Class information for:
Level 1: P110 ALPHA//PIK3CA//PI3K ALPHA

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
2886 2047 48.7 93%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
625 13166 PTEN//MTOR//LHERMITTE DUCLOS DISEASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 P110 ALPHA Author keyword 70 89% 2% 32
2 PIK3CA Author keyword 48 33% 6% 118
3 PI3K ALPHA Author keyword 38 86% 1% 19
4 PI3K GAMMA Author keyword 37 73% 1% 29
5 PI3K Author keyword 33 12% 12% 250
6 PI3K INHIBITOR Author keyword 24 52% 2% 33
7 P110 DELTA Author keyword 24 82% 1% 14
8 P110 BETA Author keyword 19 76% 1% 13
9 ZSTK474 Author keyword 19 76% 1% 13
10 PI3K INHIBITORS Author keyword 18 58% 1% 21

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 P110 ALPHA 70 89% 2% 32 Search P110+ALPHA Search P110+ALPHA
2 PIK3CA 48 33% 6% 118 Search PIK3CA Search PIK3CA
3 PI3K ALPHA 38 86% 1% 19 Search PI3K+ALPHA Search PI3K+ALPHA
4 PI3K GAMMA 37 73% 1% 29 Search PI3K+GAMMA Search PI3K+GAMMA
5 PI3K 33 12% 12% 250 Search PI3K Search PI3K
6 PI3K INHIBITOR 24 52% 2% 33 Search PI3K+INHIBITOR Search PI3K+INHIBITOR
7 P110 DELTA 24 82% 1% 14 Search P110+DELTA Search P110+DELTA
8 P110 BETA 19 76% 1% 13 Search P110+BETA Search P110+BETA
9 ZSTK474 19 76% 1% 13 Search ZSTK474 Search ZSTK474
10 PI3K INHIBITORS 18 58% 1% 21 Search PI3K+INHIBITORS Search PI3K+INHIBITORS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 P110 ALPHA 107 76% 4% 74
2 P110 DELTA 100 73% 4% 76
3 PI3K 86 44% 7% 147
4 PIK3CA GENE 80 45% 6% 132
5 PI3K GAMMA 66 55% 4% 82
6 P110 GAMMA 50 84% 1% 27
7 PHOSPHOINOSITIDE 3 KINASE 49 10% 22% 448
8 PI3K GAMMA INHIBITION 45 90% 1% 19
9 PHOSPHOINOSITIDE 3 KINASE P110 DELTA 44 77% 1% 30
10 P85 REGULATORY SUBUNIT 42 69% 2% 36

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting 2015 9 195 68%
PI3K and cancer: lessons, challenges and opportunities 2014 149 215 29%
Targeting PI3 kinase in cancer 2015 9 56 52%
Development of PI3K inhibitors: lessons learned from early clinical trials 2013 151 72 43%
The PI3K Pathway As Drug Target in Human Cancer 2010 435 98 51%
Targeting PI3K signalling in cancer: opportunities, challenges and limitations 2009 875 150 41%
Targeting the phosphoinositide 3-kinase pathway in cancer 2009 779 195 45%
The emerging mechanisms of isoform-specific PI3K signalling 2010 377 166 50%
Picking the Point of Inhibition: A Comparative Review of PI3K/AKT/mTOR Pathway Inhibitors 2014 35 51 59%
PI3K pathway alterations in cancer: variations on a theme 2008 643 83 47%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 HIGH THROUGHPUT SCREENING MOL PHARMACOL 11 78% 0.3% 7
2 LYMPHOCYTE SIGNALLING DEV 7 21% 1.4% 29
3 CANC METAB BIOL 6 100% 0.2% 4
4 CANC METAB CHEM 6 100% 0.2% 4
5 CANC METAB DMPK 6 100% 0.2% 4
6 STRUCT BIOL MOL MODELING 4 75% 0.1% 3
7 ONCOL DIS AREA 4 32% 0.5% 10
8 ORIGINAL NEW DRUGS DESIGN DISCOVERY 3 39% 0.3% 7
9 SMALL MOL TRANSLAT ONCOL 3 100% 0.1% 3
10 INOSITIDE SIGNALLING GRP 3 40% 0.3% 6

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000257388 BIOL CHEMBUNKYO KU//DEMETHOXYVIRIDIN//2 4 MORPHOLINYL 8 PHENYLCHROMONE
2 0.0000164790 PDK1//AKT ISOFORMS//AKT2
3 0.0000118986 MTOR//RAPAMYCIN//CCI 779
4 0.0000090450 PTEN//LHERMITTE DUCLOS DISEASE//COWDEN SYNDROME
5 0.0000084694 SHIP2//INOSITOL 5 PHOSPHATASE//SHIP1
6 0.0000067862 PIKFYVE//PTDINS5P//GOLPH3
7 0.0000054946 CHEMOTAXIS SIGNAL SECT//GRADIENT SENSING//DIRECTIONAL SENSING
8 0.0000046202 C PEPTICLE//CLIN PHYSIOL METAB UNIT//HENRY WELLCOME S EGRATED CELL SIGNALLING
9 0.0000042086 HALENAQUINONE//PERHYDROPHENANTHRENES//XESTOQUINONE
10 0.0000041923 INSULIN RECEPTOR SUBSTRATE//INSULIN RECEPTOR SUBSTRATE 1//IRS 1