Class information for:
Level 2: NOONAN SYNDROME//COSTELLO SYNDROME//THROMBOSPONDIN 1

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
2325 4032 41.2 87%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
630 9614 NOONAN SYNDROME//COSTELLO SYNDROME//PROTEIN TYROSINE PHOSPHATASE

Classes in level below (level 1)


ID, lev. below Publications Label for level below
6343 1431 THROMBOSPONDIN 1//THROMBOSPONDIN//ANGIOCIDIN
9644 1069 SHP 2//SHP 1//GAB1
9898 1046 NOONAN SYNDROME//COSTELLO SYNDROME//LEOPARD SYNDROME
18459 486 SHPS 1//BIOSIGNAL SCI//CD47

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 NOONAN SYNDROME Author keyword 469 78% 8% 313
2 COSTELLO SYNDROME Author keyword 271 88% 3% 127
3 THROMBOSPONDIN 1 Author keyword 174 55% 5% 219
4 PTPN11 Author keyword 148 75% 3% 106
5 THROMBOSPONDIN Author keyword 129 48% 5% 198
6 LEOPARD SYNDROME Author keyword 114 80% 2% 70
7 CARDIO FACIO CUTANEOUS SYNDROME Author keyword 113 91% 1% 48
8 SHP 2 Author keyword 99 47% 4% 156
9 SHPS 1 Author keyword 90 96% 1% 27
10 CD47 Author keyword 79 57% 2% 93

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 NOONAN SYNDROME 469 78% 8% 313 Search NOONAN+SYNDROME Search NOONAN+SYNDROME
2 COSTELLO SYNDROME 271 88% 3% 127 Search COSTELLO+SYNDROME Search COSTELLO+SYNDROME
3 THROMBOSPONDIN 1 174 55% 5% 219 Search THROMBOSPONDIN+1 Search THROMBOSPONDIN+1
4 PTPN11 148 75% 3% 106 Search PTPN11 Search PTPN11
5 THROMBOSPONDIN 129 48% 5% 198 Search THROMBOSPONDIN Search THROMBOSPONDIN
6 LEOPARD SYNDROME 114 80% 2% 70 Search LEOPARD+SYNDROME Search LEOPARD+SYNDROME
7 CARDIO FACIO CUTANEOUS SYNDROME 113 91% 1% 48 Search CARDIO+FACIO+CUTANEOUS+SYNDROME Search CARDIO+FACIO+CUTANEOUS+SYNDROME
8 SHP 2 99 47% 4% 156 Search SHP+2 Search SHP+2
9 SHPS 1 90 96% 1% 27 Search SHPS+1 Search SHPS+1
10 CD47 79 57% 2% 93 Search CD47 Search CD47

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 INTEGRIN ASSOCIATED PROTEIN 268 67% 6% 245
2 PLATELET THROMBOSPONDIN 188 76% 3% 132
3 PTPN11 MUTATIONS 188 79% 3% 119
4 FACIO CUTANEOUS SYNDROME 124 60% 3% 134
5 NOONAN SYNDROME 119 41% 6% 223
6 HUMAN PLATELET THROMBOSPONDIN 113 91% 1% 48
7 SECRETE THROMBOSPONDIN 112 89% 1% 50
8 CFC SYNDROME 111 83% 2% 63
9 CORKSCREW 109 92% 1% 44
10 SH2 CONTAINING PHOSPHOTYROSINE PHOSPHATASE 101 57% 3% 119

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
The Interaction Between Signal Regulatory Protein Alpha (SIRP alpha) and CD47: Structure, Function, and Therapeutic Target 2014 18 148 74%
Noonan Syndrome: Clinical Features, Diagnosis, and Management Guidelines 2010 91 110 95%
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling 2003 596 92 64%
The RASopathies 2013 47 63 57%
The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation 2009 206 49 47%
Functions and molecular mechanisms of the CD47-SIRP alpha signalling pathway 2009 95 84 89%
Thrombospondins in cancer 2008 112 100 78%
Thrombospondin-1 as an endogenous inhibitor of angiogenesis and tumor growth 2002 253 64 91%
Costello syndrome: a Ras/mitogen activated protein kinase pathway syndrome (rasopathy) resulting from HRAS germline mutations 2012 27 39 97%
Current understanding of the thrombospondin-1 interactome 2014 8 106 67%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 BIOSIGNAL SCI 54 75% 1.0% 39
2 SECT HISTOL CELL BIOL 11 38% 0.6% 23
3 DIPARTIMENTO BIOL CELLULARE NEUROSCI 8 24% 0.7% 28
4 DIPARTIMENTO EMATOL ONCOL MED MOL 6 28% 0.4% 18
5 IST CLIN PEDIAT 4 18% 0.5% 22
6 UNIV HOSP PRAGUE 4 75% 0.1% 3
7 MOL CELLULAR SIGNALING 4 19% 0.5% 20
8 PROGRAM STEM CELLS REGENERAT 4 56% 0.1% 5
9 BIOCHEM PATHOL SECT 3 57% 0.1% 4
10 MORT CELLULAIRE PROGRAMMEE PHYSIOPATHOL CELLULE 3 100% 0.1% 3

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000028907 PTP1B//PROTEIN TYROSINE PHOSPHATASE//PRL 3
2 0.0000016068 SPARC//GROWTH DIFFERENTIATION FACTOR 15//GDF 15
3 0.0000014262 NEUROFIBROMATOSIS TYPE 1//NEUROFIBROMATOSIS//NF1
4 0.0000011762 PEDF//PIGMENT EPITHELIUM DERIVED FACTOR//PIGMENT EPITHELIUM DERIVED FACTOR PEDF
5 0.0000009165 STAT3//INTERLEUKIN 7//SOCS
6 0.0000008085 LYMPHANGIOGENESIS//ANGIOGENESIS//ENDOSTATIN
7 0.0000008079 HEPATOCYTE GROWTH FACTOR//C MET//HGF
8 0.0000007333 X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK
9 0.0000007253 FOCAL ADHESION KINASE//INTEGRIN LINKED KINASE//FAK
10 0.0000007035 ALPHAVBETA3 INTEGRIN//CILENGITIDE//DISCOIDIN DOMAIN RECEPTOR