Class information for:
Level 2: PHENYLKETONURIA//TETRAHYDROBIOPTERIN//HYPERPHENYLALANINEMIA

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
1431 7403 32.6 65%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 3)


ID, lev.
above		 Publications Label for level above
607 11441 PHENYLKETONURIA//TETRAHYDROBIOPTERIN//NEOPTERIN

Classes in level below (level 1)


ID, lev. below Publications Label for level below
1950 2346 PHENYLKETONURIA//PKU//HYPERPHENYLALANINEMIA
3103 1983 TETRAHYDROBIOPTERIN//DOPA RESPONSIVE DYSTONIA//GTP CYCLOHYDROLASE I
8458 1182 PHENYLALANINE HYDROXYLASE//TRYPTOPHAN HYDROXYLASE//AROMATIC AMINO ACID HYDROXYLASE
10690 975 NEOPTERIN//7 8 DIHYDRONEOPTERIN//PTERIDINES
14837 678 PHENYLETHANOLAMINE N METHYLTRANSFERASE//PSYCHIAT MOL DEV NEUROBIOL//TYROSINE HYDROXYLASE GENE
25221 239 LUMAZINE//WHITMANIA PIGRA//PTERIDINE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PHENYLKETONURIA Author keyword 1114 78% 10% 741
2 TETRAHYDROBIOPTERIN Author keyword 584 66% 7% 538
3 HYPERPHENYLALANINEMIA Author keyword 381 91% 2% 162
4 PHENYLALANINE HYDROXYLASE Author keyword 357 84% 3% 198
5 NEOPTERIN Author keyword 288 47% 6% 450
6 PKU Author keyword 272 85% 2% 141
7 PTERIDINES Journal 226 61% 3% 239
8 DOPA RESPONSIVE DYSTONIA Author keyword 163 86% 1% 84
9 GTP CYCLOHYDROLASE I Author keyword 132 71% 1% 106
10 MATERNAL PHENYLKETONURIA Author keyword 126 95% 1% 41

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 PHENYLKETONURIA 1114 78% 10% 741 Search PHENYLKETONURIA Search PHENYLKETONURIA
2 TETRAHYDROBIOPTERIN 584 66% 7% 538 Search TETRAHYDROBIOPTERIN Search TETRAHYDROBIOPTERIN
3 HYPERPHENYLALANINEMIA 381 91% 2% 162 Search HYPERPHENYLALANINEMIA Search HYPERPHENYLALANINEMIA
4 PHENYLALANINE HYDROXYLASE 357 84% 3% 198 Search PHENYLALANINE+HYDROXYLASE Search PHENYLALANINE+HYDROXYLASE
5 NEOPTERIN 288 47% 6% 450 Search NEOPTERIN Search NEOPTERIN
6 PKU 272 85% 2% 141 Search PKU Search PKU
7 DOPA RESPONSIVE DYSTONIA 163 86% 1% 84 Search DOPA+RESPONSIVE+DYSTONIA Search DOPA+RESPONSIVE+DYSTONIA
8 GTP CYCLOHYDROLASE I 132 71% 1% 106 Search GTP+CYCLOHYDROLASE+I Search GTP+CYCLOHYDROLASE+I
9 MATERNAL PHENYLKETONURIA 126 95% 1% 41 Search MATERNAL+PHENYLKETONURIA Search MATERNAL+PHENYLKETONURIA
10 SAPROPTERIN 122 95% 1% 40 Search SAPROPTERIN Search SAPROPTERIN

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 HYPERPHENYLALANINEMIA 838 88% 5% 389
2 PKU 455 93% 2% 175
3 BIOPTERIN 323 78% 3% 212
4 PHENYLKETONURIA 286 49% 6% 428
5 EARLY TREATED PHENYLKETONURIA 260 86% 2% 133
6 PHENYLALANINE HYDROXYLASE DEFICIENCY 245 88% 2% 114
7 AMINO ACID HYDROXYLASES 200 72% 2% 158
8 6 PYRUVOYL TETRAHYDROPTERIN SYNTHASE 195 92% 1% 78
9 TETRAHYDROBIOPTERIN 183 34% 6% 447
10 4A CARBINOLAMINE DEHYDRATASE 157 100% 1% 42

Journals


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 PTERIDINES 226 61% 3% 239

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Intricate regulation of tyrosine hydroxylase activity and gene expression 1996 498 183 85%
Tetrahydrobiopterin biosynthesis, regeneration and functions 2000 463 125 86%
Tetrahydrobiopterin: biochemistry and pathophysiology 2011 75 207 76%
Tetrahydropterin-dependent amino acid hydroxylases 1999 260 124 93%
Tyrosine hydroxylase phosphorylation: regulation and consequences 2004 226 108 84%
Neopterin as a marker for immune system activation 2002 262 108 79%
Tyrosine hydroxylase and regulation of dopamine synthesis 2011 67 70 57%
Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease 2004 251 97 59%
Suboptimal outcomes in patients with PKU treated early with diet alone: Revisiting the evidence 2010 39 156 95%
Diagnosis, classification, and genetics of phenylketonuria and tetrahydrobiopterin (BH4) deficiencies 2011 32 36 94%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 UNIDAD ENFERMENDADES METAB 23 100% 0.1% 10
2 MED CHEM BIOCHEM 21 13% 2.1% 155
3 CLIN CHEM BIOCHEM 19 18% 1.3% 98
4 GERONTOL METAB CARE 19 49% 0.4% 28
5 PKU FOLLOW UP UNIT 14 100% 0.1% 7
6 DEBELLE 13 69% 0.1% 11
7 MED CHEM BIOCHEM FRITZ PREGL STR 3 12 53% 0.2% 16
8 PSYCHIAT MOL DEV NEUROBIOL 12 86% 0.1% 6
9 PKU PROGRAM 9 83% 0.1% 5
10 PKU CLIN 8 100% 0.1% 5

Related classes at same level (level 2)


Rank Relatedness score Related classes
1 0.0000010053 INDOLEAMINE 2 3 DIOXYGENASE//KYNURENIC ACID//KYNURENINE
2 0.0000006740 MAPLE SYRUP URINE DISEASE//METHYLMALONIC ACIDEMIA//JOURNAL OF INHERITED METABOLIC DISEASE
3 0.0000005453 NITRIC OXIDE//PEROXYNITRITE//NITRIC OXIDE-BIOLOGY AND CHEMISTRY
4 0.0000005146 ALKAPTONURIA//OCHRONOSIS//HOMOGENTISIC ACID
5 0.0000005102 14 3 3 PROTEINS//14 3 3 SIGMA//14 3 3
6 0.0000005093 GALACTOSEMIA//GALACTOSE 1 PHOSPHATE URIDYLTRANSFERASE//GALACTOSE 1 PHOSPHATE
7 0.0000004751 SUBCOMMISSURAL ORGAN//REISSNERS FIBER//SCO SPONDIN
8 0.0000004175 DYSTONIA//ESSENTIAL TREMOR//CERVICAL DYSTONIA
9 0.0000003980 ALPHA SYNUCLEIN//PARKIN//LRRK2
10 0.0000003826 RASAGILINE//SELEGILINE//DEPRENYL