Class information for:
Level 1: CYP3A5//TACROLIMUS//CYTOCHROME P450 3A5

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
6438 1418 33.6 88%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
126 23061 TRANSPLANTATION//TRANSPLANTATION PROCEEDINGS//MYCOPHENOLIC ACID

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CYP3A5 Author keyword 145 58% 12% 168
2 TACROLIMUS Author keyword 84 17% 33% 462
3 CYTOCHROME P450 3A5 Author keyword 19 71% 1% 15
4 CYP3A422 Author keyword 18 83% 1% 10
5 CYP3A53 Author keyword 15 62% 1% 16
6 CYP3A41B Author keyword 14 100% 0% 7
7 TACROLIMUS PHARMACOKINETICS Author keyword 13 80% 1% 8
8 CYP3A418B Author keyword 12 86% 0% 6
9 RS35599367 Author keyword 11 100% 0% 6
10 ACMIA Author keyword 10 73% 1% 8

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 CYP3A5 145 58% 12% 168 Search CYP3A5 Search CYP3A5
2 TACROLIMUS 84 17% 33% 462 Search TACROLIMUS Search TACROLIMUS
3 CYTOCHROME P450 3A5 19 71% 1% 15 Search CYTOCHROME+P450+3A5 Search CYTOCHROME+P450+3A5
4 CYP3A422 18 83% 1% 10 Search CYP3A422 Search CYP3A422
5 CYP3A53 15 62% 1% 16 Search CYP3A53 Search CYP3A53
6 CYP3A41B 14 100% 0% 7 Search CYP3A41B Search CYP3A41B
7 TACROLIMUS PHARMACOKINETICS 13 80% 1% 8 Search TACROLIMUS+PHARMACOKINETICS Search TACROLIMUS+PHARMACOKINETICS
8 CYP3A418B 12 86% 0% 6 Search CYP3A418B Search CYP3A418B
9 RS35599367 11 100% 0% 6 Search RS35599367 Search RS35599367
10 ACMIA 10 73% 1% 8 Search ACMIA Search ACMIA

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CYP3A5 94 54% 9% 121
2 MDR1 ABCB1 POLYMORPHISMS 65 85% 2% 34
3 CYTOCHROME P4503A5 60 100% 1% 20
4 ABCB1 POLYMORPHISMS 55 67% 3% 49
5 TACROLIMUS DOSE REQUIREMENTS 51 79% 2% 33
6 CYP3A5 GENOTYPE 38 64% 3% 37
7 MICROPARTICLE ENZYME IMMUNOASSAY 32 56% 3% 39
8 APPARENT CLEARANCE 30 100% 1% 12
9 DOSE REQUIREMENTS 26 26% 6% 84
10 FK 506 ASSAY 21 75% 1% 15

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part I 2010 114 129 73%
The Role of Pharmacogenetics in the Disposition of and Response to Tacrolimus in Solid Organ Transplantation 2014 18 165 65%
Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics 2007 85 26 88%
CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy 2013 20 79 70%
Opportunities to Optimize Tacrolimus Therapy in Solid Organ Transplantation: Report of the European Consensus Conference 2009 136 104 55%
Effect of CYP3A and ABCB1 Single Nucleotide Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Calcineurin Inhibitors: Part II 2010 69 66 52%
Functional Gene Variants of CYP3A4 2014 5 69 72%
Clinical pharmacokinetics and pharmacodynamics of tacrolimus in solid organ transplantation 2004 245 270 54%
Significance of the minor cytochrome P450 3A isoforms 2006 118 115 54%
Genetic contribution to variable human CYP3A-mediated metabolism 2002 505 102 34%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 IND ENVIRONM TOXICOL UNIT 9 83% 0.4% 5
2 CARDIAC VASC SCI ANALYT UNIT 6 100% 0.3% 4
3 ABSORPT DIGEST 4 75% 0.2% 3
4 UNIDAD FARMACOGENET 4 56% 0.4% 5
5 UMR S490 3 57% 0.3% 4
6 SECT PHARMACOL P BENIGNO 3 60% 0.2% 3
7 UMR S 850 3 60% 0.2% 3
8 TOXICOL THER EUT DRUG MONITORING 2 44% 0.3% 4
9 BIOL CELULAR ENFERMEDAD RENAL 2 67% 0.1% 2
10 CHEM MEASUREMENT CALIBRAT 2 67% 0.1% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000240241 FK 506//FUJISAWA AMER//FUJISAWA AMER INC
2 0.0000175133 NEORAL//C2 MONITORING//C 2 MONITORING
3 0.0000133308 CYP3A//COCKTAIL//MECHANISM BASED INHIBITION
4 0.0000113970 P GLYCOPROTEIN//C3435T POLYMORPHISM//ABCB1
5 0.0000104232 SIROLIMUS//EVEROLIMUS//PROLIFERATION SIGNAL INHIBITORS
6 0.0000097454 RHEUMATOLOTA KU//MDR I//DANINI HOSP
7 0.0000094750 MYCOPHENOLIC ACID//MYCOPHENOLIC ACID GLUCURONIDE//MYCOPHENOLATE MOFETIL
8 0.0000092385 IMMUKNOW//IMMUNE FUNCTION ASSAY//CYLEX IMMUKNOW ASSAY
9 0.0000090084 ONCE DAILY TACROLIMUS//TACROLIMUS ONCE DAILY//SECT NEPHROL HYPERTENS TRANSPLANTAT MED
10 0.0000062060 CYCLOSPORINE G//CYCLOSPORINE METABOLITES//CYCLOSPORIN G