Class information for:
Level 2: LESCH NYHAN SYNDROME//TIAZOFURIN//LESCH NYHAN DISEASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
1852 5569 32.3 59%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
465 22192 NM23//RIBONUCLEOTIDE REDUCTASE//DEOXYCYTIDINE KINASE

Classes in level below (level 1)


ID, lev. below Publications Label for level below
9202 1109 DIHYDROOROTASE//CARBAMOYL PHOSPHATE SYNTHETASE//ASPARTATE CARBAMOYLTRANSFERASE
10450 996 TIAZOFURIN//BENZAMIDE RIBOSIDE//IMPDH
14962 670 LESCH NYHAN SYNDROME//LESCH NYHAN DISEASE//LESCH NYHAN
15108 662 ADENYLOSUCCINATE LYASE DEFICIENCY//ADENYLOSUCCINATE LYASE//PURINE BIOSYNTHESIS
15794 622 PHOSPHORIBOSYLTRANSFERASE//MOL PARASITOL DRUG DESIGN//HGXPRT
20276 405 CARAB//PYRIMIDINE REGULATION//PYRR
22824 311 PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE//PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE//ARTHROBACTER A302
24600 257 ODCASE//OROTIDINE 5 MONOPHOSPHATE DECARBOXYLASE//MOL DESIGN PREFORMULAT
26288 213 CYCLOPENTENYL CYTOSINE//CTP SYNTHASE//CTP SYNTHETASE
26903 199 APRT DEFICIENCY//ADENINE PHOSPHORIBOSYLTRANSFERASE DEFICIENCY//2 8 DIHYDROXYADENINE
31269 125 CIZ1//ENHANCER OF RUDIMENTARY//APICAL EXTRACELLULAR MATRIX

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 LESCH NYHAN SYNDROME Author keyword 161 81% 2% 96
2 TIAZOFURIN Author keyword 83 76% 1% 59
3 LESCH NYHAN DISEASE Author keyword 75 80% 1% 47
4 CYCLOPENTENYL CYTOSINE Author keyword 69 93% 0% 26
5 CTP SYNTHASE Author keyword 61 95% 0% 20
6 PHOSPHORIBOSYLTRANSFERASE Author keyword 58 80% 1% 36
7 PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE Author keyword 53 95% 0% 18
8 BENZAMIDE RIBOSIDE Author keyword 41 87% 0% 20
9 ADENYLOSUCCINATE LYASE DEFICIENCY Author keyword 41 100% 0% 15
10 PYRIMIDINE BIOSYNTHESIS Author keyword 40 56% 1% 48

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 LESCH NYHAN SYNDROME 161 81% 2% 96 Search LESCH+NYHAN+SYNDROME Search LESCH+NYHAN+SYNDROME
2 TIAZOFURIN 83 76% 1% 59 Search TIAZOFURIN Search TIAZOFURIN
3 LESCH NYHAN DISEASE 75 80% 1% 47 Search LESCH+NYHAN+DISEASE Search LESCH+NYHAN+DISEASE
4 CYCLOPENTENYL CYTOSINE 69 93% 0% 26 Search CYCLOPENTENYL+CYTOSINE Search CYCLOPENTENYL+CYTOSINE
5 CTP SYNTHASE 61 95% 0% 20 Search CTP+SYNTHASE Search CTP+SYNTHASE
6 PHOSPHORIBOSYLTRANSFERASE 58 80% 1% 36 Search PHOSPHORIBOSYLTRANSFERASE Search PHOSPHORIBOSYLTRANSFERASE
7 PHOSPHORIBOSYLPYROPHOSPHATE SYNTHETASE 53 95% 0% 18 Search PHOSPHORIBOSYLPYROPHOSPHATE+SYNTHETASE Search PHOSPHORIBOSYLPYROPHOSPHATE+SYNTHETASE
8 BENZAMIDE RIBOSIDE 41 87% 0% 20 Search BENZAMIDE+RIBOSIDE Search BENZAMIDE+RIBOSIDE
9 ADENYLOSUCCINATE LYASE DEFICIENCY 41 100% 0% 15 Search ADENYLOSUCCINATE+LYASE+DEFICIENCY Search ADENYLOSUCCINATE+LYASE+DEFICIENCY
10 PYRIMIDINE BIOSYNTHESIS 40 56% 1% 48 Search PYRIMIDINE+BIOSYNTHESIS Search PYRIMIDINE+BIOSYNTHESIS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 OMP DECARBOXYLASE 206 98% 1% 52
2 PROFICIENT ENZYME 178 84% 2% 98
3 CARBAMOYLTRANSFERASE 167 76% 2% 118
4 IMP DEHYDROGENASE 165 57% 3% 193
5 MONOPHOSPHATE DECARBOXYLASE 155 95% 1% 53
6 5 PHOSPHATE DECARBOXYLASE 150 96% 1% 47
7 5 MONOPHOSPHATE DEHYDROGENASE 143 83% 1% 80
8 MONOPHOSPHATE DEHYDROGENASE 137 88% 1% 65
9 HYPOXANTHINE GUANINE PHOSPHORIBOSYLTRANSFERASE 133 60% 3% 145
10 INOSINE 5 MONOPHOSPHATE DEHYDROGENASE 123 70% 2% 103

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
IMP Dehydrogenase: Structure, Mechanism, and Inhibition 2009 80 229 72%
Genotype-phenotype correlations in neurogenetics: Lesch-Nyhan disease as a model disorder 2014 5 123 97%
Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis 2005 86 60 85%
Recent development of IMP dehydrogenase inhibitors for the treatment of cancer 2007 54 82 89%
Adenylosuccinate lyase deficiency 2015 1 64 89%
Mammalian pyrimidine biosynthesis: Fresh insights into an ancient pathway 2004 95 55 75%
From feedback inhibition to allostery: the enduring example of aspartate transcarbamoylase 2014 4 11 82%
Hypoxanthine-guanine phosophoribosyltransferase (HPRT) deficiency: Lesch-Nyhan syndrome 2007 43 63 92%
Catalytic proficiency: The unusual case of OMP decarboxylase 2002 153 63 56%
Regulation of pyrimidine biosynthetic gene expression in bacteria: Repression without repressors 2008 50 150 67%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 MOL PARASITOL DRUG DESIGN 34 93% 0.2% 13
2 MED BIOCHEM GENET METAB 12 86% 0.1% 6
3 MOL DESIGN PREFORMULAT 5 42% 0.2% 10
4 PURINE NEUROSCI 5 63% 0.1% 5
5 ERFELIJKHEIDSLEER MICROBIOL 5 41% 0.2% 9
6 ARTHUR F SCOTT CHEM 4 67% 0.1% 4
7 METAB VASC UNIT 4 56% 0.1% 5
8 BIOCHIM SIGNAUX REGULATEURS CELLULAI MOL 3 24% 0.2% 12
9 FINE CHEM BIOCHEM 3 100% 0.1% 3
10 UMR 7631 3 27% 0.2% 10

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000017263 DEOXYCYTIDINE KINASE//PURINE NUCLEOSIDE PHOSPHORYLASE//NUCLEOSIDE TRANSPORT
2 0.0000014861 LEFLUNOMIDE//LINOMIDE//MIZORIBINE
3 0.0000012669 TRANSHYDROGENASE//WLDS//NAD KINASE
4 0.0000012202 ADENYLATE KINASE//THYMIDYLATE KINASE//CHIM STRUCT MACROMOL
5 0.0000011672 ARGINASE//ORNITHINE TRANSCARBAMYLASE DEFICIENCY//SLC25A13
6 0.0000010008 DIETARY NUCLEOTIDES//URINARY NUCLEOSIDES//BACTERIAL PROTEIN MEAL
7 0.0000008878 HYDANTOINASE//D HYDANTOINASE//DIRECTED EVOLUTION
8 0.0000007580 RIBONUCLEOTIDE REDUCTASE//TRIMIDOX//DIDOX
9 0.0000007148 ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY//ACTA CRYSTALLOGRAPHICA SECTION A//JOURNAL OF APPLIED CRYSTALLOGRAPHY
10 0.0000006527 ALANINE RACEMASE//TYROSINE PHENOL LYASE//MURD