NTR
4 AZ64 162707 1% 100% 3 Search AZ64 Search AZ64
5 TROPOMYOSIN RECEPTOR KINASES 162707 1% 100% 3 Search TROPOMYOSIN+RECEPTOR+KINASES Search TROPOMYOSIN+RECEPTOR+KINASES
6 TRK INHIBITOR 108471 0% 100% 2 Search TRK+INHIBITOR Search TRK+INHIBITOR
7 TRK INHIBITORS 108471 0% 100% 2 Search TRK+INHIBITORS Search TRK+INHIBITORS
8 TRKA INHIBITOR 108471 0% 100% 2 Search TRKA+INHIBITOR Search TRKA+INHIBITOR
9 TRKA KINASE 108471 0% 100% 2 Search TRKA+KINASE Search TRKA+KINASE
10 TRKB NTRK2 108471 0% 100% 2 Search TRKB+NTRK2 Search TRKB+NTRK2

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 AKIL, H , PERRAUD, A , JAUBERTEAU, MO , MATHONNET, M , (2016) TROPOMYOSIN-RELATED KINASE B/BRAIN DERIVED-NEUROTROPHIC FACTOR SIGNALING PATHWAY AS A POTENTIAL THERAPEUTIC TARGET FOR COLORECTAL CANCER.WORLD JOURNAL OF GASTROENTEROLOGY. VOL. 22. ISSUE 2. P. 490 -500 60 51% 1
2 CROUCHER, JL , IYER, R , LI, NX , MOLTENI, V , LOREN, J , GORDON, WP , TUNTLAND, T , LIU, B , BRODEUR, GM , (2015) TRKB INHIBITION BY GNF-4256 SLOWS GROWTH AND ENHANCES CHEMOTHERAPEUTIC EFFICACY IN NEUROBLASTOMA XENOGRAFTS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 75. ISSUE 1. P. 131 -141 46 67% 3
3 IYER, R , WEHRMANN, L , GOLDEN, RL , NARAPARAJU, K , CROUCHER, JL , MACFARLAND, SP , GUAN, P , KOLLA, V , WEI, G , CAM, N , ET AL (2016) ENTRECTINIB IS A POTENT INHIBITOR OF TRK-DRIVEN NEUROBLASTOMAS IN A XENOGRAFT MOUSE MODEL.CANCER LETTERS. VOL. 372. ISSUE 2. P. 179 -186 45 55% 1
4 DEMIR, IE , TIEFTRUNK, E , SCHORN, S , FRIESS, H , CEYHAN, GO , (2016) NERVE GROWTH FACTOR & TRKA AS NOVEL THERAPEUTIC TARGETS IN CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1866. ISSUE 1. P. 37 -50 60 41% 1
5 CHOPIN, V , LAGADEC, C , TOILLON, RA , LE BOURHIS, X , (2016) NEUROTROPHIN SIGNALING IN CANCER STEM CELLS.CELLULAR AND MOLECULAR LIFE SCIENCES. VOL. 73. ISSUE 9. P. 1859 -1870 52 43% 2
6 VANHECKE, E , ADRIAENSSENS, E , VERBEKE, S , MEIGNAN, S , GERMAIN, E , BERTEAUX, N , NURCOMBE, V , LE BOURHIS, X , HONDERMARCK, H , (2011) BRAIN-DERIVED NEUROTROPHIC FACTOR AND NEUROTROPHIN-4/5 ARE EXPRESSED IN BREAST CANCER AND CAN BE TARGETED TO INHIBIT TUMOR CELL SURVIVAL.CLINICAL CANCER RESEARCH. VOL. 17. ISSUE 7. P. 1741-1752 30 70% 35
7 THIELE, CJ , LI, ZJ , MCKEE, AE , (2009) ON TRK-THE TRKB SIGNAL TRANSDUCTION PATHWAY IS AN INCREASINGLY IMPORTANT TARGET IN CANCER BIOLOGY.CLINICAL CANCER RESEARCH. VOL. 15. ISSUE 19. P. 5962-5967 38 51% 96
8 LI, L , ZHU, L , (2017) EXPRESSION AND CLINICAL SIGNIFICANCE OF TRKB IN SINONASAL SQUAMOUS CELL CARCINOMA: A PILOT STUDY.INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. VOL. 46. ISSUE 2. P. 144 -150 23 79% 0
9 HUA, ZY , GU, X , DONG, YD , TAN, F , LIU, ZH , THIELE, CJ , LI, ZJ , (2016) PI3K AND MAPK PATHWAYS MEDIATE THE BDNF/TRKB-INCREASED METASTASIS IN NEUROBLASTOMA.TUMOR BIOLOGY. VOL. 37. ISSUE 12. P. 16227 -16236 28 65% 0
10 IYER, R , VARELA, CR , MINTURN, JE , HO, R , SIMPSON, AM , LIGHT, JE , EVANS, AE , ZHAO, HQ , THRESS, K , BROWN, JL , ET AL (2012) AZ64 INHIBITS TRKB AND ENHANCES THE EFFICACY OF CHEMOTHERAPY AND LOCAL RADIATION IN NEUROBLASTOMA XENOGRAFTS.CANCER CHEMOTHERAPY AND PHARMACOLOGY. VOL. 70. ISSUE 3. P. 477-486 35 54% 6

Classes with closest relation at Level 1


Rank Class id link
1 8929 P75NTR//P75 NEUROTROPHIN RECEPTOR//PRONGF
2 28143 BHARATI MED HOSP//ATTAPPADY BLACK//ENDOCRINOL BIOL REPROD
3 10818 NERVE GROWTH FACTOR//NEUROTROPHINS//NGF
4 25796 ANOIKIS//MED ENGN AFEKA//BIOL CELLULAIRE EXPT
5 744 NERVE GROWTH FACTOR//NEUROTROPHINS//NEUROTROPHIN 3
6 21256 TANEZUMAB//FULRANUMAB//NERVE GROWTH FACTOR
7 23905 PERINEURAL SPREAD//QUEENSLAND SKULL BASE UNIT//JUXTAORAL ORGAN
8 598 NEUROBLASTOMA//MYCN//MYCN AMPLIFICATION
9 17092 RUFFLE//PROTEIN KINASE N//GROWTH TORS SECT NIH
10 36911 BEX2//LDOC1 GENE//LDOC1

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