Class information for:
Level 2: DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
903 10618 31.7 69%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
499 19953 DIHYDROPYRIMIDINE DEHYDROGENASE//5 FLUOROURACIL//THYMIDINE PHOSPHORYLASE

Classes in level below (level 1)


ID, lev. below Publications Label for level below
2158 2267 OXALIPLATIN//CAPECITABINE//IRINOTECAN
4300 1734 ADVANCED GASTRIC CANCER//S 1//METASTATIC GASTRIC CANCER
7541 1276 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYL TRANSFERASE
7749 1253 DIHYDROPYRIMIDINE DEHYDROGENASE//DPYD//DIHYDROPYRIMIDINE DEHYDROGENASE DEFICIENCY
8496 1179 BIOCHEMICAL MODULATION//LEUCOVORIN//FOLINIC ACID
10160 1022 URIDINE PHOSPHORYLASE//5 PHENYLTHIOACYCLOURIDINE//ALPHA D RIBOSE 1 PHOSPHATE
12243 856 THYMIDINE PHOSPHORYLASE//PLATELET DERIVED ENDOTHELIAL CELL GROWTH FACTOR//THYMIDINE PHOSPHORYLASE INHIBITOR
18959 462 VASCULAR TOXICITY//INTERNAL MED PERIOPERAT ASSESSMENT//BOLUS 5 FLUOROURACIL
19700 429 DIPYRIDAMOLE//VASODILATOR DRUG//TUMOR CELL GROWTH AND VIABILITY
30249 140 TULAREMIA LIVE VACCINE//1 HEXYLCARBAMOYL 5 FLUOROURACIL//5 FLUOROURACIL AND 1 HEXYLCARBAMOYL 5 FLUOROURACIL

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class
1 DIHYDROPYRIMIDINE DEHYDROGENASE Author keyword 554 84% 3% 298
2 5 FLUOROURACIL Author keyword 510 32% 12% 1325
3 THYMIDINE PHOSPHORYLASE Author keyword 494 74% 3% 368
4 S 1 Author keyword 322 55% 4% 407
5 THYMIDYLATE SYNTHASE Author keyword 289 48% 4% 443
6 LEUCOVORIN Author keyword 226 54% 3% 290
7 CAPECITABINE Author keyword 222 36% 5% 501
8 ADVANCED GASTRIC CANCER Author keyword 183 56% 2% 222
9 OXALIPLATIN Author keyword 167 27% 5% 538
10 IRINOTECAN Author keyword 136 25% 4% 466

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class		 LCSH search Wikipedia search
1 DIHYDROPYRIMIDINE DEHYDROGENASE 554 84% 3% 298 Search DIHYDROPYRIMIDINE+DEHYDROGENASE Search DIHYDROPYRIMIDINE+DEHYDROGENASE
2 5 FLUOROURACIL 510 32% 12% 1325 Search 5+FLUOROURACIL Search 5+FLUOROURACIL
3 THYMIDINE PHOSPHORYLASE 494 74% 3% 368 Search THYMIDINE+PHOSPHORYLASE Search THYMIDINE+PHOSPHORYLASE
4 S 1 322 55% 4% 407 Search S+1 Search S+1
5 THYMIDYLATE SYNTHASE 289 48% 4% 443 Search THYMIDYLATE+SYNTHASE Search THYMIDYLATE+SYNTHASE
6 LEUCOVORIN 226 54% 3% 290 Search LEUCOVORIN Search LEUCOVORIN
7 CAPECITABINE 222 36% 5% 501 Search CAPECITABINE Search CAPECITABINE
8 ADVANCED GASTRIC CANCER 183 56% 2% 222 Search ADVANCED+GASTRIC+CANCER Search ADVANCED+GASTRIC+CANCER
9 OXALIPLATIN 167 27% 5% 538 Search OXALIPLATIN Search OXALIPLATIN
10 IRINOTECAN 136 25% 4% 466 Search IRINOTECAN Search IRINOTECAN

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class
1 FLUOROURACIL 766 29% 21% 2271
2 5 FLUOROURACIL 622 26% 19% 2058
3 FOLINIC ACID 456 46% 7% 731
4 DIHYDROPYRIMIDINE DEHYDROGENASE 390 60% 4% 429
5 LEUCOVORIN 362 30% 10% 1011
6 BIOCHEMICAL MODULATION 360 75% 2% 257
7 HIGH DOSE LEUCOVORIN 304 57% 3% 362
8 5 DEOXY 5 FLUOROURIDINE 263 80% 2% 165
9 DPD DEFICIENCY 255 93% 1% 95
10 ADVANCED ESOPHAGOGASTRIC CANCER 236 60% 2% 255

Journals


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CLINICAL COLORECTAL CANCER 14 18% 1% 70
2 GASTRIC CANCER 14 15% 1% 83
3 GI CANCER 2 13% 0% 13

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
5-Fluorouracil: Mechanisms of action and clinical strategies 2003 1149 96 70%
A Review of the Evolution of Systemic Chemotherapy in the Management of Colorectal Cancer 2015 3 61 67%
How folate metabolism affects colorectal cancer development and treatment; a story of heterogeneity and pleiotropy 2015 2 60 55%
Current questions for the treatment of advanced gastric cancer 2013 29 44 82%
Chemotherapy for advanced gastric cancer 2010 76 114 71%
Pharmacogenomics of fluorouracil-based chemotherapy toxicity 2015 1 72 88%
5-fluorouracil induced cardiotoxicity: Review of the literature 2012 26 42 93%
Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis 2004 278 49 80%
Capecitabine: A review 2005 209 60 58%
FLUOROURACIL - BIOCHEMISTRY AND PHARMACOLOGY 1988 634 39 90%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PATHOGEN BIOCHEM MED 41 100% 0.1% 15
2 CANC 2 19 74% 0.1% 14
3 GERCOR 15 77% 0.1% 10
4 GASTROINTESTINAL ONCOL 14 13% 1.0% 101
5 EPIDEMIOL CLIN INFORMAT MANAGEMENT 11 38% 0.2% 23
6 TOKUSHIMA 11 18% 0.5% 53
7 GASTROINTESTINAL ONCOL DIGEST ENDOSCOPY 9 39% 0.2% 19
8 ONCOPHARMACOL UNIT 9 29% 0.2% 26
9 INO F 8 70% 0.1% 7
10 TOYOSU HOSP 7 28% 0.2% 20

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000018283 CAMPTOTHECIN//SN 38//TOPOTECAN
2 0.0000014647 CHEMOTHERAPY INDUCED PERIPHERAL NEUROPATHY//VINFLUNINE//VINCRISTINE
3 0.0000013191 FOLATE RECEPTOR//REDUCED FOLATE CARRIER//DIHYDROFOLATE REDUCTASE
4 0.0000012667 GASTRIC CANCER//GASTRECTOMY//TOTAL GASTRECTOMY
5 0.0000012438 MICROSATELLITE INSTABILITY//LYNCH SYNDROME//HNPCC
6 0.0000010219 DEOXYCYTIDINE KINASE//PURINE NUCLEOSIDE PHOSPHORYLASE//NUCLEOSIDE TRANSPORT
7 0.0000010090 POLYNUCLEOTIDE ANALOGUE//QUIM FARMACEUT ORGAN//BENZODIOXEPINS
8 0.0000009542 RADIO FREQUENCY ABLATION//LIVER RESECTION//LIVER METASTASES
9 0.0000009312 NON SMALL CELL LUNG CANCER//XRCC1//GEFITINIB
10 0.0000008708 HAND FOOT SYNDROME//RADIATION RECALL//EXTRAVASATION