Class information for:
Level 1: NS5B POLYMERASE//HCV NS5B POLYMERASE//NS3 PROTEASE

Basic class information

ID Publications Average number
of references
Avg. shr. active
ref. in WoS
4782 1654 40.7 86%



Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)



ID, lev.
above
Publications Label for level above
37 32459 HEPATITIS C VIRUS//HEPATITIS C//HCV

Terms with highest relevance score



Rank Term Type of term Relevance score
(tfidf)
Class's shr.
of term's tot.
occurrences
Shr. of publ.
in class containing
term
Num. of
publ. in
class
1 NS5B POLYMERASE Author keyword 140 87% 4% 68
2 HCV NS5B POLYMERASE Author keyword 77 96% 1% 24
3 NS3 PROTEASE Author keyword 55 70% 3% 46
4 NS5B Author keyword 54 53% 4% 71
5 HCVNS5B POLYMERASE Author keyword 26 100% 1% 11
6 NS3 Author keyword 19 32% 3% 49
7 HCV NS5B POLYMERASE INHIBITORS Author keyword 18 89% 0% 8
8 NS3 4A PROTEASE Author keyword 17 68% 1% 15
9 NS3 HELICASE Author keyword 16 58% 1% 19
10 ANTIVIRAL THER Y Address 15 54% 1% 19

Web of Science journal categories

Author Key Words



Rank Web of Science journal category Relevance score
(tfidf)
Class's shr.
of term's tot.
occurrences
Shr. of publ.
in class containing
term
Num. of
publ. in
class
LCSH search Wikipedia search
1 NS5B POLYMERASE 140 87% 4% 68 Search NS5B+POLYMERASE Search NS5B+POLYMERASE
2 HCV NS5B POLYMERASE 77 96% 1% 24 Search HCV+NS5B+POLYMERASE Search HCV+NS5B+POLYMERASE
3 NS3 PROTEASE 55 70% 3% 46 Search NS3+PROTEASE Search NS3+PROTEASE
4 NS5B 54 53% 4% 71 Search NS5B Search NS5B
5 HCVNS5B POLYMERASE 26 100% 1% 11 Search HCVNS5B+POLYMERASE Search HCVNS5B+POLYMERASE
6 NS3 19 32% 3% 49 Search NS3 Search NS3
7 HCV NS5B POLYMERASE INHIBITORS 18 89% 0% 8 Search HCV+NS5B+POLYMERASE+INHIBITORS Search HCV+NS5B+POLYMERASE+INHIBITORS
8 NS3 4A PROTEASE 17 68% 1% 15 Search NS3+4A+PROTEASE Search NS3+4A+PROTEASE
9 NS3 HELICASE 16 58% 1% 19 Search NS3+HELICASE Search NS3+HELICASE
10 HCV POLYMERASE INHIBITORS 15 88% 0% 7 Search HCV+POLYMERASE+INHIBITORS Search HCV+POLYMERASE+INHIBITORS

Key Words Plus



Rank Web of Science journal category Relevance score
(tfidf)
Class's shr.
of term's tot.
occurrences
Shr. of publ.
in class containing
term
Num. of
publ. in
class
1 HCVNS5B POLYMERASE 268 87% 8% 132
2 NS4A COFACTOR PEPTIDE 116 92% 3% 46
3 NS5B POLYMERASE 110 70% 6% 91
4 DEPENDENT RNA POLYMERASE 96 23% 22% 371
5 NS4A 71 72% 3% 55
6 NS5B PROTEIN 65 90% 2% 28
7 FULL LENGTH NS3 61 95% 1% 20
8 DE NOVO INITIATION 59 49% 5% 87
9 PEPTIDE BASED INHIBITORS 56 76% 2% 39
10 ALLOSTERIC INHIBITORS 56 59% 4% 63

Journals

Reviews



Title Publ. year Cit. Active references % act. ref.
to same field
Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research 2013 12 115 97%
Challenges and successes in developing new therapies for hepatitis C 2005 296 58 59%
Hepatitis C Virus-Specific Directly Acting Antiviral Drugs 2013 18 140 49%
Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection 2009 67 48 81%
Advances in the development of new therapeutic agents targeting the NS34A serine protease or the NS5B RNA-dependent RNA polymerase of the hepatitis C virus 2007 84 115 86%
Non-nucleoside inhibitors of the HCVNS5B polymerase: Progress in the discovery and development of novel agents for the treatment of HCV infections 2007 80 74 84%
Recent progress in the development of inhibitors of the hepatitis c virus RNA-Dependent RNA polymerase 2007 76 127 78%
Recent progress in the development of selected hepatitis C virus NS3.4A protease and NS5B polymerase inhibitors 2008 87 44 70%
HCV NS5B polymerase inhibitors 2010 32 82 85%
Chutes and ladders in hepatitis C nucleoside drug development 2014 8 83 48%

Address terms



Rank Address term Relevance score
(tfidf)
Class's shr.
of term's tot.
occurrences
Shr. of publ.
in class containing
term
Num. of
publ. in
class
1 ANTIVIRAL THER Y 15 54% 1.1% 19
2 MRL ROME 7 64% 0.4% 7
3 METAB VIRAL DIS EXCELLENCE DRUG DISCOVERY 7 43% 0.7% 12
4 IST RIC BIOL MOL P ANGELETTI SPA 6 100% 0.2% 4
5 MED CHEM ORGAN PHARMACEUT CHEM 5 55% 0.4% 6
6 IRBM 5 30% 0.8% 13
7 METAB ANTIVIRAL DIS EXCELLENCE DRUG DISCOVE 3 100% 0.2% 3
8 R4CQ 3 100% 0.2% 3
9 BIOCHEM INTERDISCIPLINARY PROGRAM 2 67% 0.1% 2
10 CHEM SCREENING SCI INFECT DIS 2 50% 0.2% 3

Related classes at same level (level 1)



Rank Relatedness score Related classes
1 0.0000196739 STUDY HEPATITIS C//U748//VIROL INFECT DIS
2 0.0000137278 TELAPREVIR//RIBAVIRIN//BOCEPREVIR
3 0.0000070730 HCV GENOTYPES//INTERFERON SENSITIVITY DETERMINING REGION//HYPERVARIABLE REGION 1
4 0.0000062965 WOMEN ARTS SCI EDUC//D GAUSS//ACETATE GROUP
5 0.0000058005 OBSTET GYNECOLSEALY STRUCT BIOL//PRIMASE//HELICASE
6 0.0000053028 PRONUCLEOTIDES//PROTIDE//PRONUCLEOTIDE
7 0.0000051137 RNA HELICASE//DEAD BOX//DEAD BOX PROTEIN
8 0.0000047531 AUREOBASIDIUM SPP//BREAKTHROUGH FUNGAEMIA//METALS METALLOIDS
9 0.0000047522 3C PROTEASE//PICORNAVIRUS//PROTEINASE 3C
10 0.0000045174 IRES//INTERNAL RIBOSOME ENTRY SITE IRES//INTERNAL RIBOSOME ENTRY SITE