Class information for:
Level 1: MDM2//MDMX//NUTLIN 3

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
947 2858 51.1 94%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
968 10232 P73//MDM2//P53

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 MDM2 Author keyword 260 38% 19% 552
2 MDMX Author keyword 186 86% 3% 94
3 NUTLIN 3 Author keyword 69 64% 2% 68
4 MDM4 Author keyword 63 71% 2% 50
5 NUTLIN Author keyword 59 78% 1% 39
6 HDM2 Author keyword 52 52% 2% 71
7 HDMX Author keyword 44 88% 1% 21
8 PRIMA 1 Author keyword 30 69% 1% 25
9 P53 MDM2 INTERACTION Author keyword 23 79% 1% 15
10 P53 Address 23 51% 1% 32

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 MDM2 260 38% 19% 552 Search MDM2 Search MDM2
2 MDMX 186 86% 3% 94 Search MDMX Search MDMX
3 NUTLIN 3 69 64% 2% 68 Search NUTLIN+3 Search NUTLIN+3
4 MDM4 63 71% 2% 50 Search MDM4 Search MDM4
5 NUTLIN 59 78% 1% 39 Search NUTLIN Search NUTLIN
6 HDM2 52 52% 2% 71 Search HDM2 Search HDM2
7 HDMX 44 88% 1% 21 Search HDMX Search HDMX
8 PRIMA 1 30 69% 1% 25 Search PRIMA+1 Search PRIMA+1
9 P53 MDM2 INTERACTION 23 79% 1% 15 Search P53+MDM2+INTERACTION Search P53+MDM2+INTERACTION
10 CP 31398 19 76% 0% 13 Search CP+31398 Search CP+31398

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 MDM2 DEFICIENT MICE 227 60% 9% 245
2 ONCOPROTEIN MDM2 214 64% 7% 209
3 MDM2 124 23% 16% 468
4 P53 MDM2 INTERACTION 96 73% 3% 74
5 SUPPRESSOR TRANSACTIVATION DOMAIN 76 86% 1% 38
6 P53 ASSOCIATED PROTEIN 72 93% 1% 27
7 TUMOR SUPPRESSOR P53 71 20% 11% 319
8 CORE DOMAIN 68 39% 5% 138
9 P53 BINDING PROTEIN 66 74% 2% 50
10 P53 PATHWAY 64 34% 5% 154

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
MDM2, MDMX and p53 in oncogenesis and cancer therapy 2013 153 171 68%
Modes of p53 Regulation 2009 616 142 59%
Blinded by the Light: The Growing Complexity of p53 2009 1004 220 35%
Drugging the p53 pathway: understanding the route to clinical efficacy 2014 29 229 61%
Pharmacological reactivation of p53 as a strategy to treat cancer 2015 4 92 62%
The p53 orchestra: Mdm2 and Mdmx set the tone 2010 174 126 66%
MDM2 inhibitors for cancer therapy 2007 289 80 80%
Regulating the p53 pathway: in vitro hypotheses, in vivo veritas 2006 656 156 56%
p53 in health and disease 2007 917 98 27%
Small-Molecule Inhibitors of the MDM2-p53 Protein-Protein Interaction to Reactivate p53 Function: A Novel Approach for Cancer Therapy 2009 240 97 75%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 P53 23 51% 1.1% 32
2 TRANSCRIPT NETWORKS 10 52% 0.5% 14
3 GRP P53 MDM2 6 80% 0.1% 4
4 MCARDLE CANC 207A 6 100% 0.1% 4
5 STATE KAY MOL REACT DYNAM 6 100% 0.1% 4
6 CRUK SIGNAL TRANSDUCT GRP P53 5 55% 0.2% 6
7 UNIT MOL MUTAGENESIS DNA REPAIR 4 67% 0.1% 4
8 CAMBRIDGE PROT ENGN 4 27% 0.5% 14
9 CHROMOSOME STABIL GRP 4 36% 0.3% 8
10 CHROMOSOME STABIL SECT 3 37% 0.2% 7

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000287161 MUTANT P53//GAIN OF FUNCTION//CANC THER EUT S
2 0.0000164536 P53 GENE//P53 MUTANTS//MUTANT P53
3 0.0000148239 IASPP//ASPP2//53BP2
4 0.0000124227 P53 CODON 72//P53 POLYMORPHISM//CODON 72 POLYMORPHISM
5 0.0000108106 VRK1//VRK2//EXPT THER EUT TRANSLAT ONCOL PROGRAM
6 0.0000104377 P73//P63//DELTA NP73
7 0.0000074091 HIPK2//CACYBP SIP//CACYBP
8 0.0000066244 PPM1D//WIP1//CELL CYCLE CONTROL TUMORIGENESIS GRP
9 0.0000063942 PROTEOMIMETICS//ALPHA HELIX MIMETICS//HELIX MIMETICS
10 0.0000063537 SESTRIN 2//TP53INP1//SESTRIN