Class information for:
Level 1: PROXIMITY ORIENTATION//CYCLIC PRODRUG//ESTERASE SENSITIVE PRODRUGS

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
23274 297 34.4 50%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1038 9652 GRUNWALD WINSTEIN EQUATION//PYRIDINOLYSIS//CROSS INTERACTION CONSTANT

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 PROXIMITY ORIENTATION Author keyword 14 100% 2% 7
2 CYCLIC PRODRUG Author keyword 9 83% 2% 5
3 ESTERASE SENSITIVE PRODRUGS Author keyword 8 100% 2% 5
4 EFFECTIVE MOLARITY EM Author keyword 6 100% 1% 4
5 ESTERASE SENSITIVE PRODRUG Author keyword 6 100% 1% 4
6 KIRBYS ENZYME MODEL Author keyword 6 100% 1% 4
7 CHEMICAL AND ENZYMATIC STABILITY Author keyword 4 67% 1% 4
8 KIRBYS ENZYME MODELS Author keyword 3 100% 1% 3
9 OPIOID PEPTIDE DELIVERY Author keyword 2 67% 1% 2
10 TRANSCELLULAR DIFFUSION Author keyword 2 67% 1% 2

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class		 LCSH search Wikipedia search
1 PROXIMITY ORIENTATION 14 100% 2% 7 Search PROXIMITY+ORIENTATION Search PROXIMITY+ORIENTATION
2 CYCLIC PRODRUG 9 83% 2% 5 Search CYCLIC+PRODRUG Search CYCLIC+PRODRUG
3 ESTERASE SENSITIVE PRODRUGS 8 100% 2% 5 Search ESTERASE+SENSITIVE+PRODRUGS Search ESTERASE+SENSITIVE+PRODRUGS
4 EFFECTIVE MOLARITY EM 6 100% 1% 4 Search EFFECTIVE+MOLARITY+EM Search EFFECTIVE+MOLARITY+EM
5 ESTERASE SENSITIVE PRODRUG 6 100% 1% 4 Search ESTERASE+SENSITIVE+PRODRUG Search ESTERASE+SENSITIVE+PRODRUG
6 KIRBYS ENZYME MODEL 6 100% 1% 4 Search KIRBYS+ENZYME+MODEL Search KIRBYS+ENZYME+MODEL
7 CHEMICAL AND ENZYMATIC STABILITY 4 67% 1% 4 Search CHEMICAL+AND+ENZYMATIC+STABILITY Search CHEMICAL+AND+ENZYMATIC+STABILITY
8 KIRBYS ENZYME MODELS 3 100% 1% 3 Search KIRBYS+ENZYME+MODELS Search KIRBYS+ENZYME+MODELS
9 OPIOID PEPTIDE DELIVERY 2 67% 1% 2 Search OPIOID+PEPTIDE+DELIVERY Search OPIOID+PEPTIDE+DELIVERY
10 TRANSCELLULAR DIFFUSION 2 67% 1% 2 Search TRANSCELLULAR+DIFFUSION Search TRANSCELLULAR+DIFFUSION

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 COUMARINIC ACID 30 100% 4% 12
2 STEREOPOPULATION CONTROL 29 52% 13% 39
3 AMINE PRODRUGS 21 78% 5% 14
4 MONOPHENYL ESTERS 21 78% 5% 14
5 ALIPHATIC AMIDE 21 90% 3% 9
6 HYDROXY AMIDE LACTONIZATION 20 66% 6% 19
7 EFFECTIVE MOLARITY EM 20 100% 3% 9
8 ETHER HYDROLYSIS 18 89% 3% 8
9 CYCLIC ANHYDRIDE FORMATION 16 56% 6% 19
10 KIRBYS ENZYME MODEL 15 88% 2% 7

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Cyclization-activated prodrugs 2007 30 84 33%
Prodrug strategies based on intramolecular cyclization reactions 1997 63 28 54%
Ground state and transition state contributions to the rates of intramolecular and enzymatic reactions 1999 175 30 20%
Efficiency of proton transfer catalysis in models and enzymes 1997 114 16 31%
ENZYME REACTIVITY FROM AN ORGANIC PERSPECTIVE 1993 89 15 27%
The future of prodrugs - design by quantum mechanics methods 2013 0 71 49%
Design of intramolecularly activated prodrugs 1998 20 21 33%
Drug targeting to hypoxic tissue using self-inactivating bioreductive delivery systems 2001 8 13 31%
ON THE SOURCE OF INTRAMOLECULAR AND ENZYMATIC REACTIVITY 1985 280 12 50%
Prodrugs Design Based on Inter- and Intramolecular Chemical Processes 2013 0 138 33%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 BIOORGAN PHARMACEUT CHEM 1 100% 0.7% 2
2 ORGAN CHEM BIOMAT POLYMER GRP 1 50% 0.3% 1
3 SIMONS S 1 12% 1.7% 5
4 AGR FO TRY ENVIRONM 0 20% 0.7% 2
5 EUROPEAN CULTU DICEM 0 17% 0.3% 1
6 STUDIO MECCANISMI REAZIONE 0 10% 0.3% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000135004 DIFFUSION CELL EXPERIMENTS//TRANSFORMED POTTS GUY EQUATION//ROBERTS SLOAN EQUATION
2 0.0000133426 HALOCARBANIONS//ARGININE CARBOXYLATE INTERACTIONS//AZIRIDINIUM CATION
3 0.0000128223 ALPHA AMINOAMIDE//ALPHA AMINOESTER//L ENANTIOSPECIFIC HYDROLYSIS
4 0.0000126592 SELF IMMOLATIVE//POLYMETHYL GLYOXYLATE//BIOMED SCI PROGRAMS
5 0.0000112029 3S 5R 6R 6 ACETYLAMIDOPENICILLANIC ACID//BETA LACTAM COMPOUNDS//PIPER LOLOT
6 0.0000109724 GEM DIMETHYL EFFECT//BISTRIFLUOROMETHYLAMINO OXYL//DEDIAZOTATION
7 0.0000093301 CACO 2//SINGLE PASS INTESTINAL PERFUSION//INTESTINAL PERFUSION
8 0.0000081760 PYRIDINOLYSIS//CROSS INTERACTION CONSTANT//BRONSTED TYPE PLOT
9 0.0000078142 BIOTECH DRUG DESIGN//HGEBIET ORGAN CHEM//CPR ANALYT
10 0.0000069969 POTENTIAL ENERGY SURFACE AB INITIO CALCULATIONS//GEM DITHIOLS//KINETIC IR SPECTROSCOPY