Class information for:
Level 1: TIAGABINE//GABA TRANSPORTER//GABA UPTAKE INHIBITORS

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
14888 744 36.6 65%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
11 4 NEUROSCIENCES//CLINICAL NEUROLOGY//NEUROL 1112395
305 3       NICOTINIC ACETYLCHOLINE RECEPTOR//BENZODIAZEPINES//NICOTINIC RECEPTORS 40571
739 2             GABAA RECEPTOR//GABAB RECEPTOR//GABA 12562
14888 1                   TIAGABINE//GABA TRANSPORTER//GABA UPTAKE INHIBITORS 744

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 TIAGABINE authKW 3253954 20% 53% 149
2 GABA TRANSPORTER authKW 920206 8% 36% 63
3 GABA UPTAKE INHIBITORS authKW 804088 3% 85% 23
4 GABA UPTAKE authKW 726159 6% 43% 41
5 GABA UPTAKE INHIBITOR authKW 473171 2% 82% 14
6 GAT 1 authKW 277003 2% 38% 18
7 NIPECOTIC ACID authKW 246221 2% 33% 18
8 GAT1 authKW 187051 2% 33% 14
9 EF1502 authKW 164163 1% 100% 4
10 GAMMA AMINOBUTYRIC ACID TRANSPORTER authKW 147742 1% 60% 6

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Neurosciences 3113 38% 0% 285
2 Chemistry, Medicinal 1828 15% 0% 113
3 Clinical Neurology 1124 18% 0% 134
4 Pharmacology & Pharmacy 1029 23% 0% 174
5 Biochemistry & Molecular Biology 88 14% 0% 101
6 Chemistry, Organic 84 6% 0% 48
7 Psychiatry 24 3% 0% 24
8 Chemistry, Multidisciplinary 19 7% 0% 49
9 Developmental Biology 12 1% 0% 9
10 Anatomy & Morphology 9 1% 0% 5

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ZENTRUM PHARMAFOR 103343 3% 11% 23
2 FDN MOL MED 82082 0% 100% 2
3 ANTICONVULSANT DRUG DEV PROGRAM 81577 2% 15% 13
4 PHYSICOCHEM DRUG ANAL 77043 2% 14% 13
5 SECT HISTOL HUMAN ANAT 72957 1% 44% 4
6 ADEN EA 41041 0% 100% 1
7 BIOCHEM CELL BIOLMED ORGANISM 41041 0% 100% 1
8 BIOCHEM MED CHEM MOL BIOCHEM 41041 0% 100% 1
9 COMPARAT PSYCHOPHYSIOL GRP 41041 0% 100% 1
10 COMPREHENS EPILEPSY MANGEMENT 41041 0% 100% 1

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 REVIEWS IN CONTEMPORARY PHARMACOTHERAPY 7370 1% 4% 4
2 EPILEPSY RESEARCH 7136 3% 1% 26
3 EPILEPSIA 6268 5% 0% 37
4 SEIZURE-EUROPEAN JOURNAL OF EPILEPSY 2415 2% 0% 12
5 JOURNAL OF NEUROSCIENCE RESEARCH 1845 3% 0% 20
6 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 1563 3% 0% 19
7 CHEMMEDCHEM 1436 1% 0% 9
8 NEUROCHEMICAL RESEARCH 1419 2% 0% 16
9 DRUG DEVELOPMENT RESEARCH 1377 1% 0% 10
10 NEUROCHEMISTRY INTERNATIONAL 1091 2% 0% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 TIAGABINE 3253954 20% 53% 149 Search TIAGABINE Search TIAGABINE
2 GABA TRANSPORTER 920206 8% 36% 63 Search GABA+TRANSPORTER Search GABA+TRANSPORTER
3 GABA UPTAKE INHIBITORS 804088 3% 85% 23 Search GABA+UPTAKE+INHIBITORS Search GABA+UPTAKE+INHIBITORS
4 GABA UPTAKE 726159 6% 43% 41 Search GABA+UPTAKE Search GABA+UPTAKE
5 GABA UPTAKE INHIBITOR 473171 2% 82% 14 Search GABA+UPTAKE+INHIBITOR Search GABA+UPTAKE+INHIBITOR
6 GAT 1 277003 2% 38% 18 Search GAT+1 Search GAT+1
7 NIPECOTIC ACID 246221 2% 33% 18 Search NIPECOTIC+ACID Search NIPECOTIC+ACID
8 GAT1 187051 2% 33% 14 Search GAT1 Search GAT1
9 EF1502 164163 1% 100% 4 Search EF1502 Search EF1502
10 GAMMA AMINOBUTYRIC ACID TRANSPORTER 147742 1% 60% 6 Search GAMMA+AMINOBUTYRIC+ACID+TRANSPORTER Search GAMMA+AMINOBUTYRIC+ACID+TRANSPORTER

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref.
in cl.		 Shr. of ref. in
cl.		 Citations
1 HOG, S , GREENWOOD, JR , MADSEN, KB , LARSSON, OM , FROLUND, B , SCHOUSBOE, A , KROGSGAARD-LARSEN, P , CLAUSEN, RP , (2006) STRUCTURE-ACTIVITY RELATIONSHIPS OF SELECTIVE GABA UPTAKE INHIBITORS.CURRENT TOPICS IN MEDICINAL CHEMISTRY. VOL. 6. ISSUE 17. P. 1861-1882 42 86% 34
2 MADSEN, KK , WHITE, HS , SCHOUSBOE, A , (2010) NEURONAL AND NON-NEURONAL GABA TRANSPORTERS AS TARGETS FOR ANTIEPILEPTIC DRUGS.PHARMACOLOGY & THERAPEUTICS. VOL. 125. ISSUE 3. P. 394-401 44 63% 75
3 KROGSGAARD-LARSEN, P , FROLUND, B , FRYDENVANG, K , (2000) GABA UPTAKE INHIBITORS. DESIGN, MOLECULAR PHARMACOLOGY AND THERAPEUTIC ASPECTS.CURRENT PHARMACEUTICAL DESIGN. VOL. 6. ISSUE 12. P. 1193 -1209 49 75% 56
4 KOWALCZYK, P , SALAT, K , HOFNER, GC , MUCHA, M , RAPACZ, A , PODKOWA, A , FILIPEK, B , WANNER, KT , KULIG, K , (2014) SYNTHESIS, BIOLOGICAL EVALUATION AND STRUCTURE-ACTIVITY RELATIONSHIP OF NEW GABA UPTAKE INHIBITORS, DERIVATIVES OF 4-AMINOBUTANAMIDES.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. VOL. 83. ISSUE . P. 256 -273 36 73% 0
5 DALBY, NO , (2003) INHIBITION OF GAMMA-AMINOBUTYRIC ACID UPTAKE: ANATOMY, PHYSIOLOGY AND EFFECTS AGAINST EPILEPTIC SEIZURES.EUROPEAN JOURNAL OF PHARMACOLOGY. VOL. 479. ISSUE 1-3. P. 127-137 61 49% 111
6 SALAT, K , KULIG, K , (2011) GABA TRANSPORTERS AS TARGETS FOR NEW DRUGS.FUTURE MEDICINAL CHEMISTRY. VOL. 3. ISSUE 2. P. 211-222 36 60% 10
7 SCHOUSBOE, A , MADSEN, KK , BARKER-HALISKI, ML , WHITE, HS , (2014) THE GABA SYNAPSE AS A TARGET FOR ANTIEPILEPTIC DRUGS: A HISTORICAL OVERVIEW FOCUSED ON GABA TRANSPORTERS.NEUROCHEMICAL RESEARCH. VOL. 39. ISSUE 10. P. 1980 -1987 30 63% 11
8 SCHOUSBOE, A , LARSSON, OM , SARUP, A , WHITE, HS , (2004) ROLE OF THE BETAINE/GABA TRANSPORTER (BGT1/GAT2) FOR THE CONTROL OF EPILEPSY.EUROPEAN JOURNAL OF PHARMACOLOGY. VOL. 500. ISSUE 1-3. P. 281-287 35 73% 19
9 MELDRUM, BS , CHAPMAN, AG , (1999) BASIC MECHANISMS OF GABITRIL (TIAGABINE) AND FUTURE POTENTIAL DEVELOPMENTS.EPILEPSIA. VOL. 40. ISSUE . P. S2-S6 39 74% 43
10 BUTTERY, PC , SISODIYA, SM , (2002) THE SAFETY, TOLERABILITY AND ADVERSE EVENTS PROFILE OF TIAGABINE.REVIEWS IN CONTEMPORARY PHARMACOTHERAPY. VOL. 12. ISSUE 5. P. 251-264 38 72% 2

Classes with closest relation at Level 1


Rank Class id link
1 4859 NEUROTRANSMITTER TRANSPORTER//NOREPINEPHRINE TRANSPORTER//DOPAMINE TRANSPORTER
2 26122 N BENZYLOXYCARBONYLGLYCINE//1 3 DIACYLAMINOPROPAN 2 OLS//1 3 DIACYLAMINO 2 O ACYL PROPANES
3 23445 GABAC RECEPTOR//GABAC//TPMPA
4 31896 ANTISECRETORY FACTOR//DEITERS NEURON//SPECIALLY PROCESSED CEREALS
5 15080 VIGABATRIN//GAMMA VINYL GABA//VISUAL FIELD CONSTRICTION
6 3055 LAMOTRIGINE//FELBAMATE//OXCARBAZEPINE
7 24511 TAIL FLICK INHIBITION//DIPARTIMENTO SCI FARMACOBIOL COMPLESSO NINI BARBI//DIALKYLAMINOALKYLNAPHTHALENES
8 5603 GABAB RECEPTOR//BACLOFEN//GABAB
9 20863 GLUTAMIC ACID DECARBOXYLASE//GLUTAMATE DECARBOXYLASE//GABA SYNTHESIS
10 806 GABAA RECEPTOR//TONIC INHIBITION//SECT BIOCHEM PSYCHIAT

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