Class information for:
Level 1: SQUALENE SYNTHASE//ZARAGOZIC ACIDS//SQUALENE SYNTHASE INHIBITOR

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
19557 435 32.7 73%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1073 9451 OXIDOSQUALENE CYCLASE//ISOPRENOID BIOSYNTHESIS//ORGANIC GEOCHEMISTRY

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 SQUALENE SYNTHASE Author keyword 27 41% 12% 51
2 ZARAGOZIC ACIDS Author keyword 27 83% 3% 15
3 SQUALENE SYNTHASE INHIBITOR Author keyword 25 75% 4% 18
4 SQUALESTATINS Author keyword 14 100% 2% 7
5 ZARAGOZIC ACID Author keyword 9 59% 2% 10
6 SQUALENE SYNTHASE INHIBITORS Author keyword 7 56% 2% 9
7 YM 53601 Author keyword 6 100% 1% 4
8 TAK 475 Author keyword 3 60% 1% 3
9 SQUALENE SYNTHETASE Author keyword 1 38% 1% 3
10 4 1 BENZOXAZEPINE 3 ACETIC ACID Author keyword 1 100% 0% 2

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 SQUALENE SYNTHASE 27 41% 12% 51 Search SQUALENE+SYNTHASE Search SQUALENE+SYNTHASE
2 ZARAGOZIC ACIDS 27 83% 3% 15 Search ZARAGOZIC+ACIDS Search ZARAGOZIC+ACIDS
3 SQUALENE SYNTHASE INHIBITOR 25 75% 4% 18 Search SQUALENE+SYNTHASE+INHIBITOR Search SQUALENE+SYNTHASE+INHIBITOR
4 SQUALESTATINS 14 100% 2% 7 Search SQUALESTATINS Search SQUALESTATINS
5 ZARAGOZIC ACID 9 59% 2% 10 Search ZARAGOZIC+ACID Search ZARAGOZIC+ACID
6 SQUALENE SYNTHASE INHIBITORS 7 56% 2% 9 Search SQUALENE+SYNTHASE+INHIBITORS Search SQUALENE+SYNTHASE+INHIBITORS
7 YM 53601 6 100% 1% 4 Search YM+53601 Search YM+53601
8 TAK 475 3 60% 1% 3 Search TAK+475 Search TAK+475
9 SQUALENE SYNTHETASE 1 38% 1% 3 Search SQUALENE+SYNTHETASE Search SQUALENE+SYNTHETASE
10 4 1 BENZOXAZEPINE 3 ACETIC ACID 1 100% 0% 2 Search 4+1+BENZOXAZEPINE+3+ACETIC+ACID Search 4+1+BENZOXAZEPINE+3+ACETIC+ACID

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 SQUALESTATINS 73 86% 9% 37
2 RELAY COMPOUND 55 92% 5% 22
3 A SQUALESTATIN S1 51 91% 5% 21
4 PHOMA 30 50% 10% 44
5 4 1 BENZOXAZEPINE DERIVATIVES 21 90% 2% 9
6 SQUALENE SYNTHASE 15 21% 15% 65
7 PRESQUALENE PYROPHOSPHATE 15 63% 3% 15
8 AMMONIUM ANALOGS 13 80% 2% 8
9 SQUALENE SYNTHASE INHIBITOR 13 40% 6% 25
10 BICYCLIC ACETAL CORE 12 86% 1% 6

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
(+)-ZARAGOZIC-ACID-C - SYNTHESIS AND RELATED STUDIES 1995 127 93 47%
Squalene Synthase Inhibitors: An Update on the Search for New Antihyperlipidemic and Antiatherosclerotic Agents 2011 10 127 62%
Squalene synthase inhibitors 1996 64 144 67%
SYNTHESIS OF ZARAGOZIC ACID A/SQUALESTATIN S1 1995 77 94 55%
Total syntheses of zaragozic acids A and C by a carbonyl ylide cycloaddition strategy 2006 26 128 58%
DISCOVERY, BIOSYNTHESIS, AND MECHANISM OF ACTION OF THE ZARAGOZIC ACIDS - POTENT INHIBITORS OF SQUALENE SYNTHASE 1995 87 43 49%
Total synthesis of zaragozic acid C by an aldol-based strategy 2005 15 97 71%
Recent progress in the synthesis of zaragozic acids and analogs 2001 19 101 61%
Pharmacologic Inhibition of Squalene Synthase and Other Downstream Enzymes of the Cholesterol Synthesis Pathway A New Therapeutic Approach to Treatment of Hypercholesterolemia 2009 21 41 37%
Total synthesis of the squalene synthase inhibitor zaragozic acid C 2005 14 62 60%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ.
in class
1 STIINTE INGINE TI 1 50% 0.2% 1
2 CHIM FILIERA ENGLEZA 0 33% 0.2% 1
3 UNITE MIXTE 7565 CNRS 0 33% 0.2% 1
4 MED CHEM WUPPERTAL 0 18% 0.5% 2
5 LEAD DISCOVERY OPTIMIZAT S 2 0 13% 0.7% 3
6 LEAD DISCOVERY OPTIMIZAT S 1 0 12% 0.7% 3
7 CORE IL HIGH THROUGHPUT PROT CRYSTALLOG 0 17% 0.5% 2
8 CARDIOVASC METAB S 0 10% 0.7% 3
9 CRYSTALLOG MODELISAT MAT MINERAUX BIOL 0 25% 0.2% 1
10 MED CHEM EUROPE 0 25% 0.2% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000135447 OXIDOSQUALENE CYCLASE//BETA AMYRIN SYNTHASE//TRITERPENE SYNTHASE
2 0.0000095102 STEROL METHYLTRANSFERASE//AZASTEROLS//STEROL C24 METHYLTRANSFERASE
3 0.0000094333 TERPENE SYNTHASE//PRENYLTRANSFERASE//MONOTERPENE SYNTHASE
4 0.0000080242 FOOD FUS COMPLEX//KARMELLAE//HYPOCHOLESTEROLEMIC PEPTIDE
5 0.0000080109 BOTRYOCOCCUS BRAUNII//BOTRYOCOCCENE//BOTRYOCOCCENES
6 0.0000076994 CHEM TECHNOL MEGURO KU//GYMNOTHECA CHINENSIS//WITTIG REARRANGEMENT
7 0.0000063446 MEFLOQUINE DERIVATIVES//QUINCORIDINE//QUINCORINE
8 0.0000062825 FARNESYLTRANSFERASE//FARNESYL TRANSFERASE INHIBITOR//FARNESYL TRANSFERASE INHIBITORS
9 0.0000058019 MACROLACTIN A//7 O SUCCINYL MACROLACTIN A//MACROLACTINS
10 0.0000051846 BONE TARGETING//OSTEOTROPIC DRUG DELIVERY SYSTEM//FARNESYL PYROPHOSPHATE SYNTHASE