Class information for:
Level 1: LEFLUNOMIDE//DIHYDROOROTATE DEHYDROGENASE//DG RHEUMATOL

Basic class information
ID Publications Average number
of references		 Avg. shr. active
ref. in WoS
10430 998 28.7 77%


Bar chart of Publication_year

Last years might be incomplete

Classes in level above (level 2)


ID, lev.
above		 Publications Label for level above
3042 1966 LEFLUNOMIDE//LINOMIDE//MIZORIBINE

Terms with highest relevance score


Rank Term Type of term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 LEFLUNOMIDE Author keyword 175 50% 25% 249
2 DIHYDROOROTATE DEHYDROGENASE Author keyword 87 76% 6% 62
3 DG RHEUMATOL Address 36 83% 2% 20
4 DG RHEUMATOL IMMUNOL Address 24 91% 1% 10
5 BREQUINAR Author keyword 23 76% 2% 16
6 A771726 Author keyword 18 89% 1% 8
7 DIHYDROOROTATE DEHYDROGENASE DHODH Author keyword 18 89% 1% 8
8 FK778 Author keyword 17 72% 1% 13
9 A77 1726 Author keyword 15 71% 1% 12
10 TERIFLUNOMIDE Author keyword 12 37% 3% 26

Web of Science journal categories

Author Key Words


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class		 LCSH search Wikipedia search
1 LEFLUNOMIDE 175 50% 25% 249 Search LEFLUNOMIDE Search LEFLUNOMIDE
2 DIHYDROOROTATE DEHYDROGENASE 87 76% 6% 62 Search DIHYDROOROTATE+DEHYDROGENASE Search DIHYDROOROTATE+DEHYDROGENASE
3 BREQUINAR 23 76% 2% 16 Search BREQUINAR Search BREQUINAR
4 A771726 18 89% 1% 8 Search A771726 Search A771726
5 DIHYDROOROTATE DEHYDROGENASE DHODH 18 89% 1% 8 Search DIHYDROOROTATE+DEHYDROGENASE+DHODH Search DIHYDROOROTATE+DEHYDROGENASE+DHODH
6 FK778 17 72% 1% 13 Search FK778 Search FK778
7 A77 1726 15 71% 1% 12 Search A77+1726 Search A77+1726
8 TERIFLUNOMIDE 12 37% 3% 26 Search TERIFLUNOMIDE Search TERIFLUNOMIDE
9 BREQUINAR SODIUM 11 78% 1% 7 Search BREQUINAR+SODIUM Search BREQUINAR+SODIUM
10 HDHODH INHIBITORS 8 100% 1% 5 Search HDHODH+INHIBITORS Search HDHODH+INHIBITORS

Key Words Plus


Rank Web of Science journal category Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 A77 1726 116 88% 6% 56
2 HWA 486 79 85% 4% 41
3 LEFLUNOMIDE 73 35% 17% 170
4 NSC 368390 53 95% 2% 18
5 DIHYDROOROTATE DEHYDROGENASE 49 41% 9% 93
6 BREQUINAR SODIUM 45 64% 4% 44
7 IMMUNOSUPPRESSIVE METABOLITE 44 85% 2% 23
8 IMMUNOSUPPRESSIVE AGENT LEFLUNOMIDE 31 53% 4% 41
9 DHODH INHIBITORS 26 87% 1% 13
10 HUMAN DIHYDROOROTATE DEHYDROGENASE 26 68% 2% 23

Journals

Reviews


Title Publ. year Cit. Active
references		 % act. ref.
to same field
Immune mechanisms of new therapeutic strategies in MS - Teriflunomide 2012 33 49 80%
Clinical pharmacokinetics of leflunomide 2002 94 9 100%
Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors 2011 20 57 93%
Benefit-Risk Assessment of Leflunomide An Appraisal of Leflunomide in Rheumatoid Arthritis 10 Years After Licensing 2009 52 55 71%
Leflunomide in the treatment of rheumatoid arthritis 2004 45 43 91%
Leflunomide: mode of action in the treatment of rheumatoid arthritis 2000 165 67 73%
An update of teriflunomide for treatment of multiple sclerosis 2013 6 40 73%
Stimulation of the antiviral innate immune response by pyrimidine biosynthesis inhibitors: a surprise of phenotypic screening 2015 1 24 25%
Safety evaluation of leflunomide in rheumatoid arthritis 2013 4 42 74%
Leflunomide for the treatment of rheumatoid arthritis: A systematic review and metaanalysis 2003 58 26 62%

Address terms


Rank Address term Relevance score
(tfidf)		 Class's shr.
of term's tot.
occurrences		 Shr. of publ.
in class containing
term		 Num. of
publ. in
class
1 DG RHEUMATOL 36 83% 2.0% 20
2 DG RHEUMATOL IMMUNOL 24 91% 1.0% 10
3 BEHRINGWERKE AG 8 100% 0.5% 5
4 IMMUNOL DOMAIN 6 100% 0.4% 4
5 CHEM GLOBAL HLTH 4 67% 0.4% 4
6 CRISTALOG PROT 4 41% 0.7% 7
7 PHARMA WERK KALLE ALBERT 3 100% 0.3% 3
8 SUB PHARMACOTHER Y PHARMACEUT CARE 3 60% 0.3% 3
9 HGRP PHARM 2 67% 0.2% 2
10 WERK KALLE ALBERT 2 67% 0.2% 2

Related classes at same level (level 1)


Rank Relatedness score Related classes
1 0.0000093788 RHEUMATOLOTA KU//MDR I//DANINI HOSP
2 0.0000064527 METHOTREXATE//METHOTREXATE POLYGLUTAMATES//MX 68
3 0.0000063822 ABATACEPT//TOCILIZUMAB//DISEASE MODIFYING ANTIRHEUMATIC DRUGS
4 0.0000060523 LINOMIDE//ROQUINIMEX//LAQUINIMOD
5 0.0000059465 MIZORIBINE//COMPARAT TRANSPLANTAT//ORAL MIZORIBINE PULSE THERAPY
6 0.0000058374 DEOXYSPERGUALIN//15 DEOXYSPERGUALIN//AXE IMMUNOL
7 0.0000056551 AG LES MARKUS KRANKENHAUS//DESERT ORTHOPED//DISEASE MODIFYING ANTI RHEUMATIC DRUGS DMARD
8 0.0000054960 APICOPLAST//41H QUINOLONES//ORGANELLAR TARGETING
9 0.0000045403 CARAB//PYRIMIDINE REGULATION//PYRR
10 0.0000044080 DIHYDROOROTASE//CARBAMOYL PHOSPHATE SYNTHETASE//ASPARTATE CARBAMOYLTRANSFERASE