Class information for:
Level 1: NRF2//KEAP1//ANTIOXIDANT RESPONSE ELEMENT

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
2102 2289 52.3 93%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1589 6607 SULFORAPHANE//GLUCOSINOLATES//NRF2

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 NRF2 Author keyword 451 44% 34% 779
2 KEAP1 Author keyword 235 74% 8% 173
3 ANTIOXIDANT RESPONSE ELEMENT Author keyword 76 53% 4% 101
4 KELCH LIKE ECH ASSOCIATED PROTEIN 1 KEAP1 Author keyword 24 82% 1% 14
5 ARE Author keyword 24 38% 2% 50
6 NF E2 RELATED FACTOR 2 Author keyword 23 41% 2% 44
7 ANTIOXIDANT RESPONSIVE ELEMENT Author keyword 22 60% 1% 24
8 ENVIRONM PONSE PROJECT Address 22 58% 1% 25
9 NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 Author keyword 18 34% 2% 44
10 INRF2 KEAP1 Author keyword 14 100% 0% 7

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 NRF2 451 44% 34% 779 Search NRF2 Search NRF2
2 KEAP1 235 74% 8% 173 Search KEAP1 Search KEAP1
3 ANTIOXIDANT RESPONSE ELEMENT 76 53% 4% 101 Search ANTIOXIDANT+RESPONSE+ELEMENT Search ANTIOXIDANT+RESPONSE+ELEMENT
4 KELCH LIKE ECH ASSOCIATED PROTEIN 1 KEAP1 24 82% 1% 14 Search KELCH+LIKE+ECH+ASSOCIATED+PROTEIN+1+KEAP1 Search KELCH+LIKE+ECH+ASSOCIATED+PROTEIN+1+KEAP1
5 ARE 24 38% 2% 50 Search ARE Search ARE
6 NF E2 RELATED FACTOR 2 23 41% 2% 44 Search NF+E2+RELATED+FACTOR+2 Search NF+E2+RELATED+FACTOR+2
7 ANTIOXIDANT RESPONSIVE ELEMENT 22 60% 1% 24 Search ANTIOXIDANT+RESPONSIVE+ELEMENT Search ANTIOXIDANT+RESPONSIVE+ELEMENT
8 NUCLEAR FACTOR ERYTHROID 2 RELATED FACTOR 2 18 34% 2% 44 Search NUCLEAR+FACTOR+ERYTHROID+2+RELATED+FACTOR+2 Search NUCLEAR+FACTOR+ERYTHROID+2+RELATED+FACTOR+2
9 INRF2 KEAP1 14 100% 0% 7 Search INRF2+KEAP1 Search INRF2+KEAP1
10 NRF2 ARE 11 65% 0% 11 Search NRF2+ARE Search NRF2+ARE

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 TRANSCRIPTION FACTOR NRF2 452 56% 24% 550
2 ANTIOXIDANT RESPONSE ELEMENT 274 49% 18% 410
3 CUL3 BASED E3 LIGASE 206 75% 6% 147
4 NF E2 RELATED FACTOR 2 166 71% 6% 135
5 KEAP1 146 61% 7% 157
6 NRF2 120 31% 14% 319
7 SUBSTRATE ADAPTER PROTEIN 99 88% 2% 46
8 ANTIOXIDANT RESPONSE 96 46% 7% 155
9 KEAP1 NRF2 PATHWAY 58 72% 2% 46
10 YA SUBUNIT GENE 55 39% 5% 110

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism 2014 62 171 68%
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway 2007 942 106 72%
Role of Nrf2 in Oxidative Stress and Toxicity 2013 159 186 64%
Regulation of Nrf2-an update 2014 58 114 64%
The Nrf2-Antioxidant Response Element Signaling Pathway and Its Activation by Oxidative Stress 2009 463 49 92%
Molecular mechanisms of the Keap1-Nrf2 pathway in stress response and cancer evolution 2011 241 103 75%
Toward clinical application of the Keap1-Nrf2 pathway 2013 71 52 83%
The Keap1-Nrf2 pathway: Mechanisms of activation and dysregulation in cancer 2013 68 15 80%
The emerging role of the Nrf2-Keap1 signaling pathway in cancer 2013 71 132 77%
Nrf2:INrf2 (Keap1) signaling in oxidative stress 2009 354 96 78%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 ENVIRONM PONSE PROJECT 22 58% 1.1% 25
2 RADIOISOTOPE SCI 12 58% 0.6% 14
3 ST S PONSE SCI 12 50% 0.7% 17
4 BIOSCI DRUG DISCOVERY 11 100% 0.3% 6
5 JACQUI WOOD CANC 6 31% 0.7% 17
6 WELF ENGN 6 26% 0.8% 19
7 LEWIS B DOROTHY CULLMAN CANC CHEMOPROTECT 5 35% 0.5% 12
8 HLTH EFFECTS DIS CONTROL PREVENT 5 43% 0.4% 9
9 EXPLORATORY ADV TECHNOL ENVIRONM PONSE PRO 5 63% 0.2% 5
10 MAJOR SUBJECT ENVIRONM HLTH FUJIAN KEY UNIV 5 63% 0.2% 5

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000125183 SULFORAPHANE//PHENETHYL ISOTHIOCYANATE//ISOTHIOCYANATES
2 0.0000102934 NITRO FATTY ACIDS//NITRATED FATTY ACIDS//NITRATED LIPIDS
3 0.0000092450 OLTIPRAZ//1 2 DITHIOLE 3 THIONES//1 2 DITHIOLE 3 THIONE
4 0.0000088443 FUMARIC ACID ESTERS//DIMETHYL FUMARATE//DIMETHYLFUMARATE
5 0.0000058552 HEME OXYGENASE//HEME OXYGENASE 1//CARBON MONOXIDE
6 0.0000052307 URSOLIC ACID//OLEANOLIC ACID//MASLINIC ACID
7 0.0000048797 SESTRIN 2//TP53INP1//SESTRIN
8 0.0000041856 DENT PHARM 3126//CYP3A23//CYPLAL
9 0.0000041312 GLUTAMATE CYSTEINE LIGASE//GLUTATHIONE SYNTHETASE DEFICIENCY//GAMMA GLUTAMYLCYSTEINE SYNTHETASE
10 0.0000038160 MOVEMENT ACTIVITY//PIPERONYL BUTOXIDE//CYP1A INDUCER