Class information for:
Level 1: MIDKINE//PLEIOTROPHIN//HB GAM

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
13215 853 41.4 91%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
6 4 GASTROENTEROLOGY & HEPATOLOGY//ONCOLOGY//SURGERY 1371034
216 3       NON SMALL CELL LUNG CANCER//LUNG CANCER//THORAC SURG 51214
1717 2             GEFITINIB//EGFR MUTATION//MIDKINE 6648
13215 1                   MIDKINE//PLEIOTROPHIN//HB GAM 853

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MIDKINE authKW 8600078 33% 85% 282
2 PLEIOTROPHIN authKW 4708195 19% 81% 163
3 HB GAM authKW 492617 2% 81% 17
4 HEPARIN BINDING GROWTH ASSOCIATED MOLECULE authKW 303207 1% 71% 12
5 HEPARIN AFFIN REGULATORY PEPTIDE authKW 289947 1% 90% 9
6 TRUNCATED MIDKINE authKW 254549 1% 89% 8
7 HUMAN MIDKINE authKW 250573 1% 100% 7
8 MOL EXPT MED CELL BIOL address 250573 1% 100% 7
9 RECH CROISSANCE CELLULAIRE REPARAT REGENERA address 241602 2% 38% 18
10 MIDKINE MK authKW 229092 1% 80% 8

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Biochemistry & Molecular Biology 1154 33% 0% 280
2 Oncology 929 19% 0% 159
3 Cell Biology 626 15% 0% 132
4 Biophysics 385 9% 0% 74
5 Developmental Biology 316 4% 0% 36
6 Neurosciences 315 13% 0% 115
7 Pathology 71 3% 0% 28
8 Gastroenterology & Hepatology 57 3% 0% 28
9 Endocrinology & Metabolism 53 4% 0% 37
10 Medicine, Research & Experimental 47 4% 0% 34

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 MOL EXPT MED CELL BIOL 250573 1% 100% 7
2 RECH CROISSANCE CELLULAIRE REPARAT REGENERA 241602 2% 38% 18
3 PSYCHOL PHYS SCI 216015 3% 23% 26
4 HUZHOU MOL MED 167030 2% 33% 14
5 MEIJI CELL TECHNOL 152595 1% 47% 9
6 CNRS UP A 7053 114546 0% 80% 4
7 UMR 7149 90413 1% 21% 12
8 RECH CROISSANCE CELLULAIRE 80540 0% 75% 3
9 FRE 2412 80534 1% 38% 6
10 CRRET 74475 2% 13% 16

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 GROWTH FACTORS 2195 1% 1% 7
2 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 1968 7% 0% 62
3 JOURNAL OF BIOCHEMISTRY 1582 3% 0% 22
4 CANCER LETTERS 732 2% 0% 16
5 DEVELOPMENTAL BRAIN RESEARCH 562 1% 0% 9
6 JOURNAL OF BIOLOGICAL CHEMISTRY 541 6% 0% 51
7 CANCER SCIENCE 485 1% 0% 7
8 MOLECULAR AND CELLULAR NEUROSCIENCE 451 1% 0% 6
9 BRITISH JOURNAL OF PHARMACOLOGY 429 2% 0% 15
10 WORLD JOURNAL OF GASTROENTEROLOGY 294 1% 0% 12

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 MIDKINE 8600078 33% 85% 282 Search MIDKINE Search MIDKINE
2 PLEIOTROPHIN 4708195 19% 81% 163 Search PLEIOTROPHIN Search PLEIOTROPHIN
3 HB GAM 492617 2% 81% 17 Search HB+GAM Search HB+GAM
4 HEPARIN BINDING GROWTH ASSOCIATED MOLECULE 303207 1% 71% 12 Search HEPARIN+BINDING+GROWTH+ASSOCIATED+MOLECULE Search HEPARIN+BINDING+GROWTH+ASSOCIATED+MOLECULE
5 HEPARIN AFFIN REGULATORY PEPTIDE 289947 1% 90% 9 Search HEPARIN+AFFIN+REGULATORY+PEPTIDE Search HEPARIN+AFFIN+REGULATORY+PEPTIDE
6 TRUNCATED MIDKINE 254549 1% 89% 8 Search TRUNCATED+MIDKINE Search TRUNCATED+MIDKINE
7 HUMAN MIDKINE 250573 1% 100% 7 Search HUMAN+MIDKINE Search HUMAN+MIDKINE
8 MIDKINE MK 229092 1% 80% 8 Search MIDKINE+MK Search MIDKINE+MK
9 N SYNDECAN 194887 1% 78% 7 Search N+SYNDECAN Search N+SYNDECAN
10 RPTP BETA ZETA 159451 1% 64% 7 Search RPTP+BETA+ZETA Search RPTP+BETA+ZETA

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 MURAMATSU, T , (2011) MIDKINE: A PROMISING MOLECULE FOR DRUG DEVELOPMENT TO TREAT DISEASES OF THE CENTRAL NERVOUS SYSTEM.CURRENT PHARMACEUTICAL DESIGN. VOL. 17. ISSUE 5. P. 410-423 179 92% 39
2 MURAMATSU, T , (2010) MIDKINE, A HEPARIN-BINDING CYTOKINE WITH MULTIPLE ROLES IN DEVELOPMENT, REPAIR AND DISEASES.PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES. VOL. 86. ISSUE 4. P. 410 -425 150 91% 65
3 MURAMATSU, T , (2002) MIDKINE AND PLEIOTROPHIN: TWO RELATED PROTEINS INVOLVED IN DEVELOPMENT, SURVIVAL, INFLAMMATION AND TUMORIGENESIS.JOURNAL OF BIOCHEMISTRY. VOL. 132. ISSUE 3. P. 359 -371 157 92% 214
4 MURAMATSU, T , (2014) STRUCTURE AND FUNCTION OF MIDKINE AS THE BASIS OF ITS PHARMACOLOGICAL EFFECTS.BRITISH JOURNAL OF PHARMACOLOGY. VOL. 171. ISSUE 4. P. 814-826 114 93% 21
5 SAKAMOTO, K , KADOMATSU, K , (2012) MIDKINE IN THE PATHOLOGY OF CANCER, NEURAL DISEASE, AND INFLAMMATION.PATHOLOGY INTERNATIONAL. VOL. 62. ISSUE 7. P. 445-455 99 84% 21
6 KADOMATSU, KJ , MURAMATSU, T , (2004) MIDKINE AND PLEIOTROPHIN IN NEURAL DEVELOPMENT AND CANCER.CANCER LETTERS. VOL. 204. ISSUE 2. P. 127-143 110 78% 202
7 PAPADIMITRIOU, E , MIKELIS, C , LAMPROPOULOU, E , KOUTSIOUMPA, M , THEOCHARI, K , TSIRMOULA, S , THEODOROPOULOU, C , LAMPROU, M , SFAELOU, E , VOURTSIS, D , ET AL (2009) ROLES OF PLEIOTROPHIN IN TUMOR GROWTH AND ANGIOGENESIS.EUROPEAN CYTOKINE NETWORK. VOL. 20. ISSUE 4. P. 180-190 128 73% 15
8 MIKELIS, C , KOUTSIOURNPA, M , PAPADIMITRIOU, E , (2007) PLEIOTROPHIN AS A POSSIBLE NEW TARGET FOR ANGIOGENESIS-RELATED DISEASES AND CANCER.RECENT PATENTS ON ANTI-CANCER DRUG DISCOVERY. VOL. 2. ISSUE 2. P. 175-186 139 68% 13
9 KADOMATSU, K , KISHIDA, S , TSUBOTA, S , (2013) THE HEPARIN-BINDING GROWTH FACTOR MIDKINE: THE BIOLOGICAL ACTIVITIES AND CANDIDATE RECEPTORS.JOURNAL OF BIOCHEMISTRY. VOL. 153. ISSUE 6. P. 511-521 81 82% 36
10 PAPADIMITRIOU, E , PANTAZAKA, E , CASTANA, P , TSALIOS, T , POLYZOS, A , BEIS, D , (2016) PLEIOTROPHIN AND ITS RECEPTOR PROTEIN TYROSINE PHOSPHATASE BETA/ZETA AS REGULATORS OF ANGIOGENESIS AND CANCER.BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER. VOL. 1866. ISSUE 2. P. 252 -265 100 73% 0

Classes with closest relation at Level 1


Rank Class id link
1 37725 FGF BP//FGF BINDING PROTEIN//HBP17 FGFBP 1
2 7748 PERINEURONAL NET//VERSICAN//CHONDROITIN SULFATE PROTEOGLYCAN
3 21364 NUCLEOLIN//SURFACE NUCLEOLIN//AS1411
4 11020 PROTEOGLYCAN SIGNALING THER EUT//CHONDROITIN SULFATE//XYLOSYLTRANSFERASE
5 5267 CRIZOTINIB//ANAPLASTIC LYMPHOMA KINASE//ALK
6 29615 DERMCIDIN//ABO BLOOD GROUPING//SKIN WHEAL RESPONSES
7 6202 SYNDECAN 1//SYNDECAN//SYNDECAN 4
8 33389 PENTOSAN POLYSULFATE//ELMIRON//LASER ANIMAL MODEL
9 1580 PROTEIN TYROSINE PHOSPHATASE//PTP1B//PROTEIN TYROSINE PHOSPHATASE 1B
10 26139 RGTA//DERIVATIZED DEXTRANS//DEXTRAN DERIVATIVES

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