Class information for:
Level 1: CB1954//ADEPT//ANTIBODY DIRECTED ENZYME PRODRUG THERAPY

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
15670 629 37.0 77%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1512 6953 ONCOLYTIC VIRUS//VIROTHERAPY//CYTOSINE DEAMINASE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CB1954 Author keyword 52 82% 5% 31
2 ADEPT Author keyword 43 47% 10% 66
3 ANTIBODY DIRECTED ENZYME PRODRUG THERAPY Author keyword 20 67% 3% 18
4 NITROREDUCTASE Author keyword 16 27% 8% 51
5 VDEPT Author keyword 10 58% 2% 11
6 HUMAN BETA GLUCURONIDASE Author keyword 8 100% 1% 5
7 GDEPT Author keyword 7 29% 3% 21
8 ANTIBODY ENZYME CONJUGATE Author keyword 6 71% 1% 5
9 ESCHERICHIA COLI NITROREDUCTASE Author keyword 6 71% 1% 5
10 NITROAROMATIC PRODRUG Author keyword 6 100% 1% 4

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 CB1954 52 82% 5% 31 Search CB1954 Search CB1954
2 ADEPT 43 47% 10% 66 Search ADEPT Search ADEPT
3 ANTIBODY DIRECTED ENZYME PRODRUG THERAPY 20 67% 3% 18 Search ANTIBODY+DIRECTED+ENZYME+PRODRUG+THERAPY Search ANTIBODY+DIRECTED+ENZYME+PRODRUG+THERAPY
4 NITROREDUCTASE 16 27% 8% 51 Search NITROREDUCTASE Search NITROREDUCTASE
5 VDEPT 10 58% 2% 11 Search VDEPT Search VDEPT
6 HUMAN BETA GLUCURONIDASE 8 100% 1% 5 Search HUMAN+BETA+GLUCURONIDASE Search HUMAN+BETA+GLUCURONIDASE
7 GDEPT 7 29% 3% 21 Search GDEPT Search GDEPT
8 ANTIBODY ENZYME CONJUGATE 6 71% 1% 5 Search ANTIBODY+ENZYME+CONJUGATE Search ANTIBODY+ENZYME+CONJUGATE
9 ESCHERICHIA COLI NITROREDUCTASE 6 71% 1% 5 Search ESCHERICHIA+COLI+NITROREDUCTASE Search ESCHERICHIA+COLI+NITROREDUCTASE
10 NITROAROMATIC PRODRUG 6 100% 1% 4 Search NITROAROMATIC+PRODRUG Search NITROAROMATIC+PRODRUG

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 5 AZIRIDIN 1 YL 2 4 DINITROBENZAMIDE CB1954 77 82% 7% 45
2 G AMIDASE CONJUGATE 57 95% 3% 19
3 CB 1954 44 71% 6% 36
4 THERAPY ADEPT 42 75% 5% 30
5 ADEPT 37 56% 7% 45
6 B NITROREDUCTASE 34 93% 2% 13
7 ESCHERICHIA COLI NITROREDUCTASE 31 42% 9% 57
8 INTERSTRAND CROSSLINKING AGENT 21 73% 3% 16
9 CB1954 19 71% 2% 15
10 5 AZIRIDIN 1 YL 2 4 DINITROBENZAMIDE CB 1954 18 57% 3% 21

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Targeting: The ADEPT Story So Far 2009 33 35 74%
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer 2006 51 84 64%
Beta-glucuronidase-mediated drug release 2002 65 63 71%
Selective activation of anticancer prodrugs by monoclonal antibody-enzyme conjugates 2001 87 90 78%
The choice of prodrugs for gene directed enzyme prodrug therapy of cancer 1995 115 55 71%
Antibody-enzyme conjugates for cancer therapy 1996 75 67 69%
Targeted Prodrug Approaches for Hormone Refractory Prostate Cancer 2015 2 164 14%
Antibody-directed enzyme prodrug therapy (ADEPT): A review 1997 65 95 87%
DESIGN OF ANTITUMOR PRODRUGS - SUBSTRATES FOR ANTIBODY-TARGETED ENZYMES 1994 86 35 97%
Antibody directed enzyme prodrug therapy (ADEPT): A review of the experimental and clinical considerations 1999 82 56 61%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 TY MYDDFAI 4 75% 0.5% 3
2 ADUBILTEM SCI TECHNOL DEV 3 100% 0.5% 3
3 NUCL PLICAT 3 14% 3.2% 20
4 COBRA THER EUT LTD 2 44% 0.6% 4
5 MED KLIN WERPUNKT HAMATOL ONKOL CBF 1 100% 0.3% 2
6 GRP SYST MOL PROGRAMMES 1 33% 0.3% 2
7 CIBLAGE IMAGERIE FONCT PROG S TUMORALE 1 50% 0.2% 1
8 CLIN VACCINOL TROP MED NDM 1 50% 0.2% 1
9 CR UK TARGETING IMAGING GRP 1 50% 0.2% 1
10 IMMUNREGULAT 1 50% 0.2% 1

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000158767 DUOCARMYCINS//CC 1065//DUOCARMYCIN
2 0.0000151040 CYTOSINE DEAMINASE//SUICIDE GENE THERAPY//HERPES SIMPLEX VIRUS THYMIDINE KINASE
3 0.0000136019 SELF IMMOLATIVE//POLYMETHYL GLYOXYLATE//BIOMED SCI PROGRAMS
4 0.0000130412 CORTISOL METABOLITE//GLUCRONIDE//PHAMACOL THER EUT
5 0.0000093380 ANTIBODY DRUG CONJUGATE//ANTIBODY DRUG CONJUGATES//T DM1
6 0.0000090671 BACTOFECTION//BACTERIAL THERAPY//SALMONELLA TYPHIMURIUM A1 R
7 0.0000085067 TIRAPAZAMINE//HYPOXIC CELL RADIOSENSITIZER//KU 2285
8 0.0000071736 HPMA COPOLYMERS//HPMA COPOLYMER//POLYMER THER EUT
9 0.0000068121 GRP PEPTIDE CHEM//BRANCHED POLYPEPTIDES//HUNGARIAN SCI PEPTIDE CHEM GRP
10 0.0000060466 PROXIMITY ORIENTATION//CYCLIC PRODRUG//ESTERASE SENSITIVE PRODRUGS