Class information for:
Level 1: PTPN22//PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 22//PTPN22 GENE

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
15666 699 40.7 93%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
297 3       DIABETES//ISLET TRANSPLANTATION//BETA CELL 41297
789 2             TYPE 1 DIABETES//BARBARA DAVIS CHILDHOOD DIABET//PTPN22 12133
15666 1                   PTPN22//PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 22//PTPN22 GENE 699

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 PTPN22 authKW 3628321 17% 72% 116
2 PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 22 authKW 614291 2% 94% 15
3 PTPN22 GENE authKW 517293 2% 79% 15
4 LYP authKW 385601 2% 55% 16
5 STAT4 authKW 314472 4% 24% 30
6 PROTEIN TYROSINE PHOSPHATASE NON RECEPTOR TYPE 22 authKW 237827 1% 78% 7
7 STAT4 GENE authKW 224654 1% 86% 6
8 IL2RA authKW 153829 1% 39% 9
9 PTPN22 GENE POLYMORPHISM authKW 131049 0% 100% 3
10 TRAF1 C5 authKW 116485 1% 67% 4

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Rheumatology 11573 23% 0% 164
2 Immunology 3469 34% 0% 240
3 Genetics & Heredity 1482 20% 0% 140
4 Endocrinology & Metabolism 413 10% 0% 73
5 Pathology 123 4% 0% 31
6 Cell Biology 69 7% 0% 50
7 Medicine, Research & Experimental 53 4% 0% 31
8 Biochemistry & Molecular Biology 42 11% 0% 79
9 Allergy 28 1% 0% 8
10 Gastroenterology & Hepatology 8 2% 0% 13

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ADDENBROOKES HOSPJUVENILE DIABET FDN 87366 0% 100% 2
2 ANCHORAGE ARTS SCI 87366 0% 100% 2
3 U958 87366 0% 100% 2
4 WELLCOME TRUST DIABET INFLAMMAT 78603 2% 12% 15
5 GENES ENVIRONM COMPLEX DIS 65522 0% 50% 3
6 U730 65516 1% 25% 6
7 MOL MED HUMAN GENET 62894 1% 24% 6
8 ADDENBROOKES HOSP MED GENET 58243 0% 67% 2
9 CONSULTAT GENET ADULTE 58243 0% 67% 2
10 JUVENILE DIABET FDNCAMBRIDGE MED 58239 1% 33% 4

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GENES AND IMMUNITY 42735 5% 3% 37
2 HUMAN IMMUNOLOGY 4963 3% 0% 23
3 ARTHRITIS AND RHEUMATISM 4601 5% 0% 33
4 TISSUE ANTIGENS 4291 3% 0% 21
5 ARTHRITIS RESEARCH & THERAPY 3846 2% 1% 17
6 INTERNATIONAL JOURNAL OF IMMUNOGENETICS 3336 1% 1% 8
7 RHEUMATOLOGY 2670 2% 0% 17
8 ANNALS OF THE RHEUMATIC DISEASES 2570 3% 0% 23
9 CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY 1819 1% 1% 5
10 NATURE GENETICS 1472 2% 0% 13

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 PTPN22 3628321 17% 72% 116 Search PTPN22 Search PTPN22
2 PROTEIN TYROSINE PHOSPHATASE NONRECEPTOR 22 614291 2% 94% 15 Search PROTEIN+TYROSINE+PHOSPHATASE+NONRECEPTOR+22 Search PROTEIN+TYROSINE+PHOSPHATASE+NONRECEPTOR+22
3 PTPN22 GENE 517293 2% 79% 15 Search PTPN22+GENE Search PTPN22+GENE
4 LYP 385601 2% 55% 16 Search LYP Search LYP
5 STAT4 314472 4% 24% 30 Search STAT4 Search STAT4
6 PROTEIN TYROSINE PHOSPHATASE NON RECEPTOR TYPE 22 237827 1% 78% 7 Search PROTEIN+TYROSINE+PHOSPHATASE+NON+RECEPTOR+TYPE+22 Search PROTEIN+TYROSINE+PHOSPHATASE+NON+RECEPTOR+TYPE+22
7 STAT4 GENE 224654 1% 86% 6 Search STAT4+GENE Search STAT4+GENE
8 IL2RA 153829 1% 39% 9 Search IL2RA Search IL2RA
9 PTPN22 GENE POLYMORPHISM 131049 0% 100% 3 Search PTPN22+GENE+POLYMORPHISM Search PTPN22+GENE+POLYMORPHISM
10 TRAF1 C5 116485 1% 67% 4 Search TRAF1+C5 Search TRAF1+C5

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 ZHENG, J , IBRAHIM, S , PETERSEN, F , YU, X , (2012) META-ANALYSIS REVEALS AN ASSOCIATION OF PTPN22 C1858T WITH AUTOIMMUNE DISEASES, WHICH DEPENDS ON THE LOCALIZATION OF THE AFFECTED TISSUE.GENES AND IMMUNITY. VOL. 13. ISSUE 8. P. 641-652 96 77% 25
2 STANFORD, SM , BOTTINI, N , (2014) PTPN22: THE ARCHETYPAL NON-HLA AUTOIMMUNITY GENE.NATURE REVIEWS RHEUMATOLOGY. VOL. 10. ISSUE 10. P. 602 -611 78 70% 39
3 BOTTINI, N , PETERSON, EJ , (2014) TYROSINE PHOSPHATASE PTPN22: MULTIFUNCTIONAL REGULATOR OF IMMUNE SIGNALING, DEVELOPMENT, AND DISEASE.ANNUAL REVIEW OF IMMUNOLOGY, VOL 32. VOL. 32. ISSUE . P. 83 -119 96 57% 32
4 ELSHAZLI, R , SETTIN, A , (2015) ASSOCIATION OF PTPN22 RS2476601 AND STAT4 RS7574865 POLYMORPHISMS WITH RHEUMATOID ARTHRITIS: A META-ANALYSIS UPDATE.IMMUNOBIOLOGY. VOL. 220. ISSUE 8. P. 1012 -1024 67 79% 7
5 DU, JT , QIAO, Y , SUN, LL , WANG, XW , (2014) LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP): A POTENTIAL DRUG TARGET FOR TREATMENT OF AUTOIMMUNE DISEASES.CURRENT DRUG TARGETS. VOL. 15. ISSUE 3. P. 335-346 69 78% 0
6 STANFORD, SM , MUSTELIN, TM , BOTTINI, N , (2010) LYMPHOID TYROSINE PHOSPHATASE AND AUTOIMMUNITY: HUMAN GENETICS REDISCOVERS TYROSINE PHOSPHATASES.SEMINARS IN IMMUNOPATHOLOGY. VOL. 32. ISSUE 2. P. 127 -136 77 63% 23
7 RAWLINGS, DJ , DAI, XZ , BUCKNER, JH , (2015) THE ROLE OF PTPN22 RISK VARIANT IN THE DEVELOPMENT OF AUTOIMMUNITY: FINDING COMMON GROUND BETWEEN MOUSE AND HUMAN.JOURNAL OF IMMUNOLOGY. VOL. 194. ISSUE 7. P. 2977 -2984 34 89% 12
8 BURN, GL , SVENSSON, L , SANCHEZ-BLANCO, C , SAINI, M , COPE, AP , (2011) WHY IS PTPN22 A GOOD CANDIDATE SUSCEPTIBILITY GENE FOR AUTOIMMUNE DISEASE?.FEBS LETTERS. VOL. 585. ISSUE 23. P. 3689-3698 54 59% 69
9 GIZA, S , GOULAS, A , GBANDI, E , EFFRAIMIDOU, S , PAPADOPOULOU-ALATAKI, E , EBORIADOU, M , GALLI-TSINOPOULOU, A , (2013) THE ROLE OF PTPN22 C1858T GENE POLYMORPHISM IN DIABETES MELLITUS TYPE 1: FIRST EVALUATION IN GREEK CHILDREN AND ADOLESCENTS.BIOMED RESEARCH INTERNATIONAL. VOL. . ISSUE . P. - 38 90% 6
10 LEE, YH , RHO, YH , CHOI, SJ , JI, JD , SONG, GG , NATH, SK , HARLEY, JB , (2007) THE PTPN22 C1858T FUNCTIONAL POLYMORPHISM AND AUTOIMMUNE DISEASES - A META-ANALYSIS.RHEUMATOLOGY. VOL. 46. ISSUE 1. P. 49-56 36 80% 214

Classes with closest relation at Level 1


Rank Class id link
1 10461 IRF5//GENOM INVEST ONCOL GENYO//INTERFERON REGULATORY FACTOR 5
2 32315 FCRL3//FCRL//FCRL3 GENE
3 8234 CTLA 4//CTLA 4 GENE//GRAVES DISEASE
4 2095 CITRULLINATION//PEPTIDYLARGININE DEIMINASE//RHEUMATOID FACTOR
5 19765 A20//RNF11//ZINC FINGER PROTEIN A20
6 6177 IDDM2//INS VNTR//INSULIN GENE
7 11806 SHARED EPITOPE//HLA DRB1//RHEUMATOID ARTHRITIS
8 12217 LYMPHOTOXIN ALPHA//GALECTIN 2//TNF MICROSATELLITE
9 8190 MULTIPLE SCLEROSIS//FAMILIAL MULTIPLE SCLEROSIS//PROGRAM NEUROPSYCHIAT GENOM
10 5671 CROHNS DISEASE//CARD15//ATG16L1

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