Class information for:
Level 1: THIOPURINE METHYLTRANSFERASE//6 MERCAPTOPURINE//THIOPURINE S METHYLTRANSFERASE

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
3654 1859 34.3 75%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
3031 2012 THIOPURINE METHYLTRANSFERASE//6 MERCAPTOPURINE//THIOPURINE S METHYLTRANSFERASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 THIOPURINE METHYLTRANSFERASE Author keyword 332 90% 8% 144
2 6 MERCAPTOPURINE Author keyword 203 53% 15% 271
3 THIOPURINE S METHYLTRANSFERASE Author keyword 190 89% 5% 87
4 AZATHIOPRINE Author keyword 141 30% 22% 401
5 TPMT Author keyword 126 79% 4% 80
6 6 THIOGUANINE NUCLEOTIDES Author keyword 87 94% 2% 31
7 THIOPURINE Author keyword 50 61% 3% 53
8 THIOPURINES Author keyword 48 48% 4% 73
9 6 THIOGUANINE Author keyword 48 47% 4% 76
10 MERCAPTOPURINE Author keyword 47 54% 3% 61

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 THIOPURINE METHYLTRANSFERASE 332 90% 8% 144 Search THIOPURINE+METHYLTRANSFERASE Search THIOPURINE+METHYLTRANSFERASE
2 6 MERCAPTOPURINE 203 53% 15% 271 Search 6+MERCAPTOPURINE Search 6+MERCAPTOPURINE
3 THIOPURINE S METHYLTRANSFERASE 190 89% 5% 87 Search THIOPURINE+S+METHYLTRANSFERASE Search THIOPURINE+S+METHYLTRANSFERASE
4 AZATHIOPRINE 141 30% 22% 401 Search AZATHIOPRINE Search AZATHIOPRINE
5 TPMT 126 79% 4% 80 Search TPMT Search TPMT
6 6 THIOGUANINE NUCLEOTIDES 87 94% 2% 31 Search 6+THIOGUANINE+NUCLEOTIDES Search 6+THIOGUANINE+NUCLEOTIDES
7 THIOPURINE 50 61% 3% 53 Search THIOPURINE Search THIOPURINE
8 THIOPURINES 48 48% 4% 73 Search THIOPURINES Search THIOPURINES
9 6 THIOGUANINE 48 47% 4% 76 Search 6+THIOGUANINE Search 6+THIOGUANINE
10 MERCAPTOPURINE 47 54% 3% 61 Search MERCAPTOPURINE Search MERCAPTOPURINE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 6 MERCAPTOPURINE 296 41% 30% 553
2 MERCAPTOPURINE 253 70% 11% 209
3 S METHYLTRANSFERASE 212 76% 8% 151
4 6 THIOGUANINE NUCLEOTIDE 155 95% 3% 53
5 MERCAPTOPURINE METABOLISM 141 83% 4% 79
6 AZATHIOPRINE THERAPY 135 65% 7% 130
7 ERYTHROCYTE CORRELATION 115 100% 2% 33
8 6 THIOGUANINE 115 57% 7% 135
9 AZATHIOPRINE INDUCED MYELOSUPPRESSION 104 90% 2% 45
10 6 MERCAPTOPURINE THERAPY 97 85% 3% 51

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Review article: the benefits of pharmacogenetics for improving thiopurine therapy in inflammatory bowel disease 2012 47 205 85%
Update 2014: Advances to Optimize 6-Mercaptopurine and Azathioprine to Reduce Toxicity and Improve Efficacy in the Management of IBD 2015 1 78 86%
Getting the best out of thiopurine therapy: thiopurine S-methyltransferase and beyond 2015 1 103 83%
Clinical pharmacology and pharmacogenetics of thiopurines 2008 119 125 81%
Nomenclature for alleles of the thiopurine methyltransferase gene 2013 20 46 91%
Thiopurine-induced myelotoxicity in patients with inflammatory bowel disease: A review 2008 62 124 91%
Genetic polymorphism of thiopurine methyltransferase and its clinical relevance for childhood acute lymphoblastic leukemia 2000 222 30 100%
Assessment of Thiopurine S-Methyltransferase Activity in Patients Prescribed Thiopurines: A Systematic Review 2011 30 71 92%
Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease 2005 99 48 96%
AZATHIOPRINE AND 6-MERCAPTOPURINE IN CROHN DISEASE - A METAANALYSIS 1995 510 19 53%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 UNIDAD TOXICOL MOL HEPAT 15 77% 0.5% 10
2 PURINE 8 27% 1.3% 24
3 PEDIAT ONCOL SE NETHERLANDS 6 100% 0.2% 4
4 HAEMATOL ONCOL OUTPATIENT 4 75% 0.2% 3
5 CLIN SCI CSUH 2 67% 0.1% 2
6 UMR S 1147 2 67% 0.1% 2
7 UNIT MOL CLIN PHARMACOL 2 67% 0.1% 2
8 UNITE PHARMACOL PEDIAT 2 67% 0.1% 2
9 SECT MED PHARMACOL 2 33% 0.3% 5
10 GYNECOL OBSTET PEDIAT 2 17% 0.5% 9

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000120353 CHROMOSOME 5 ABNORMALITY//PHARM NTHC NARILIS//UNIDAD HEMATOL CLIN
2 0.0000103516 INFLIXIMAB//VEDOLIZUMAB//ADALIMUMAB
3 0.0000096995 SEVERE ULCERATIVE COLITIS//TOXIC MEGACOLON//STEROID REFRACTORY ULCERATIVE COLITIS
4 0.0000076401 IDIOPATHIC PORTAL HYPERTENSION//NODULAR REGENERATIVE HYPERPLASIA//HEPATOPORTAL SCLEROSIS
5 0.0000073441 MESALAZINE//5 AMINOSALICYLIC ACID//MESALAMINE
6 0.0000067004 PHARMACOGENOMICS//PERSONALIZED MEDICINE//PROGRAM PERSONALIZED MED TARGETED THER EUT
7 0.0000055640 ENDONUCLEASE V//S CAROLINA EXPT STN//OXANINE
8 0.0000051064 4 THIOTHYMIDINE//THIOTHYMIDINE//NITROSAMINE INDUCED CANC GRP
9 0.0000034045 METHOTREXATE//METHOTREXATE POLYGLUTAMATES//MX 68
10 0.0000034045 ACUTE LYMPHOBLASTIC LEUKEMIA//MINIMAL RESIDUAL DISEASE//ACUTE LYMPHOBLASTIC LEUKAEMIA