Class information for:
Level 1: REDUCED FOLATE CARRIER//FOLYLPOLYGLUTAMATE SYNTHETASE//HEREDITARY FOLATE MALABSORPTION

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
2239 2239 34.7 63%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1587 6631 FOLATE RECEPTOR//REDUCED FOLATE CARRIER//DIHYDROFOLATE REDUCTASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 REDUCED FOLATE CARRIER Author keyword 83 63% 4% 83
2 FOLYLPOLYGLUTAMATE SYNTHETASE Author keyword 63 76% 2% 44
3 HEREDITARY FOLATE MALABSORPTION Author keyword 41 100% 1% 15
4 PCFT Author keyword 38 84% 1% 21
5 PROTON COUPLED FOLATE TRANSPORTER Author keyword 31 73% 1% 24
6 EDATREXATE Author keyword 27 72% 1% 21
7 POLYGLUTAMATION Author keyword 25 77% 1% 17
8 EXPT CLIN THER EUT PROGRAM Address 24 57% 1% 28
9 FOLATE TRANSPORT Author keyword 23 65% 1% 22
10 ANTIFOLATES Author keyword 21 35% 2% 50

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 REDUCED FOLATE CARRIER 83 63% 4% 83 Search REDUCED+FOLATE+CARRIER Search REDUCED+FOLATE+CARRIER
2 FOLYLPOLYGLUTAMATE SYNTHETASE 63 76% 2% 44 Search FOLYLPOLYGLUTAMATE+SYNTHETASE Search FOLYLPOLYGLUTAMATE+SYNTHETASE
3 HEREDITARY FOLATE MALABSORPTION 41 100% 1% 15 Search HEREDITARY+FOLATE+MALABSORPTION Search HEREDITARY+FOLATE+MALABSORPTION
4 PCFT 38 84% 1% 21 Search PCFT Search PCFT
5 PROTON COUPLED FOLATE TRANSPORTER 31 73% 1% 24 Search PROTON+COUPLED+FOLATE+TRANSPORTER Search PROTON+COUPLED+FOLATE+TRANSPORTER
6 EDATREXATE 27 72% 1% 21 Search EDATREXATE Search EDATREXATE
7 POLYGLUTAMATION 25 77% 1% 17 Search POLYGLUTAMATION Search POLYGLUTAMATION
8 FOLATE TRANSPORT 23 65% 1% 22 Search FOLATE+TRANSPORT Search FOLATE+TRANSPORT
9 ANTIFOLATES 21 35% 2% 50 Search ANTIFOLATES Search ANTIFOLATES
10 ANTIFOLATE 20 31% 3% 56 Search ANTIFOLATE Search ANTIFOLATE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DENOVO PURINE SYNTHESIS 112 85% 3% 60
2 FOLATE ANALOGS 107 77% 3% 72
3 GLYCINAMIDE RIBONUCLEOTIDE FORMYLTRANSFERASE 85 85% 2% 45
4 GAMMA GLUTAMATE SYNTHETASE 75 62% 3% 78
5 N 10 PROPARGYL 5 8 DIDEAZAFOLIC ACID 73 85% 2% 39
6 TRANSPORT DEFICIENT 69 93% 1% 26
7 CB3717 66 83% 2% 38
8 5 10 DIDEAZA 5 6 7 8 TETRAHYDROFOLATE 64 82% 2% 37
9 FOLYLPOLYGLUTAMATE SYNTHETASE ACTIVITY 62 85% 1% 33
10 10 DEAZA AMINOPTERIN SERIES 55 77% 2% 37

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistance 2012 50 359 62%
Carrier-mediated membrane transport of folates in mammalian cells 1999 192 90 79%
Anticancer antifolates: Current status and future directions. 2003 167 175 78%
Mechanisms of Membrane Transport of Folates into Cells and Across Epithelia 2011 56 151 50%
Membrane transport of folates 2003 212 235 58%
Molecular basis of antifolate resistance 2007 123 216 66%
Folate and thiamine transporters mediated by facilitative carriers (SLC19A1-3 and SLC46A1) and folate receptors 2013 20 96 45%
Resistance to antifolates 2003 132 305 64%
Human reduced folate carrier: translation of basic biology to cancer etiology and therapy 2007 75 142 73%
Pemetrexed: biochemical and cellular pharmacology, mechanisms, and clinical applications 2007 101 103 55%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 EXPT CLIN THER EUT PROGRAM 24 57% 1.3% 28
2 PROGRAM MOL PHARMACOL EXPT THER EUT 9 47% 0.7% 15
3 FRED WYSZKOWSKI CANC 5 28% 0.7% 15
4 GRACE CANC DRUG 3 12% 1.0% 23
5 PENNY COLE HEMATOL 3 60% 0.1% 3
6 ALBERT E EIN COMPREHENS CANC 3 20% 0.5% 12
7 GRACE CANC DRUG EXPTL THER EUT 1 100% 0.1% 2
8 PHARMACEUT BUSINESS DEV 1 50% 0.1% 2
9 TAKEDA RABICS 1 100% 0.1% 2
10 MOL THER EUT PROGRAM 1 10% 0.5% 12

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000168222 FOLATE RECEPTOR//FOLATE BINDING PROTEIN//FOLATE RECEPTOR ALPHA
2 0.0000162686 HPPK//DIHYDROPTEROATE SYNTHASE//PYROPHOSPHOKINASE
3 0.0000159349 7 HYDROXYMETHOTREXATE//GLUCARPIDASE//HIGH DOSE METHOTREXATE
4 0.0000149250 THYMIDYLATE SYNTHASE//THYX//DEOXYTUBULOSINE
5 0.0000101042 SERINE HYDROXYMETHYLTRANSFERASE//THREONINE ALDOLASE//BIOCATALYT CHEM
6 0.0000088192 FOOD FOLATE//FOLATE BIOAVAILABILITY//FOLATES
7 0.0000068121 DIHYDROFOLATE REDUCTASE//HYDROGEN TUNNELING//PROMOTING VIBRATION
8 0.0000064826 PEMETREXED//MULTITARGETED ANTIFOLATE//NONSQUAMOUS
9 0.0000060014 METHOTREXATE//METHOTREXATE POLYGLUTAMATES//MX 68
10 0.0000058308 INTESTINAL DAMAGE//SOYBEAN CONCENTRATE//ADJUVANT FREUND INDUCED ARTHRITIS