Class information for:
Level 1: GENOTOXIC IMPURITIES//VIRACEPT//ANALYTICAL CONTROL STRATEGY

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
21098 373 31.4 55%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1613 6524 TOXICOGENOMICS//BENCHMARK DOSE//GENOTOXIC IMPURITIES

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 GENOTOXIC IMPURITIES Author keyword 41 68% 10% 36
2 VIRACEPT Author keyword 12 86% 2% 6
3 ANALYTICAL CONTROL STRATEGY Author keyword 4 75% 1% 3
4 NELFINAVIR MESILATE Author keyword 4 75% 1% 3
5 CHICAGO PHARMACEUT SCI GRP Address 3 100% 1% 3
6 NOGEL Author keyword 3 100% 1% 3
7 DRUG DISPOSIT PRECLIN SAFETY ANIM Address 2 67% 1% 2
8 GENETIC SAFETY Author keyword 2 67% 1% 2
9 MUTATION THRESHOLD Author keyword 2 67% 1% 2
10 VITRY ALFORTVILLE Address 2 40% 1% 4

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 GENOTOXIC IMPURITIES 41 68% 10% 36 Search GENOTOXIC+IMPURITIES Search GENOTOXIC+IMPURITIES
2 VIRACEPT 12 86% 2% 6 Search VIRACEPT Search VIRACEPT
3 ANALYTICAL CONTROL STRATEGY 4 75% 1% 3 Search ANALYTICAL+CONTROL+STRATEGY Search ANALYTICAL+CONTROL+STRATEGY
4 NELFINAVIR MESILATE 4 75% 1% 3 Search NELFINAVIR+MESILATE Search NELFINAVIR+MESILATE
5 NOGEL 3 100% 1% 3 Search NOGEL Search NOGEL
6 GENETIC SAFETY 2 67% 1% 2 Search GENETIC+SAFETY Search GENETIC+SAFETY
7 MUTATION THRESHOLD 2 67% 1% 2 Search MUTATION+THRESHOLD Search MUTATION+THRESHOLD
8 SULFONATE ESTERS 2 29% 1% 5 Search SULFONATE+ESTERS Search SULFONATE+ESTERS
9 1 3 DIISOPROPYLUREA 1 100% 1% 2 Search 1+3+DIISOPROPYLUREA Search 1+3+DIISOPROPYLUREA
10 4 CHLORO 1 BUTANOL 1 100% 1% 2 Search 4+CHLORO+1+BUTANOL Search 4+CHLORO+1+BUTANOL

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 GENOTOXIC IMPURITIES 15 73% 3% 11
2 INGREDIENTS APIS 11 100% 2% 6
3 DRUG SUBSTANCES 8 27% 7% 25
4 POTENTIAL GENOTOXIC IMPURITIES 3 100% 1% 3
5 GC MS METHOD 3 35% 2% 7
6 THRESHOLD MEDIATED MECHANISMS 3 60% 1% 3
7 ETHYL METHANESULFONATE 2 10% 5% 20
8 METHANESULFONIC ACID ESTERS 2 67% 1% 2
9 1 3 DIISOPROPYLUREA 1 50% 1% 2
10 PHARMACEUTICAL INGREDIENTS APIS 1 100% 1% 2

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Strategies for the identification, control and determination of genotoxic impurities in drug substances: A pharmaceutical industry perspective 2011 23 36 69%
Control of Genotoxic Impurities in Active Pharmaceutical Ingredients: A Review and Perspective 2010 42 41 54%
Control and analysis of alkyl esters of alkyl and aryl sulfonic acids in novel active pharmaceutical ingredients (APIs) 2008 39 10 90%
Toxicological overview of impurities in pharmaceutical products 2007 37 2 100%
Recent advances in trace analysis of pharmaceutical genotoxic impurities 2010 39 69 36%
A Systematic Method Development Strategy for Determination of Pharmaceutical Genotoxic Impurities 2010 14 19 63%
Potential thresholds for genotoxic effects by micronucleus scoring 2011 15 38 42%
Assessment of mechanisms driving non-linear dose-response relationships in genotoxicity testing 2015 1 175 14%
Review of Quality Deficiencies Found in Active Phamaceutical Ingredient Master Files Submitted to the WHO Prequalification of Medicines Programme 2014 0 1 100%
Control and analysis of alkyl and benzyl halides and other related reactive organohalides as potential genotoxic impurities in active pharmaceutical ingredients (APIs) 2008 37 24 38%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 CHICAGO PHARMACEUT SCI GRP 3 100% 0.8% 3
2 DRUG DISPOSIT PRECLIN SAFETY ANIM 2 67% 0.5% 2
3 VITRY ALFORTVILLE 2 40% 1.1% 4
4 ESTABLISHED PHARMACEUT 1 50% 0.5% 2
5 PHARM SCI TECH 1 100% 0.5% 2
6 R45T 1 100% 0.5% 2
7 US I PROC DEV 1 100% 0.5% 2
8 PULM ALLERGY PROD 1 33% 0.5% 2
9 ANALYT QUAL SERV 1 50% 0.3% 1
10 BUNDES ARZNEIMITTEL MED PROD BFARM 1 50% 0.3% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000242276 THRESHOLD OF TOXICOLOGICAL CONCERN//THRESHOLD OF TOXICOLOGICAL CONCERN TTC//EXPOSURE BASED WAIVING
2 0.0000155602 MOUSE LYMPHOMA ASSAY//DGRT//L5178Y MOUSE LYMPHOMA CELL
3 0.0000136615 TD50//MC4PC//RODENT CARCINOGENICITY BIOASSAY
4 0.0000126968 LIVER MICRONUCLEUS ASSAY//CD71 ANTIGEN//IWGT
5 0.0000077321 LACI//MUTA TM MOUSE//LACL
6 0.0000074316 DIBROMANTIN//1 3 DIBROMO 5 5 DIMETHYL 2 4 IMIDAZOLIDINEDIONE 77 48 5//BETA KETO CARBONYL COMPOUNDS
7 0.0000072682 ETHYLENE OXIDE//HEMOGLOBIN ADDUCTS//HYDROXYETHYLVALINE
8 0.0000068391 MICRONUCLEI//MICRONUCLEUS//BUCCAL MUCOSA CELLS
9 0.0000061776 ORGANIC SOLVENT NANOFILTRATION//SOLVENT RESISTANT NANOFILTRATION//ORGANIC SOLVENT NANOFILTRATION OSN
10 0.0000059772 BENCHMARK DOSE//INTRALITTER CORRELATION//EXCHANGEABLE BINARY DATA