Class information for:
Level 2: CYTOCHROME P450//CYP2D6//PREGNANE X RECEPTOR

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
395 16247 41.6 75%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
408 26180 CYTOCHROME P450//GSTM1//GSTT1

Classes in level below (level 1)


ID, lev. below Publications Label for level below
1579 2503 CYP2D6//DEBRISOQUINE//CYP2C19
2213 2246 CYP2C12//ONE DAY TREATMENT//S BIOCHEM
4336 1729 PREGNANE X RECEPTOR//PXR//CONSTITUTIVE ANDROSTANE RECEPTOR
4557 1692 PUTIDAREDOXIN//CYTOCHROME P450CAM//CYP106A2
6192 1453 CYP3A//COCKTAIL//MECHANISM BASED INHIBITION
6713 1378 ANTLEY BIXLER SYNDROME//CYTOCHROME P450 OXIDOREDUCTASE//NADPH CYTOCHROME P450 REDUCTASE
7216 1316 SITE OF METABOLISM//ACTIVE SITE TOPOLOGY//COMPUTAT CHEM MOL STRUCT
11620 902 ROLLINS 5119//ANTIPYRINE PHARMACOKINETICS//CYTOCHROME P4502B1 2
12369 846 CYP2A6//CYP2A5//CYP2A13
14400 706 CYP1B1//CYP2S1//CYTOCHROME P4501B1
21474 359 MARIE LOWE COMPARAT ONCOL//CYP2D//MARI LOWE COMPARAT ONCOL
21966 342 LIVER SLICES//PRECISION CUT TISSUE SLICES//PRECISION CUT LIVER SLICES
23706 282 GV TB//RECONSTRUCTED HUMAN SKIN MODELS//DIP FARMACOBIOL
23988 274 PHARMACOKINET BIOANAL//CYP2D19//PROPRANOLOL ENANTIOMER
26013 219 CYTOCHROME P450NOR//FUNGAL DENITRIFICATION//P450NOR

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class
1 CYTOCHROME P450 Author keyword 485 25% 10% 1681
2 CYP2D6 Author keyword 309 47% 3% 487
3 PREGNANE X RECEPTOR Author keyword 229 71% 1% 187
4 DRUG METABOLISM AND DISPOSITION Journal 167 15% 6% 1054
5 DEBRISOQUINE Author keyword 165 76% 1% 116
6 CONSTITUTIVE ANDROSTANE RECEPTOR Author keyword 158 78% 1% 105
7 PXR Author keyword 150 60% 1% 164
8 DRUG METABOLISM Author keyword 147 27% 3% 460
9 CYP2A6 Author keyword 98 59% 1% 110
10 CYP3A4 Author keyword 96 28% 2% 293

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class		 LCSH search Wikipedia search
1 CYTOCHROME P450 485 25% 10% 1681 Search CYTOCHROME+P450 Search CYTOCHROME+P450
2 CYP2D6 309 47% 3% 487 Search CYP2D6 Search CYP2D6
3 PREGNANE X RECEPTOR 229 71% 1% 187 Search PREGNANE+X+RECEPTOR Search PREGNANE+X+RECEPTOR
4 DEBRISOQUINE 165 76% 1% 116 Search DEBRISOQUINE Search DEBRISOQUINE
5 CONSTITUTIVE ANDROSTANE RECEPTOR 158 78% 1% 105 Search CONSTITUTIVE+ANDROSTANE+RECEPTOR Search CONSTITUTIVE+ANDROSTANE+RECEPTOR
6 PXR 150 60% 1% 164 Search PXR Search PXR
7 DRUG METABOLISM 147 27% 3% 460 Search DRUG+METABOLISM Search DRUG+METABOLISM
8 CYP2A6 98 59% 1% 110 Search CYP2A6 Search CYP2A6
9 CYP3A4 96 28% 2% 293 Search CYP3A4 Search CYP3A4
10 ANTLEY BIXLER SYNDROME 89 84% 0% 48 Search ANTLEY+BIXLER+SYNDROME Search ANTLEY+BIXLER+SYNDROME

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class
1 DRUG METABOLISM 430 31% 7% 1154
2 PREGNANE X RECEPTOR 424 42% 5% 781
3 CONSTITUTIVE ANDROSTANE RECEPTOR 415 50% 4% 592
4 HUMAN LIVER MICROSOMES 374 26% 8% 1227
5 P 450 REDUCTASE 332 65% 2% 314
6 DEBRISOQUINE 296 51% 3% 418
7 XENOBIOTIC RECEPTOR 266 81% 1% 158
8 PXR 239 71% 1% 194
9 P450 236 43% 3% 417
10 COUMARIN 7 HYDROXYLATION 204 86% 1% 102

Journals


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of publ.
in class
1 DRUG METABOLISM AND DISPOSITION 167 15% 6% 1054
2 XENOBIOTICA 55 12% 3% 438
3 PHARMACOGENETICS 53 22% 1% 210
4 CURRENT DRUG METABOLISM 29 17% 1% 161
5 DRUG METABOLISM REVIEWS 17 13% 1% 122
6 DRUG METABOLISM AND PHARMACOKINETICS 16 15% 1% 97

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation 2013 173 551 35%
P450(BM3) (CYP102A1): connecting the dots 2012 102 408 83%
Cytochrome P450 monooxygenases: an update on perspectives for synthetic application 2012 91 80 80%
Cytochrome P-450 3A4: Regulation and role in drug metabolism 1999 701 93 67%
THE P450 SUPERFAMILY - UPDATE ON NEW SEQUENCES, GENE-MAPPING, ACCESSION NUMBERS, EARLY TRIVIAL NAMES OF ENZYMES, AND NOMENCLATURE 1993 1394 547 50%
Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry 2004 385 131 89%
Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functional diversity 2005 387 49 80%
Heme Enzyme Structure and Function 2014 47 314 21%
Cytochrome P450 and chemical toxicology 2008 435 143 34%
Drugs behave as substrates, inhibitors and inducers of human cytochrome P450 3A4 2008 215 143 63%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PHARMACOGENET SECT 95 53% 0.8% 125
2 PHARMACOKINET BIOANAL 42 59% 0.3% 47
3 DRUG METAB 30 13% 1.3% 208
4 MOL TOXICOL 30 12% 1.5% 242
5 REPROD DEV TOXICOL 17 16% 0.6% 95
6 SECT DEV PHARMACOL EXPT THER EUT 15 56% 0.1% 18
7 CICAB CLIN 12 58% 0.1% 14
8 MOL TOXICOL GRP 11 22% 0.3% 45
9 PHARMACOGENET 11 11% 0.5% 89
10 UNIDAD HEPATOL EXPT 10 26% 0.2% 35

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000018458 SOLUBLE EPOXIDE HYDROLASE//EPOXYEICOSATRIENOIC ACIDS//EPOXIDE HYDROLASE
2 0.0000016290 TCDD//ARYL HYDROCARBON RECEPTOR//2 3 7 8 TETRACHLORODIBENZO P DIOXIN
3 0.0000013946 FLAVIN CONTAINING MONOOXYGENASE//FMO3//TRIMETHYLAMINURIA
4 0.0000011884 JOURNAL OF PHARMACOKINETICS AND BIOPHARMACEUTICS//JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS//NONMEM
5 0.0000011109 VISNAGIN//AMMI VISNAGA//FURANOCHROMONES
6 0.0000009693 GSTM1//GSTT1//GLUTATHIONE S TRANSFERASE
7 0.0000009493 GRAPTOPETALUM PARAGUAYENSE E WALTHER//AGR CHEM CHIKUSA KU//AGR CHEM NUTR BIOCHEM
8 0.0000008160 BIOANALYSIS//LC NMR//DRIED BLOOD SPOT DBS
9 0.0000007891 2 METHOXYESTRADIOL//INDOLE 3 CARBINOL//3 3 DIINDOLYLMETHANE
10 0.0000007706 HETEROCYCLIC AMINES//HETEROCYCLIC AROMATIC AMINES//ARYLAMINE N ACETYLTRANSFERASE