Class information for:
Level 1: MTHFR//FOLATE//METHYLENETETRAHYDROFOLATE REDUCTASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
3941 1802 43.0 86%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
322 17515 HOMOCYSTEINE//FOLATE//FOLIC ACID

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 MTHFR Author keyword 95 30% 15% 263
2 FOLATE Author keyword 43 11% 20% 358
3 METHYLENETETRAHYDROFOLATE REDUCTASE Author keyword 28 20% 7% 123
4 VITAMINS CARCINOGENESIS Address 14 49% 1% 21
5 MTRR Author keyword 11 40% 1% 21
6 ONE CARBON METABOLISM Author keyword 9 19% 2% 43
7 FOLATE METABOLISM Author keyword 8 23% 2% 30
8 METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR Author keyword 7 28% 1% 22
9 METHIONINE SYNTHASE REDUCTASE Author keyword 7 31% 1% 19
10 C677T Author keyword 7 28% 1% 20

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 MTHFR 95 30% 15% 263 Search MTHFR Search MTHFR
2 FOLATE 43 11% 20% 358 Search FOLATE Search FOLATE
3 METHYLENETETRAHYDROFOLATE REDUCTASE 28 20% 7% 123 Search METHYLENETETRAHYDROFOLATE+REDUCTASE Search METHYLENETETRAHYDROFOLATE+REDUCTASE
4 MTRR 11 40% 1% 21 Search MTRR Search MTRR
5 ONE CARBON METABOLISM 9 19% 2% 43 Search ONE+CARBON+METABOLISM Search ONE+CARBON+METABOLISM
6 FOLATE METABOLISM 8 23% 2% 30 Search FOLATE+METABOLISM Search FOLATE+METABOLISM
7 METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR 7 28% 1% 22 Search METHYLENETETRAHYDROFOLATE+REDUCTASE+MTHFR Search METHYLENETETRAHYDROFOLATE+REDUCTASE+MTHFR
8 METHIONINE SYNTHASE REDUCTASE 7 31% 1% 19 Search METHIONINE+SYNTHASE+REDUCTASE Search METHIONINE+SYNTHASE+REDUCTASE
9 C677T 7 28% 1% 20 Search C677T Search C677T
10 MTHFR C677T 6 23% 1% 23 Search MTHFR+C677T Search MTHFR+C677T

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 COMMON MUTATION 127 27% 23% 412
2 URACIL MISINCORPORATION 93 69% 4% 79
3 DIETARY FOLATE 84 40% 9% 164
4 A1298C POLYMORPHISMS 80 70% 4% 66
5 MTHFR POLYMORPHISMS 79 73% 3% 61
6 METHYLENETETRAHYDROFOLATE REDUCTASE POLYMORPHISM 76 52% 6% 104
7 C677T POLYMORPHISM 59 37% 7% 129
8 METHYLENETETRAHYDROFOLATE REDUCTASE MTHFR 59 45% 5% 98
9 5 10 METHYLENETETRAHYDROFOLATE REDUCTASE 55 35% 7% 127
10 PLASMA FOLATE 53 50% 4% 77

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Folate: Metabolism, genes, polymorphisms and the associated diseases 2014 24 129 69%
Vitamin B-6 and Risk of Colorectal Cancer A Meta-analysis of Prospective Studies 2010 89 29 62%
Epigenetic biomarkers of colorectal cancer: Focus on DNA methylation 2014 13 92 39%
Folate intake and the risk of colorectal cancer: A systematic review and meta-analysis 2011 55 41 68%
Folate and colorectal cancer: An evidence-based critical review 2007 158 199 49%
Higher dietary folate intake reduces the breast cancer risk: a systematic review and meta-analysis 2014 4 78 69%
Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia 2010 36 35 77%
Folate and DNA methylation: A mechanistic link between folate deficiency and colorectal cancer? 2004 177 75 65%
Meta- and Pooled Analyses of the Methylenetetrahydrofolate Reductase (MTHFR) C677T Polymorphism and Colorectal Cancer: A HuGE-GSEC Review 2009 55 70 77%
Nutrition and epigenetics: an interplay of dietary methyl donors, one-carbon metabolism and DNA methylation 2012 68 58 22%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 VITAMINS CARCINOGENESIS 14 49% 1.2% 21
2 DAY GEN HOSP 6 80% 0.2% 4
3 UNIDADE PESQUISA GENET BIOL MOL UPGEM 6 71% 0.3% 5
4 VITAMIN METAB 5 36% 0.7% 12
5 ONCOHEMATOL PEDIAT CEONHPE 4 75% 0.2% 3
6 UPGEM 4 56% 0.3% 5
7 VITAMIN CARCINOGENESIS 3 100% 0.2% 3
8 NUTR EPIGENET GRP 3 33% 0.4% 7
9 GENET MOL BIOL UNIT UPGEM 2 44% 0.2% 4
10 BIOCHEM DIETET 2 67% 0.1% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000115941 FOOD FOLATE//FOLATE BIOAVAILABILITY//FOLATES
2 0.0000114751 NEURAL TUBE DEFECTS//FOLIC ACID//ANENCEPHALY
3 0.0000098875 THYMIDYLATE SYNTHASE//DIHYDROPYRIMIDINE DEHYDROGENASE//OROTATE PHOSPHORIBOSYL TRANSFERASE
4 0.0000095983 HOMOCYSTEINE//HYPERHOMOCYSTEINEMIA//FOLATE
5 0.0000087712 MIR 1260B//NOUVEL HOP ESTAING//DIETARY COMPOUNDS
6 0.0000081431 CHOLINE DEFICIENCY//BETAINE//CHOLINE
7 0.0000076456 COLORECTAL ADENOMA//COLORECTAL ADENOMAS//RED MEAT
8 0.0000061210 SERINE HYDROXYMETHYLTRANSFERASE//THREONINE ALDOLASE//BIOCATALYT CHEM
9 0.0000058618 THROMBOPHILIA//RECURRENT PREGNANCY LOSS//FACTOR V LEIDEN
10 0.0000055130 ARIZONA PUBL HLTH//CERVICAL NEOPLASIA RISK//GENITAL HPV