Class information for:
Level 1: ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY

Basic class information
Class id #P Avg. number of
references		 Database coverage
of references
1007 2906 36.4 67%


Bar chart of Publication_year

Last years might be incomplete

Hierarchy of classes
The table includes all classes above and classes immediately below the current class.


Cluster id Level Cluster label #P
0 4 BIOCHEMISTRY & MOLECULAR BIOLOGY//CELL BIOLOGY//ONCOLOGY 4064930
111 3       THROMBOSIS RESEARCH//THROMBOSIS AND HAEMOSTASIS//HEMATOLOGY 71244
1906 2             ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY 5908
1007 1                   ALPHA 1 ANTITRYPSIN DEFICIENCY//ALPHA 1 ANTITRYPSIN//ALPHA1 ANTITRYPSIN DEFICIENCY 2906

Terms with highest relevance score


rank Term termType Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 ALPHA 1 ANTITRYPSIN DEFICIENCY authKW 1308565 6% 69% 181
2 ALPHA 1 ANTITRYPSIN authKW 1112481 8% 43% 247
3 ALPHA1 ANTITRYPSIN DEFICIENCY authKW 770968 4% 69% 107
4 ALPHA1 ANTITRYPSIN authKW 575194 5% 41% 133
5 SERPIN authKW 520413 7% 23% 217
6 ANTITRYPSIN authKW 238303 1% 65% 35
7 AUGMENTATION THERAPY authKW 192051 1% 52% 35
8 SERPINOPATHIES authKW 131318 1% 83% 15
9 SERPINA1 authKW 123582 1% 59% 20
10 PI SUBTYPES authKW 105932 0% 92% 11

Web of Science journal categories


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 Respiratory System 9422 15% 0% 442
2 Biochemistry & Molecular Biology 3982 33% 0% 959
3 Genetics & Heredity 1348 10% 0% 297
4 Critical Care Medicine 964 4% 0% 113
5 Medical Laboratory Technology 902 3% 0% 92
6 Gastroenterology & Hepatology 857 6% 0% 173
7 Biophysics 711 7% 0% 195
8 Medicine, Research & Experimental 626 7% 0% 192
9 Pathology 467 4% 0% 124
10 Medicine, General & Internal 400 7% 0% 206

Address terms


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 LUNG INVEST UNIT 77796 1% 37% 20
2 LUNG FUNCT SLEEP 63551 0% 55% 11
3 PROT STRAIN 52529 0% 100% 5
4 AD T PROJECT 46794 0% 64% 7
5 CAMBRIDGE MED 45316 3% 5% 95
6 EVALUAT RISKS HUMAN REPROD 43773 0% 83% 5
7 BIOCHIM BIOL MOL HMNO 31518 0% 100% 3
8 DIAG INHERITED ANTITRYPSIN DEFICIENCY ALPHA1 31518 0% 100% 3
9 PEDIATUPMC NEWBORN MED PROGRAM 31518 0% 100% 3
10 SPANISH SOC PNEUMOL SEPAR 31518 0% 100% 3

Journals


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class
1 COPD-JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE 23166 1% 6% 37
2 HUMAN HEREDITY 11680 2% 2% 48
3 RESPIRATORY MEDICINE 3446 1% 1% 42
4 HUMAN GENETICS 2480 2% 1% 44
5 ARCHIVOS DE BRONCONEUMOLOGIA 2176 1% 1% 17
6 CHEST 2071 2% 0% 66
7 BIOLOGICAL CHEMISTRY HOPPE-SEYLER 1961 1% 1% 17
8 JOURNAL OF BIOLOGICAL CHEMISTRY 1850 6% 0% 174
9 MOLECULAR BIOLOGY & MEDICINE 1815 0% 3% 6
10 THERAPEUTIC ADVANCES IN RESPIRATORY DISEASE 1622 0% 3% 5

Author Key Words


Rank Term Chi square Shr. of publ. in
class containing
term		 Class's shr. of
term's tot. occurrences		 #P with
term in
class		 LCSH search Wikipedia search
1 ALPHA 1 ANTITRYPSIN DEFICIENCY 1308565 6% 69% 181 Search ALPHA+1+ANTITRYPSIN+DEFICIENCY Search ALPHA+1+ANTITRYPSIN+DEFICIENCY
2 ALPHA 1 ANTITRYPSIN 1112481 8% 43% 247 Search ALPHA+1+ANTITRYPSIN Search ALPHA+1+ANTITRYPSIN
3 ALPHA1 ANTITRYPSIN DEFICIENCY 770968 4% 69% 107 Search ALPHA1+ANTITRYPSIN+DEFICIENCY Search ALPHA1+ANTITRYPSIN+DEFICIENCY
4 ALPHA1 ANTITRYPSIN 575194 5% 41% 133 Search ALPHA1+ANTITRYPSIN Search ALPHA1+ANTITRYPSIN
5 SERPIN 520413 7% 23% 217 Search SERPIN Search SERPIN
6 ANTITRYPSIN 238303 1% 65% 35 Search ANTITRYPSIN Search ANTITRYPSIN
7 AUGMENTATION THERAPY 192051 1% 52% 35 Search AUGMENTATION+THERAPY Search AUGMENTATION+THERAPY
8 SERPINOPATHIES 131318 1% 83% 15 Search SERPINOPATHIES Search SERPINOPATHIES
9 SERPINA1 123582 1% 59% 20 Search SERPINA1 Search SERPINA1
10 PI SUBTYPES 105932 0% 92% 11 Search PI+SUBTYPES Search PI+SUBTYPES

Core articles
The table includes core articles in the class. The following variables is taken into account for the relevance score of an article in a cluster c:
(1) Number of references referring to publications in the class.
(2) Share of total number of active references referring to publications in the class.
(3) Age of the article. New articles get higher score than old articles.
(4) Citation rate, normalized to year.


Rank Reference # ref. in
cl.		 Shr. of ref. in
cl.		 Citations
1 SANTANGELO, S , SCARLATA, S , POETA, ML , BIALAS, AJ , PAONE, G , INCALZI, RA , (2017) ALPHA-1 ANTITRYPSIN DEFICIENCY: CURRENT PERSPECTIVE FROM GENETICS TO DIAGNOSIS AND THERAPEUTIC APPROACHES.CURRENT MEDICINAL CHEMISTRY. VOL. 24. ISSUE 1. P. 65 -90 151 81% 0
2 STOLLER, JK , ABOUSSOUAN, LS , (2012) A REVIEW OF ALPHA(1)-ANTITRYPSIN DEFICIENCY.AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. VOL. 185. ISSUE 3. P. 246 -259 114 80% 83
3 HENAO, MP , CRAIG, TJ , (2016) RECENT ADVANCES IN UNDERSTANDING AND TREATING COPD RELATED TO (1)-ANTITRYPSIN DEFICIENCY.EXPERT REVIEW OF RESPIRATORY MEDICINE. VOL. 10. ISSUE 12. P. 1281 -1294 118 87% 0
4 GOOPTU, B , LOMAS, DA , (2009) CONFORMATIONAL PATHOLOGY OF THE SERPINS: THEMES, VARIATIONS, AND THERAPEUTIC STRATEGIES.ANNUAL REVIEW OF BIOCHEMISTRY. VOL. 78. ISSUE . P. 147-176 111 78% 99
5 GREENE, CM , MARCINIAK, SJ , TECKMAN, J , FERRAROTTI, I , BRANTLY, ML , LOMAS, DA , STOLLER, JK , MCELVANEY, NG , (2016) ALPHA 1-ANTITRYPSIN DEFICIENCY.NATURE REVIEWS DISEASE PRIMERS. VOL. 2. ISSUE . P. - 124 74% 0
6 SALAHUDDIN, P , (2010) GENETIC VARIANTS OF ALPHA(1)-ANTITRYPSIN.CURRENT PROTEIN & PEPTIDE SCIENCE. VOL. 11. ISSUE 2. P. 101-117 119 85% 13
7 DICKENS, JA , LOMAS, DA , (2011) WHY HAS IT BEEN SO DIFFICULT TO PROVE THE EFFICACY OF ALPHA-1-ANTITRYPSIN REPLACEMENT THERAPY? INSIGHTS FROM THE STUDY OF DISEASE PATHOGENESIS.DRUG DESIGN DEVELOPMENT AND THERAPY. VOL. 5. ISSUE . P. 391 -405 104 92% 18
8 GOOPTU, B , DICKENS, JA , LOMAS, DA , (2014) THE MOLECULAR AND CELLULAR PATHOLOGY OF ALPHA(1)-ANTITRYPSIN DEFICIENCY.TRENDS IN MOLECULAR MEDICINE. VOL. 20. ISSUE 2. P. 116 -127 95 86% 17
9 EKEOWA, UI , GOOPTU, B , BELORGEY, D , HAGGLOF, P , KARLSSON-LI, S , MIRANDA, E , PEREZ, J , MACLEOD, I , KROGER, H , MARCINIAK, SJ , ET AL (2009) ALPHA(1)-ANTITRYPSIN DEFICIENCY, CHRONIC OBSTRUCTIVE PULMONARY DISEASE AND THE SERPINOPATHIES.CLINICAL SCIENCE. VOL. 116. ISSUE 11-12. P. 837-850 121 78% 30
10 LOMAS, DA , HURST, JR , GOOPTU, B , (2016) UPDATE ON ALPHA-1 ANTITRYPSIN DEFICIENCY: NEW THERAPIES.JOURNAL OF HEPATOLOGY. VOL. 65. ISSUE 2. P. 413 -424 81 91% 1

Classes with closest relation at Level 1


Rank Class id link
1 7218 ELAFIN//SLPI//SECRETORY LEUKOCYTE PROTEASE INHIBITOR
2 36999 MED HUMANITIES SOCIAL SCI//ANXIETY ABOUT BABYS DIABETES RISK//CLIN RIGHT ISAR
3 18695 COPD RELATED PHENOTYPES//FAM13A//CHRONIC OBSTRUCTIVE PULMONARY DISEASE
4 34165 CHAIR BIOL MED GENET//ASCARIS ALPHA CHYMOTRYPSIN INHIBITOR//ASCARIS HOMOGENATE
5 4206 HEPARIN COFACTOR II//ANTITHROMBIN//ANTITHROMBIN DEFICIENCY
6 16953 PLASMINOGEN ACTIVATOR INHIBITOR TYPE 2//PAI 2//SERPINB2
7 23637 PROTEIN C INHIBITOR//F5F8D//LMAN1
8 27184 ALPHA2 ANTIPLASMIN//CLIN PATHOL BIOCHEM//NC100692
9 16514 ANIMAL BLOOD GROUPS AND BIOCHEMICAL GENETICS//HALOTHANE GENE//RYANODIN RECEPTOR
10 22032 ALPHA 1 ANTICHYMOTRYPSIN//ALPHA1 ANTICHYMOTRYPSIN POLYMORPHISM//SERUM ALPHA1 ANTICHYMOTRYPSIN

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