Class information for:
Level 1: TOFACITINIB//JAK3//CP 690 550

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
15305 650 46.0 90%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
1842 5623 STAT3//INTERLEUKIN 7//SOCS

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 TOFACITINIB Author keyword 30 54% 6% 38
2 JAK3 Author keyword 27 43% 8% 49
3 CP 690 550 Author keyword 15 82% 1% 9
4 JAK1 INHIBITOR Author keyword 11 100% 1% 6
5 WHI P131 Author keyword 9 83% 1% 5
6 JAK3 INHIBITOR Author keyword 8 70% 1% 7
7 550 Author keyword 8 100% 1% 5
8 JANUS KINASE Author keyword 8 20% 6% 36
9 JANUS KINASE 3 Author keyword 8 50% 2% 11
10 JANUS KINASE 3 JAK3 Author keyword 6 80% 1% 4

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 TOFACITINIB 30 54% 6% 38 Search TOFACITINIB Search TOFACITINIB
2 JAK3 27 43% 8% 49 Search JAK3 Search JAK3
3 CP 690 550 15 82% 1% 9 Search CP+690+550 Search CP+690+550
4 JAK1 INHIBITOR 11 100% 1% 6 Search JAK1+INHIBITOR Search JAK1+INHIBITOR
5 WHI P131 9 83% 1% 5 Search WHI+P131 Search WHI+P131
6 JAK3 INHIBITOR 8 70% 1% 7 Search JAK3+INHIBITOR Search JAK3+INHIBITOR
7 550 8 100% 1% 5 Search 550 Search 550
8 JANUS KINASE 8 20% 6% 36 Search JANUS+KINASE Search JANUS+KINASE
9 JANUS KINASE 3 8 50% 2% 11 Search JANUS+KINASE+3 Search JANUS+KINASE+3
10 JANUS KINASE 3 JAK3 6 80% 1% 4 Search JANUS+KINASE+3+JAK3 Search JANUS+KINASE+3+JAK3

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 CP 690 550 129 85% 10% 68
2 JAK INHIBITOR 48 72% 6% 38
3 CP 690550 42 94% 2% 15
4 MICE LACKING JAK3 36 36% 12% 81
5 JANUS KINASE 3 34 65% 5% 32
6 TOFACITINIB CP 690 550 31 74% 4% 23
7 JAK3 19 47% 5% 30
8 JANUS KINASE INHIBITOR 18 45% 4% 29
9 JANUS KINASES 17 32% 7% 46
10 TYK2 DEFICIENT MICE 13 62% 2% 13

Journals

Reviews


Title Publ. year Cit. Active references % act. ref.
to same field
Janus kinases in immune cell signaling 2009 244 137 42%
Treating inflammation with the Janus Kinase inhibitor CP-690,550 2011 38 56 64%
New Drugs and Treatment Targets in Psoriasis 2015 5 30 17%
JAK Inhibitors: Treatment Efficacy and Safety Profile in Patients with Psoriasis 2014 7 40 53%
The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention 2015 2 75 35%
The Janus kinases (Jaks) 2004 188 55 42%
Therapeutic targeting of Janus kinases 2008 105 93 34%
Systematic Review of Tofacitinib: A New Drug for the Management of Rheumatoid Arthritis 2014 6 18 50%
JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical 2013 10 33 79%
Therapeutic Targeting of the JAK/STAT Pathway 2014 6 39 46%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 MOL IMMUNOL INFLAMMAT BRANCH 6 18% 4.8% 31
2 EXPT BMT PROGRAM 4 75% 0.5% 3
3 TRANSLAT IMMUNOL SECT 3 57% 0.6% 4
4 ANTIBACTERIALS IMMUNOL 3 100% 0.5% 3
5 PARKER HUGHES CANC 3 24% 1.8% 12
6 CARDIOTHORAC SURGTRANSPLANTAT IMMUNOL 3 60% 0.5% 3
7 ANTIBACTERIALS INFLAMMAT IMMUNOL 2 67% 0.3% 2
8 SIGNALISAT CYTOKINES 2 67% 0.3% 2
9 ANTIBACTERIALS IMMUNOL CANC 2 43% 0.5% 3
10 CARDIOTHORAC SURGFALK CARDIOVASC 1 50% 0.3% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000153879 STAT3//STAT5//STAT
2 0.0000119593 OMENN SYNDROME//SEVERE COMBINED IMMUNODEFICIENCY//T CELL LYMPHOPENIA
3 0.0000105640 INTERLEUKIN 7//IL 7//INTERLEUKIN 7 RECEPTOR
4 0.0000089552 ESSENTIAL THROMBOCYTHEMIA//POLYCYTHEMIA VERA//MYELOFIBROSIS
5 0.0000087282 INTERFERON RECEPTOR//IFNAR2//IFNAR1
6 0.0000085739 SYK//SPLEEN TYROSINE KINASE//R788
7 0.0000085588 SOCS//SOCS1//SOCS3
8 0.0000061060 CARDIOTROPHIN 1//CARDIOTROPHIN//ERK 1 AND 2
9 0.0000056397 MOL TUMOR BIOL//CELLULAR GENE THER IES//IL 13 RECEPTOR
10 0.0000054178 X LINKED AGAMMAGLOBULINEMIA//BRUTONS TYROSINE KINASE//BTK